4.6 Article

Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The expanding role of lyso-phosphatidylcholine acyltransferase-3 (LPCAT3), a phospholipid remodeling enzyme, in health and disease

Laurent Lagrost et al.

Summary: LPCAT3, a major lysophosphatidylcholine acyltransferase isoform, has been studied extensively in the context of cardiometabolism. Recent investigations have expanded the understanding of LPCAT3's role in other tissues such as skeletal muscle and in unexpected biological processes such as cell death and oncogenesis. The elucidation of LPCAT3's three-dimensional structure has provided further insight into the enzyme's mechanism and substrate specificity. LPCAT3 plays a critical role in skeletal muscle membrane remodeling, insulin signaling, and the process of ferroptosis. Additionally, LPCAT3 may modulate ER stress and antitumor immunity in tumor-associated macrophages. However, caution is needed in targeting LPCAT3 due to the potential deleterious effects on cell death and oncogenesis.

CURRENT OPINION IN LIPIDOLOGY (2022)

Article Multidisciplinary Sciences

Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism

Yoon Keun Cho et al.

Summary: The dysregulation of plasmalogen metabolism in adipose tissue is associated with metabolic diseases. The deletion of adipocyte TMEM86A is protective against high fat diet induced metabolic disease, and this effect can be replicated by plasmenyl lysophosphatidylethanolamine 18:0 supplementation.

NATURE COMMUNICATIONS (2022)

Article Biotechnology & Applied Microbiology

Comparison and evaluation of statistical error models for scRNA-seq

Saket Choudhary et al.

Summary: This study analyzes 59 scRNA-seq datasets to evaluate the performance of different error models in modeling variation in scRNA-seq data. The results show clear evidence of overdispersion for genes with sufficient sequencing depth, necessitating the use of a negative binomial model. The degree of overdispersion varies widely across datasets, systems, and gene abundances.

GENOME BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Article Endocrinology & Metabolism

Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity

P. Maria Clemente-Olivo et al.

Summary: The study reveals that the FHL2 gene is associated with obesity and energy metabolism. FHL2 deficiency protects mice from high-fat diet-induced weight gain while glucose handling remains normal. Enhanced energy expenditure was observed in multiple tissues.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Article Multidisciplinary Sciences

Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4

Marten A. Hoeksema et al.

Summary: The study evaluated how genetic variations in five inbred strains of mice influence macrophage responses to interleukin-4 (IL-4), revealing strain-specific patterns in gene expression induced by IL-4. Through deep learning and motif mutation analysis, the dominant combinations of transcription factors driving IL-4 enhancer activation were identified in macrophages from each strain.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

Inflammation Triggers Liver X Receptor-Dependent Lipogenesis

Sophie R. Liebergall et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Article Immunology

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Elien Grajchen et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Article Cardiac & Cardiovascular Systems

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Marie A. C. Depuydt et al.

CIRCULATION RESEARCH (2020)

Article Cell Biology

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

Josephine Mathilde Elisabeth Tan et al.

CELL REPORTS (2020)

Review Biochemistry & Molecular Biology

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease

Sudip Paul et al.

PROGRESS IN LIPID RESEARCH (2019)

Review Biochemistry & Molecular Biology

On the road to unraveling the molecular functions of ether lipids

Noemi Jimenez-Rojo et al.

FEBS LETTERS (2019)

Review Cardiac & Cardiovascular Systems

Macrophage fatty acid metabolism and atherosclerosis: The rise of PUFAs

Louise Menegaut et al.

ATHEROSCLEROSIS (2019)

Article Biochemistry & Molecular Biology

Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages

Ana Ramon-Vazquez et al.

MOLECULAR AND CELLULAR BIOLOGY (2019)

Review Endocrinology & Metabolism

Liver X receptors in lipid signalling and membrane homeostasis

Bo Wang et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

Evan D. Muse et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Medicine, Research & Experimental

ER phospholipid composition modulates lipogenesis during feeding and in obesity

Xin Rong et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Multidisciplinary Sciences

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

Emma C. L. Cook et al.

PLOS ONE (2017)

Article Biochemical Research Methods

dupRadar: a Bioconductor package for the assessment of PCR artifacts in RNA-Seq data

Sergi Sayols et al.

BMC BIOINFORMATICS (2016)

Article Cardiac & Cardiovascular Systems

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice

Aliki A. Rasmiena et al.

ATHEROSCLEROSIS (2015)

Article Biochemistry & Molecular Biology

The YhhN protein of Legionella pneumophila is a Lysoplasmalogenase

Marianne S. Jurkowitz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)

Article Biochemistry & Molecular Biology

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis

Masanori Honsho et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemical Research Methods

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides

Konstantinos D. Tsirigos et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemical Research Methods

HTSeq-a Python framework to work with high-throughput sequencing data

Simon Anders et al.

BIOINFORMATICS (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Review Biotechnology & Applied Microbiology

Liver X receptors in lipid metabolism: opportunities for drug discovery

Cynthia Hong et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Review Biochemistry & Molecular Biology

Functions of plasmalogen lipids in health and disease

Nancy E. Braverman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Biotechnology & Applied Microbiology

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

Petri Pehkonen et al.

BMC GENOMICS (2012)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Genetics & Heredity

Regulation of LPCAT3 by LXR

O. Demeure et al.

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Identification and characterization of a major liver lysophosphatidylcholine acyltransferase

Yang Zhao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

Miguel A. Gijon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

Noam Zelcer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemical Research Methods

An accurate and interpretable model for siRNA efficacy prediction

Jean-Philippe Vert et al.

BMC BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands

Chendong Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Medicine, Research & Experimental

Liver X receptors as integrators of metabolic and inflammatory signaling

N Zelcer et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Biochemistry & Molecular Biology

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

SB Joseph et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport

NJ Munn et al.

JOURNAL OF LIPID RESEARCH (2003)

Article Cell Biology

Role of LXRs in control of lipogenesis

JR Schultz et al.

GENES & DEVELOPMENT (2000)

Article Multidisciplinary Sciences

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

A Venkateswaran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)