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Article
Immunology
Sean P. Harrigan et al.
Summary: This study compared the severity of Omicron and Delta variants and found that Omicron-infected individuals had a lower risk of hospitalization and ICU admission compared to Delta-infected individuals. Additionally, the hospital stay was shorter for Omicron cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Raquel Viana et al.
Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Editorial Material
Infectious Diseases
Jannik Fonager et al.
Article
Multidisciplinary Sciences
Hiam Chemaitelly et al.
Summary: mRNA COVID-19 vaccines provide moderate and short-lived protection against symptomatic Omicron BA.1 and BA.2 infections, but strong and durable protection against COVID-19 hospitalization and death.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Aekkachai Tuekprakhon et al.
Summary: The Omicron variant of SARS-CoV-2 has rapidly spread globally and has evolved into different sublineages, with BA.4 and BA.5 dominating in South Africa. These sublineages show reduced neutralization by vaccine and naturally immune serum, indicating the possibility of repeat Omicron infections.
Article
Biochemistry & Molecular Biology
Houriiyah Tegally et al.
Summary: The genomic characterization of the SARS-CoV-2 Omicron lineages BA.4 and BA.5, responsible for the fifth wave of the COVID-19 pandemic in South Africa, reveals their continued viral diversification and sheds light on the potential mechanisms that allow these new lineages to outcompete their predecessors. These new lineages, BA.4 and BA.5, share identical spike proteins with BA.2 but have certain differences such as the presence of the 69-70 deletion, L452R, F486V, and the wild-type amino acid at Q493. They can be identified by the S-gene target failure, a proxy marker associated with the 69-70 deletion. BA.4 and BA.5 have rapidly replaced BA.2 and have become the dominant lineages in South Africa.
Article
Multidisciplinary Sciences
H. H. Webster et al.
Summary: In a large cohort study in England, it was found that COVID-19 cases with the Omicron sub-lineage BA.2 had lower or similar risks of death, hospital admission, and any hospital attendance compared to the BA.1 sub-lineage.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nicole Wolter et al.
Summary: Omicron lineages BA.4 and BA.5 drove a fifth wave of COVID-19 cases in South Africa. The severity of BA.4/BA.5 infections was similar to BA.1 infections and lower than the Delta variant.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Alain-Claude Kouamen et al.
Summary: The characteristics and clinical symptoms of individuals infected with BA.4 or BA.5 in France were found to be different from other variants, but overall, no severe clinical presentations were reported. The presence of risk factors significantly increased the risk of hospitalization among those infected with BA.4 or BA.5.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Computer Science, Information Systems
Sharon Relova et al.
Summary: Area-based socio-economic indicators, such as the Canadian Index of Multiple Deprivation (CIMD), play a significant role in improving patient care and public health services. The British Columbia Index of Multiple Deprivation (BCIMD) is developed based on the CIMD methodology to provide indexes at the Community Health Services Area (CHSA) level in British Columbia. This data is used for monitoring population demographics and informing healthcare decision making.
