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Article
Biochemical Research Methods
Roozbeh Abedini-Nassab et al.
Summary: The use of magnetic micro- and nanoparticles in medicine and biology is expanding, with one important example being the transport of these particles in lab-on-a-chip systems. This study introduces a novel magnetometer using magnetic micro-disks to evaluate the magnetic susceptibility of numerous individual particles simultaneously. The method has various crucial applications, including magnetic characterization of beads and living cells, determining magnetization rate of cells, evaluating degradation rate of nanoparticles in cells, detecting target cells in samples, and separating particles based on size and magnetic susceptibility.
Article
Multidisciplinary Sciences
Sofani Tafesse Gebreyesus et al.
Summary: Single-cell proteomics can reveal cellular heterogeneity and functional networks underlying biological processes. We present a streamlined workflow combining microfluidic chips and data-independent acquisition mass spectrometry for single-cell proteomic analysis. This workflow allows for efficient isolation, counting, imaging, and sample processing of cells in a single device, enabling the analysis of protein groups in individual mammalian cells. The chip-DIA workflow provides a basis for advanced single-cell proteomics applications.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jonghwan Yoon et al.
Summary: This study introduces a magnetophoretic device with the capability of magnetic control to achieve automatic separation and selective clustering of micro-objects, which may contribute to a better understanding of the dynamics of clustered cells at the single-cell level in future cell-on-chip applications.
Article
Nanoscience & Nanotechnology
Roozbeh Abedini-Nassab et al.
Summary: In this study, we investigate the dielectrophoretic force on spherical colloidal particles exposed to an interdigitated electrode array in a microfluidic environment using theory, simulation, and experiment. Our findings demonstrate that theoretical predictions align with experimental results, and a frequency-response function for negative-dielectrophoresis instruments is derived using an equivalent electrical circuit model. Additionally, the analysis reveals that electrode width and array spacing play a crucial role in the magnitude and distance dependence of the negative dielectrophoresis force.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Multidisciplinary Sciences
Roozbeh Abedini-Nassab et al.
Summary: In this study, a fully operational microfluidic chip equipped with thin magnetic films is proposed for precise manipulation of microparticles. The chip offers high-throughput particle transport and ultra-sensitive bio-detection, and solves the challenges of particle cluster formation and background noise. It has important applications in biology.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Roozbeh Abedini-Nassab et al.
Summary: This study focuses on the precise positioning of magnetic particles and magnetized cells in a microfluidic environment. By optimizing the geometry of capacitors, a magnetic particle transport platform was designed and demonstrated, showing efficient storage and transportation of particles and cells.
Article
Multidisciplinary Sciences
Daniel Dimitrov et al.
Summary: Multiple methods and resources for inferring cell-cell communication are compared in this study, and an interface called LIANA is developed to facilitate the use and comparison of these approaches. The impact of choice of resource and method on the predicted intercellular interactions is shown, and the predictions are found to be coherent with other data modalities.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Luciano F. Huergo et al.
Summary: The study developed a simple immunoassay method for rapid, inexpensive, and quantitative detection of human antibodies against SARS-CoV-2 in serum. The method showed comparable performance to traditional ELISA and Luminex assays but required less consumables, instrumentation, time, and sample volume.
Article
Nanoscience & Nanotechnology
Meng-Jie Shen et al.
Summary: The article presents a new MACS method based on coiled-coil peptide interactions, enabling efficient cell sorting of different cell lines without the need for antigen presentation, and allowing for easy detachment of magnetic particles from cells after sorting.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Alexandre F. Aissa et al.
Summary: Tyrosine kinase inhibitors have clinical effectiveness in treating certain subsets of cancers with receptor tyrosine kinase somatic mutations, but limited duration of response and development of drug resistance are common issues. Single-cell RNA sequencing revealed multiple cancer cell subpopulations with epigenetic changes and variable therapeutic sensitivity. Overrepresented gene ontologies associated with drug tolerance include epithelial-to-mesenchymal transition, drug metabolism, and vesicle transport. Combination therapy targeting specific drug tolerant cell subpopulations shows promise in inhibiting drug resistance.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Madhav Mantri et al.
Summary: By utilizing single-cell and spatial transcriptomics in chicken hearts, the authors conducted a census of cellular interactions from early to late four-chambered heart stage, identifying a distinct epicardial-mesenchymal cell population with a migratory phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hyeonseol Kim et al.
Summary: A novel solution for disaggregation and controlled manipulation of magnetic beads is developed by using a magnetophoretic decoupler and a rotating magnetic field, allowing for enhanced functionality of lab on a chip and magnetic tweezers platforms for biological assays, intercellular interactions, and magnetic biochip systems.
Article
Multidisciplinary Sciences
Haoran Wang et al.
Summary: 3D printing microfluidic lab-on-a-chip devices allows for rapid prototyping of complex structures, with features such as optimized fiber channel design and optical trapping visualization. The device demonstrates efficient manipulation of microscopic particles and cells for various experiments.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Benjamin B. Yellen et al.
Summary: This study introduced a single-cell phenotyping tool that can measure image-based clonal properties at a large scale. By exploiting a previously unidentified flow regime in ladder microfluidic networks and using machine learning tools, researchers successfully analyzed the responses of tens of thousands of single cell-derived acute myeloid leukemia (AML) clones to targeted therapy.
Article
Engineering, Biomedical
Sandra Wiedenmann et al.
Summary: This study successfully established the single-cell characterization of the differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids using a microwell chip, and discovered secreted markers of pancreatic carcinogenesis.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemical Research Methods
Roozbeh Abedini-Nassab et al.
Summary: This study introduces a novel microfluidic platform for precise manipulation of single particles and magnetized cells, achieving simultaneous transport of multiple particles and demonstrating a curved transportation method. The technology has the potential for applications in the fields of lab-on-a-chip, single-cell biology, and drug screening.
Article
Multidisciplinary Sciences
Carlos J. Bustamante et al.
Summary: This paper introduces optical tweezers as a method for single-molecule manipulation studies, discussing in detail the physical principles, instrument characteristics, and applications. Key aspects such as calibration, operating modes, and experimental geometries of optical tweezers are explored, along with their applications in protein-nucleic acid interactions, protein/RNA folding, and molecular motors, as well as potential future trends.
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Review
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IEEE SENSORS JOURNAL
(2020)
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JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
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ADVANCED FUNCTIONAL MATERIALS
(2016)
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Biochemical Research Methods
Roozbeh Abedini-Nassab et al.
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Roozbeh Abedini-Nassab et al.
ADVANCED MATERIALS
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Byeonghwa Lim et al.
NATURE COMMUNICATIONS
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NATURE BIOTECHNOLOGY
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