相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B
Yuichi Wakabayashi et al.
JOURNAL OF NUCLEAR MEDICINE (2022)
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors
Chiara Brullo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Challenges on Cyclic Nucleotide Phosphodiesterases Imaging with Positron Emission Tomography: Novel Radioligands and (Pre-)Clinical Insights since 2016
Susann Schroder et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery
Jiyun Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D
Yuichi Wakabayashi et al.
ACS CHEMICAL NEUROSCIENCE (2020)
Automated, Accurate, and Scalable Relative Protein-Ligand Binding Free-Energy Calculations Using Lambda Dynamics
E. Prabhu Raman et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2020)
Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N-, and 15O-Labeling Reactions
Xiaoyun Deng et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
Mark E. Gurney et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Human Positron Emission Tomography Neuroimaging
Jacob M. Hooker et al.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 21 (2019)
Overcoming Challenging Substituent Perturbations with Multisite λ-Dynamics: A Case Study Targeting β-Secretase 1
Jonah Z. Vilseck et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2019)
Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
Masakazu NamboD et al.
NATURE COMMUNICATIONS (2019)
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Vaclav Nemec et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Predicting Binding Free Energies in a Large Combinatorial Chemical Space Using Multisite λ Dynamics
Jonah Z. Vilseck et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2018)
Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
Chong Zhang et al.
NEUROPSYCHOPHARMACOLOGY (2018)
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Lei Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Loss of phosphodiesterase 4 in Parkinson disease Relevance to cognitive deficits
Flavia Niccolini et al.
NEUROLOGY (2017)
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling
Natura Myeku et al.
NATURE MEDICINE (2016)
Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging
Victor W. Pike
CURRENT MEDICINAL CHEMISTRY (2016)
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics
Pasqualina D'Ursi et al.
MOLECULAR INFORMATICS (2016)
Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
Susann Schroeder et al.
MOLECULES (2016)
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors
Chiara Brullo et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Apremilast: A Review in Psoriasis and Psoriatic Arthritis
Emma D. Deeks
DRUGS (2015)
Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4
Peder Cedervall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Discovery of triazines as selective PDE4B versus PDE4D inhibitors
Timothy J. Hagen et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Structural basis for the design of selective phosphodiesterase 4B inhibitors
David Fox et al.
CELLULAR SIGNALLING (2014)
Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand
Lei Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Downregulation of Brain Phosphodiesterase Type IV Measured with 11C-(R)-Rolipram Positron Emission Tomography in Major Depressive Disorder
Masahiro Fujita et al.
BIOLOGICAL PSYCHIATRY (2012)
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Sharron H. Francis et al.
PHYSIOLOGICAL REVIEWS (2011)
Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
Travis T. Wager et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
Travis T. Wager et al.
ACS CHEMICAL NEUROSCIENCE (2010)
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors
Renee Aspiotis et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
Alex B. Burgin et al.
NATURE BIOTECHNOLOGY (2010)
How to improve R&D productivity: the pharmaceutical industry's grand challenge
Steven M. Paul et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Discovery of selective PDE4B inhibitors
Kenji Naganuma et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration
Michael D. Woodrow et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Reversal of long-term dendritic spine alterations in Alzheimer disease models
Donna L. Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
PDE4 inhibitors: current status
D. Spina
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for β-amyloid imaging in Alzheimer's disease with PET
C Solbach et al.
APPLIED RADIATION AND ISOTOPES (2005)
Structural basis for the activity of drugs that inhibit phosphodiesterases
GL Card et al.
STRUCTURE (2004)
Imaging cAMP-specific phosphodiesterase-4 in human brain with R-[11C]rolipram and positron emission tomography
JN DaSilva et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2002)
Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation:: Reversibility by drugs that enhance cAMP signaling
OV Vitolo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)