期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 36, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2023.2167075
关键词
Antenatal identification; fetal growth restriction; intrauterine fetal death; stillbirth; population-based study
This retrospective study reviewed all stillbirths in Shiga Prefecture, Japan, from 2007 to 2016 and found that only 39% of cases with fetal growth restriction (FGR) were identified antenatally. The antenatal identification of FGR was associated with the severity of growth restriction.
Objective Fetal growth restriction (FGR) is associated with perinatal adverse outcomes including intrauterine fetal death. Antenatally unidentified FGR has a higher risk of intrauterine fetal death than that identified antenatally. We, therefore, investigated the antenatal identification of FGR among intrauterine fetal deaths, and assessed the perinatal factors associated with the identification of FGR. Methods This retrospective and population-based study reviewed all stillbirths in Shiga Prefecture, Japan, from 2007 to 2016 with exclusion criteria of multiple births, births at unidentified gestational weeks or < 22 gestational weeks, and lethal disorders. We analyzed cases of FGR, using the Japanese clinical definition: Z-score of estimated fetal weight for gestational age <-1.5 standard deviations (SD). Results We identified 94 stillbirths with FGR among 429 stillbirths. Thirty-seven cases were antenatally identified during pregnancy management (39%). Dividing cases by a Z-score of -2.5 SD, 51 cases were classified as <=-2.5 SD. Twenty-eight of the 51 cases (55%) with a Z-score SD were antenatally identified as having FGR, whereas 9 of the 43 cases (21%) with a Z-score >=-2.5 SD were antenatally identified as having FGR (p = .002). Among cases with a Z-Score SD, 16 of 21 (76%) beyond 28 weeks' gestation and 12 of 30 (40%) before 28weeks' gestation were antenatally identified as having FGR (p = .023). Conclusion Fetal growth restriction leading to intrauterine fetal death in Japan was antenatally identified in less than half of cases. Antenatal identification of FGR was associated with the severity of growth restriction.
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