4.7 Article

Clinical features, therapeutic outcomes, and recovery period of long COVID

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Epidemiological and clinical risk factors related to severe COVID-19 in Iran: a multi-center study

Seyed Mohammad Hashemi-Shahri et al.

Summary: This study investigated the epidemiological and clinical features of COVID-19 in a less privileged area in Iran and found that older age, a history of substance abuse, and underlying diseases were associated with increased severity of the disease.

BMC INFECTIOUS DISEASES (2022)

Article Infectious Diseases

Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea

Yoonjung Kim et al.

Summary: As the COVID-19 pandemic continues, understanding its long-term impacts is becoming more important. This study conducted two surveys on recovered patients to evaluate the long-term course of symptoms and quality of life. The results showed that COVID-19-related persistent symptoms improved over time, but neurological symptoms can last longer. Age, sex, and disease severity were identified as risk factors for persistent neuropsychiatric symptoms.

BMC INFECTIOUS DISEASES (2022)

Review Infectious Diseases

Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review

Nhu Ngoc Nguyen et al.

Summary: This study aims to describe the burden of long-term persistence of clinical symptoms in COVID-19 patients through a systematic review. The most frequent persisting symptoms include fatigue, dyspnea, cough, arthralgia, and thoracic pain. Female gender, older age, comorbidities, and severity at the acute phase were identified as the main risk factors for persisting symptoms.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2022)

Article Infectious Diseases

Determinants of persistence of symptoms and impact on physical and mental wellbeing in Long COVID: A prospective cohort study

Elda Righi et al.

Summary: Residual symptoms can persist for several months after COVID-19, affecting both physical and mental wellbeing. Age, hospitalization, and symptom duration are predictors of symptom persistence. This study helps identify target populations and plan long-term recovery interventions.

JOURNAL OF INFECTION (2022)

Article Medicine, General & Internal

Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study

Cesar Fernandez-de-las-Penas et al.

Summary: This study investigated the differences in COVID-19 related symptoms and post-COVID symptoms between male and female COVID-19 survivors. It found that post-COVID symptoms were present in up to 60% of hospitalized COVID-19 survivors eight months after the infection, with female survivors experiencing more symptoms than males. Female sex was also associated with a higher risk of developing mood disorders and other long-term post-COVID symptoms.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Infectious Diseases

Symptoms Experienced at the Acute Phase of SARS-CoV-2 Infection as Risk Factor of Long-term Post-COVID Symptoms: The LONG-COVID-EXP-CM Multicenter Study

Cesar Fernandez-de-las-Penas et al.

Summary: This multicenter study found that female gender, number of morbidities, number of symptoms at hospital admission, and days at the hospital were associated with a higher number of long-term symptoms after COVID. Symptoms such as vomiting, throat pain, diarrhea, dyspnea, or headache at hospital admission were also associated with more symptoms after COVID.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Article Virology

Relationship between changes in symptoms and antibody titers after a single vaccination in patients with Long COVID

Tomoya Tsuchida et al.

Summary: This study evaluated the changes in symptoms and antibody titers in patients with Long COVID after vaccination. Some patients experienced symptom relief, while others experienced worsening. The worsened group had a higher increase in antibody titers, indicating a possible link between excessive immune response and worsening of sequelae.

JOURNAL OF MEDICAL VIROLOGY (2022)

Article Multidisciplinary Sciences

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Gwenaelle Douaud et al.

Summary: Through long-term observation of participants' MRI images, it was found that COVID-19 infection is associated with abnormal brain changes, including a reduction in gray matter thickness in the orbitofrontal cortex and parahippocampal gyrus, greater changes in markers of tissue damage in regions functionally connected to the primary olfactory cortex, and a greater reduction in global brain size. Infected individuals also showed significant cognitive decline.

NATURE (2022)

Article Biochemistry & Molecular Biology

Long COVID after breakthrough SARS-CoV-2 infection

Ziyad Al-Aly et al.

Summary: This study analyzed the US Department of Veterans Affairs national healthcare databases to investigate the occurrence of Long COVID and death risk after breakthrough SARS-CoV-2 infection. The findings showed that vaccination significantly reduced the risk of death and post-acute sequelae but did not eliminate them completely. These results underscore the importance of further research on prevention and post-acute care for breakthrough infections.

NATURE MEDICINE (2022)

Article Geriatrics & Gerontology

Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

M. T. H. M. Henkens et al.

Summary: Age is the main determinant of COVID-19 related in-hospital mortality, with negligible mediation effect of pre-existing comorbidities.

BMC GERIATRICS (2022)

Article Biochemistry & Molecular Biology

Symptoms and risk factors for long COVID in non-hospitalized adults

Anuradhaa Subramanian et al.

Summary: A retrospective analysis of primary care records in the United Kingdom reveals individual symptoms associated with SARS-CoV-2 infections, which persisted for 12 weeks or more after infection, as well as risk factors associated with developing long COVID.

NATURE MEDICINE (2022)

Review Virology

The effect of smoking on COVID-19 severity: A systematic review and meta-analysis

Rohin K. Reddy et al.

Summary: Smoking is associated with increased risk of severe COVID-19 and worse in-hospital outcomes, as current smokers and patients with a smoking history are more susceptible to severe disease and have higher mortality rates.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

Editorial Material Medicine, General & Internal

Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline

Waqaar Shah et al.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Multidisciplinary Sciences

Prevalence and predictors of Post-Acute COVID-19 Syndrome (PACS) after hospital discharge: A cohort study with 4 months median follow-up

Imad M. Tleyjeh et al.

