相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。PHYSIOLOGICAL ROLES OF MAMMALIAN TRANSMEMBRANE ADENYLYL CYCLASE ISOFORMS
Katrina F. Ostrom et al.
PHYSIOLOGICAL REVIEWS (2022)
Evolution of the drug-target residence time model
Robert A. Copeland
EXPERT OPINION ON DRUG DISCOVERY (2021)
Soluble adenylyl cyclase inhibition prevents human sperm function essential for fertilization
Melanie Balbach et al.
MOLECULAR HUMAN REPRODUCTION (2021)
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)
Makoto Fushimi et al.
ACS MEDICINAL CHEMISTRY LETTERS (2021)
Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase
Tom Rossetti et al.
INTERFACE FOCUS (2021)
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration
Melanie Balbach et al.
BIOLOGY OF REPRODUCTION (2020)
Metabolic and Pharmaceutical Aspects of Fluorinated Compounds
Benjamin M. Johnson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time
Avinash Khanna et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
A special issue on contraceptive development: past, present, and future
Martin M. Matzuk et al.
BIOLOGY OF REPRODUCTION (2020)
ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria
Arvand Akbari et al.
HUMAN REPRODUCTION (2019)
Computational Fluorine Scanning Using Free-Energy Perturbation
Alexander D. Wade et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application
Yoshihiko Hirozane et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Dorothee Liebschner et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)
Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways
Kin Sing Stephen Lee et al.
ACS CENTRAL SCIENCE (2019)
Shedding light on the role of cAMP in mammalian sperm physiology
Melanie Balbach et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)
Pharmacological modulation of the CO2/HCO3-/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase
Shakarr V. Wiggins et al.
PHARMACOLOGY & THERAPEUTICS (2018)
Drug metabolism in drug discovery and development
Zhoupeng Zhang et al.
ACTA PHARMACEUTICA SINICA B (2018)
Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH
Dalee Zhou et al.
SCIENCE SIGNALING (2018)
Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors
Jarel K. Gandhi et al.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2017)
High-Throughput Quantitative Intrinsic Thiol Reactivity Evaluation Using a Fluorescence-Based Competitive Endpoint Assay
Tomoya Sameshima et al.
SLAS DISCOVERY (2017)
Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools
Naiem T. Issa et al.
CURRENT DRUG METABOLISM (2017)
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
Doris A. Schuetz et al.
DRUG DISCOVERY TODAY (2017)
Soluble adenylyl cyclase is essential for proper lysosomal acidification
Nawreen Rahman et al.
JOURNAL OF GENERAL PHYSIOLOGY (2016)
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
Lavoisier Ramos-Espiritu et al.
NATURE CHEMICAL BIOLOGY (2016)
XDSAPP2.0
Karine M. Sparta et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2016)
Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field
Lingle Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Translating slow-binding inhibition kinetics into cellular and in vivo effects
Grant K. Walkup et al.
NATURE CHEMICAL BIOLOGY (2015)
Prolonged and tunable residence time using reversible covalent kinase inhibitors
J. Michael Bradshaw et al.
NATURE CHEMICAL BIOLOGY (2015)
Structure, mechanism, and regulation of soluble adenylyl cyclases - similarities and differences to transmembrane adenylyl cyclases
Clemens Steegborn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Central role of soluble adenylyl cyclase and cAMP in sperm physiology
Mariano G. Buffone et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Role of soluble adenylyl cyclase in mitochondria
Federica Valsecchi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
The role of soluble adenylyl cyclase in health and disease Preface
Jochen Buck et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
Silke Kleinboelting et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase
Silke Kleinboelting et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2014)
Impact of Physicochemical Profiling for Rational Approach on Drug Discovery
Shoko Nakashima et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2013)
CO2/HCO3-- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor
Jonathan H. Zippin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin
Uwe Mueller et al.
JOURNAL OF SYNCHROTRON RADIATION (2012)
Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis
Robert A. Copeland et al.
ANALYTICAL BIOCHEMISTRY (2011)
Regulation of Anterior Chamber Drainage by Bicarbonate-sensitive Soluble Adenylyl Cyclase in the Ciliary Body
Yong S. Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Molecular details of cAMP generation in mammalian cells: A tale of two systems
Margarita Kamenetsky et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization
Fang Xie et al.
DEVELOPMENTAL BIOLOGY (2006)
The Soluble adenylyl cyclase in sperm mediates multiple signaling events required for fertilization
KC Hess et al.
DEVELOPMENTAL CELL (2005)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect
G Esposito et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Bicarbonate-responsive soluble adenylyl cyclase defines a nuclear cAMP microdomain
JH Zippin et al.
JOURNAL OF CELL BIOLOGY (2004)
Kinetic properties of soluble adenylyl cyclase - Synergism between calcium and bicarbonate
TN Litvin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bicarbonate actions on flagellar and Ca2+-channel responses:: initial events in sperm activation
G Wennemuth et al.
DEVELOPMENT (2003)
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
YQ Chen et al.
SCIENCE (2000)