4.7 Article

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta- Lactamase Inhibitors: Initial Leads toward Clinical Candidates

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Christopher J. L. Murray et al.

Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.

LANCET (2022)

Article Chemistry, Multidisciplinary

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Jurgen Brem et al.

Summary: The discovery of a potent new class of MBL inhibitor, InCs, restores carbapenem activity against multidrug-resistant bacteria with low resistance frequency. In combination with meropenem, InCs show strong in vivo efficacy in mouse infection models.

NATURE CHEMISTRY (2022)

Article Chemistry, Medicinal

Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates

Alistair J. M. Farley et al.

Summary: N-sulfamoylpyrrole-2-carboxylates (NSPCs) show promise as efficient MBL inhibitors, restoring antibiotic efficacy in clinically relevant bacteria. Further optimization is needed for clinical development, but the results are encouraging.

ACS INFECTIOUS DISEASES (2021)

Article Chemistry, Medicinal

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

Scott J. Hecker et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Targeting Metalloenzymes for Therapeutic Intervention

Allie Y. Chen et al.

CHEMICAL REVIEWS (2019)

Review Microbiology

Interplay between β-lactamases and new β-lactamase inhibitors

Karen Bush et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Chemistry, Physical

Quantum chemical pKa prediction for complex organic molecules

Dean M. Philipp et al.

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY (2018)

Article Chemistry, Medicinal

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-beta-Lactamases

Dominik Buettner et al.

ACS INFECTIOUS DISEASES (2018)

Article Microbiology

Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1

Hongmin Zhang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2018)

Article Multidisciplinary Sciences

Predictive compound accumulation rules yield a broad - spectrum antibiotic

Michelle F. Richter et al.

NATURE (2017)

Article Chemistry, Medicinal

Interactive and Versatile Navigation of Structural Databases

Oliver Korb et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Philip Hinchliffe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Infectious Diseases

From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials

Dubravko Jelic et al.

ANTIBIOTICS-BASEL (2016)

Article Chemistry, Medicinal

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

Mariano M. Gonzalez et al.

ACS INFECTIOUS DISEASES (2015)

Review Microbiology

Molecular mechanisms of antibiotic resistance

Jessica M. A. Blair et al.

NATURE REVIEWS MICROBIOLOGY (2015)

Article Chemistry, Medicinal

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

Timothy A. Blizzard et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Chemistry, Multidisciplinary

Neutron Diffraction of Acetazolamide-Bound Human Carbonic Anhydrase II Reveals Atomic Details of Drug Binding

S. Zoe Fisher et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor

David E. Ehmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Microbiology

Biochemical and Structural Characterization of the Subclass B1 Metallo-β-Lactamase VIM-4

Patricia Lassaux et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Chemistry, Medicinal

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

Helen Chen et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Review Microbiology

Updated Functional Classification of beta-Lactamases

Karen Bush et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Article Chemistry, Medicinal

NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase

Timo Weide et al.

ACS MEDICINAL CHEMISTRY LETTERS (2010)

Review Biotechnology & Applied Microbiology

Clavulanic acid: A review

Parag S. Saudagar et al.

BIOTECHNOLOGY ADVANCES (2008)

Article Chemistry, Medicinal

Physicochemical properties of antibacterial compounds: Implications for drug discovery

Rosemarie O'Shea et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Chemistry, Organic

Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols

Benoit M. R. Lienard et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2008)

Article Multidisciplinary Sciences

A chemical method for fast and sensitive detection of DNA synthesis in vivo

Adrian Salic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

Resistance to β-lactam antibiotics

K Poole

CELLULAR AND MOLECULAR LIFE SCIENCES (2004)

Article Biochemistry & Molecular Biology

Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase

JH Toney et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)