期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 237, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2022.112026
关键词
Mn complex; Biomimetic catalyst; Click chemistry; Mesoporous silica; SOD activity; Spectroscopy
资金
- National University of Rosario [PI BIO553]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PIP 0852, PUE 0068]
- Centre National de la Recherche Scientifique (CNRS) [PICS 07121]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT-2019-03276]
A mononuclear Mn(III) complex with a clickable ligand was synthesized and covalently attached to modified mesoporous silica materials using click chemistry. The catalyst exhibited high catalytic rate for the dismutation of superoxide in aqueous medium, and the hybrid materials showed good stability and recyclability.
A mononuclear Mn(III) complex of a clickable ligand, [Mn(hbpapn)(H2O)(2)]ClO4 center dot 4.5H(2)O, where H(2)hbpapn = 1,3-bis[(2-hydroxybenzyl)(propargyl)amino]propane, has been prepared and fully characterized. The complex catalyzes the dismutation of superoxide employing a Mn(III)/Mn(IV) redox cycle, with catalytic rate constant of 3.9 x 10(6) M-1 s(-1) determined through the nitro blue tetrazolium photoreduction inhibition assay, in aqueous medium of pH 7.8. The alkyne function of the ligand was used for the covalent attachment of the catalyst to azide modified mesoporous silicas with different texture and morphology, through click chemistry. In these materials the catalyst is essentially linked to the inner pore walls, isolated and protected from the external medium. The hybrid materials can be recycled, and retain or improve the superoxide dismutase activity of the free catalyst with the pore size of the solid matrix playing a role on the activity of the catalyst.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据