Summary: The study evaluated COVID-19 survivors post discharge and found that dyspnea, cough, and fatigue were common symptoms at 4 months after discharge. Risk factors for new or persistent symptoms included female gender, pre-existing hypertension, and longer hospital stays. Age, pre-existing lung disease, and emergency room visits were associated with not fully recovering from acute COVID-19. Patients treated with interferon beta-1b based triple antiviral therapy during hospital stay were less likely to have ongoing symptoms and more likely to return to baseline health.

PLOS ONE (2021)

Article Biochemistry & Molecular Biology

Attributes and predictors of long COVID

Carole H. Sudre et al.

Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

Risk factors and incidence of long-COVID syndrome in hospitalized patients: does remdesivir have a protective effect?

L. Boglione et al.

Summary: The study identified ICU admission, length of hospitalization, and treatment with remdesivir as independent predictors of LCS, with remdesivir treatment leading to a 35.9% reduction in LCS rate. Factors associated with the persistence of PCS at 6 months of follow-up include disease severity, need for ICU admission, and length of hospital stay.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

Article Infectious Diseases

Persistent COVID-19 symptoms are highly prevalent 6 months after hospitalization: results from a large prospective cohort

Jade Ghosn et al.

Summary: One fourth of individuals hospitalized for COVID-19 still experienced three or more persistent symptoms at six months after admission. Factors independently associated with the presence of three or more symptoms at month 6 included female gender, having three or more symptoms at admission, and ICU admission/transfer during the acute phase. Further longitudinal follow-up of severe COVID-19 patients is needed for better understanding of the long-term persistence of symptoms.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Pharmacology & Pharmacy

Immunological and Preventive Effects of Hochuekkito and Kakkonto Against Coronavirus Disease in Healthcare Workers: A Retrospective Observational Study

Keiko Ogawa-Ochiai et al.

Summary: The study retrospectively investigated the immunological and preventive effects of the traditional Chinese medicine compounds HET and KKT against COVID-19, demonstrating their potential in enhancing NK activity in circulating human immune cells and improving infectious immunosurveillance.

FRONTIERS IN PHARMACOLOGY (2021)

Article Medicine, General & Internal

Characterizing Long COVID: Deep Phenotype of a Complex Condition

Rachel R. Deer et al.

EBIOMEDICINE (2021)

Article Respiratory System

Prevalence of Post-COVID-19 Cough One Year After SARS-CoV-2 Infection: A Multicenter Study

Cesar Fernandez-de-las-Penas et al.

Summary: This study investigated the prevalence of post-COVID-19 cough one year after hospital discharge in COVID-19 survivors and found that a significant proportion of patients still experienced respiratory symptoms post-discharge, with a 2.5% prevalence of long-term cough. No clear risk factors associated with long-term post-COVID-19 cough were identified.
Article Medicine, General & Internal

A combination of herbal formulas, acupuncture, and novel pine-needle stimulation for recurrent alopecia areata A case report

Nozomu Kawashima et al.

Summary: The combination of traditional therapies such as Japanese Kampo medicine formulas, acupuncture, and self-administered pine-needle stimulation has been found to be an effective integrative treatment for patients with alopecia areata. This multimodal approach can help patients achieve significant recovery from hair loss.

MEDICINE (2021)

Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

Incidence and risk factors of long COVID in the UK: a single-centre observational study

Arvind Nune et al.

Summary: Long COVID is common in discharged patients and can last up to 9 months. Fatigue and breathlessness are the most common symptoms experienced.

JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF EDINBURGH (2021)

Article Critical Care Medicine

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

Sanjay Ramakrishnan et al.

Summary: The study found that early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and accelerated recovery time in patients with early COVID-19.

LANCET RESPIRATORY MEDICINE (2021)

Article Critical Care Medicine

3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study

Xiaojun Wu et al.

Summary: Most patients recovering from severe COVID-19 showed improvement in dyspnoea scores and exercise capacity over time, but a subgroup of patients still exhibited persistent physiological and radiographic changes at 12 months post-discharge. A unified pathway for respiratory follow-up is needed for COVID-19 patients.

LANCET RESPIRATORY MEDICINE (2021)

Article Medicine, General & Internal

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study

Lixue Huang et al.

LANCET (2021)

Review Substance Abuse

Smoking Is Independently Associated With an Increased Risk for COVID-19 Mortality: A Systematic Review and Meta-analysis Based on Adjusted Effect Estimates

Hongjie Hou et al.

Summary: A quantitative meta-analysis revealed a significant association between smoking and mortality of COVID-19 patients, with smoking increasing the risk of death. The study concluded that smoking independently contributes to an increased risk of mortality in COVID-19 patients, with stable and reliable results from sensitivity analysis.

NICOTINE & TOBACCO RESEARCH (2021)

Article Otorhinolaryngology

Recovery Over Time and Prognostic Factors in Treated Patients with Post-Infectious Olfactory Dysfunction: A Retrospective Study

Takao Ogawa et al.

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY (2020)

Editorial Material Public, Environmental & Occupational Health

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020

Mark W. Tenforde et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Letter Medicine, General & Internal

Persistent Symptoms in Patients After Acute COVID-19

Angelo Carfi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Editorial Material Medicine, General & Internal

Management of post-acute covid-19 in primary care

Trisha Greenhalgh et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Immunology

Prolonged and Late-Onset Symptoms of Coronavirus Disease 2019

Yusuke Miyazato et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

Editorial Material Medicine, General & Internal

A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection Illness Beyond Acute Infection and Public Health Implications

S. Deblina Datta et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Gastroenterology & Hepatology

Importance of fatigue and its measurement in chronic liver disease

Lynn H. Gerber et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Review Gastroenterology & Hepatology

Review article: treatment options for functional dyspepsia

Imke Masuy et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

Article Gastroenterology & Hepatology

Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease

W. Ray Kim et al.

HEPATOLOGY (2008)