Photophysical, photobiological, and biomolecule-binding properties of new tri-cationic meso-tri(2-thienyl)corroles with Pt(II) and Pd(II) polypyridyl derivatives

We report the synthesis and characterization of new tri-cationic corrole derivatives, containing Pt(II) or Pd(II) complexes attached at the peripheral position of thienyl moieties. Corrole derivatives were characterized through microanalysis, electrochemical, spectrometry and spectroscopy analysis. Singlet and triplet excited-states are investigated by photophysical/theoretical calculation methods and photobiological parameters were also eval-uated spectroscopic techniques (UV-Vis and EPR). Also, the binding capacity of each corrole derivative with nucleic acids (DNA) and human serum albumin (HSA) was determined by UV-Vis, steady-state, and time -resolved fluorescence spectroscopy, combined with molecular docking analysis. Moreover, the new corroles containing peripheral complexes improve their interactions with biomacromolecules, generate reactive oxygen species under light source irradiation studied and has potential for application in photodynamic therapeutic processes.

Automated summary

This study synthesized and characterized new tri-cationic corrole derivatives that contained Pt(II) or Pd(II) complexes attached at the peripheral position of thienyl moieties. The corrole derivatives were characterized through various analysis techniques. Photophysical and theoretical calculations were used to investigate the singlet and triplet excited states, and spectroscopic techniques were used to evaluate the photobiological parameters. The binding capacity of the corrole derivatives with nucleic acids and human serum albumin was determined, and their potential for application in photodynamic therapeutic processes was studied.