期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 237, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2022.111984
关键词
Vanadium; Oxidovanadium compounds; 8-hydroxyquinolines; Speciation chemistry; coordination complexes; M; smegmatis
资金
- Agencia Nacional de Investigacion e Innovacion (ANII, Uruguay) [9404]
- Comision Academica de Posgrado-UdelaR
- Colorado State University
- [MOV_CA_2020_1_162704]
The antiproliferative effects of VIVO and VVO based compounds on M. smeg and T. cruzi were investigated, and it was found that M. smeg showed weaker response to these compounds compared to T. cruzi.
The antiproliferative effects of four series of VIVO-and VVO-based compounds containing 8-hydroxyquinoline ligands on the bacterium Mycolicibacterium smegmatis (M. smeg) were investigated. The effects on M. smeg were compared to the antiproliferative effects on the protozoan parasite Trypanosoma cruzi (T. cruzi), the causative agent for Chagas disease. In this study, we investigate the speciation of these compounds under physiological conditions as well as the antiproliferative effects on the bacterium M. smeg. We find that the complexes are more stable the less H2O is present, and that the stability increases in lipid-like environments. Only one heteroleptic complex and two homoleptic complexes were found to show similar antiproliferative ef-fects on M. smeg as reported for T. cruzi so the responses generally observed by M.smeg. is less than observed by the pathogen. In summary, we find that M. smeg is more sensitive to the detailed structure of the V-complex but overall these complexes are less effective against M. smeg compared to T. cruzi.
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