4.2 Article

Acquired B-cell deficiency secondary to B-cell-depleting therapies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

B cell-activating factor and its targeted therapy in autoimmune diseases

Yidan Zhang et al.

Summary: B cells play a pivotal role in autoimmune diseases, and B cell-activating factor (BAFF) is key in driving autoreactive B cell response. Increased BAFF levels have been observed in patients with autoimmune diseases and mouse models where autoantibody production is prominent. Recent clinical studies have shown BAFF as a potential therapeutic target for treating autoimmune diseases.

CYTOKINE & GROWTH FACTOR REVIEWS (2022)

Article Allergy

Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees

Iris M. Otani et al.

Summary: Secondary hypogammaglobulinemia is characterized by reduced immunoglobulin levels due to decreased antibody production or increased loss. It is important to determine whether the hypogammaglobulinemia is secondary or primary for evaluation and management. Patients with a history of immunosuppressive medications or conditions associated with SHG require thorough investigation to determine the underlying causes and devise effective treatment plans. When iatrogenic causes cannot be removed or underlying conditions cannot be reversed, monitoring for clinical infections, supportive antimicrobials, and immunoglobulin replacement therapy may be considered.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Clinical Neurology

Long-term efficacy and safety of inebilizumab in neuromyelitis optica spectrum disorder: Analysis of aquaporin-4-immunoglobulin G-seropositive participants taking inebilizumab for > 4 years in the N-MOmentum trial

Mary Rensel et al.

Summary: Long-term inebilizumab treatment in AQP4-IgG-seropositive patients with neuromyelitis optica spectrum disorder showed a low annualized attack rate, stable disability scores, and good tolerability. Levels of Immunoglobulin G decreased over time, but no clear correlation with severe infections was determined. The study continues to support the use of inebilizumab for this disorder, and suggests potential enhanced efficacy with longer treatment duration.

MULTIPLE SCLEROSIS JOURNAL (2022)

Review Clinical Neurology

Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases

Panos Stathopoulos et al.

Summary: B cells play an important role in the etiology of autoimmune neurological disorders, acting as antigen-presenting cells and regulating the immune response. Depletion of B cells has become a promising treatment strategy. This paper summarizes the basic aspects of B cell biology, discusses the roles of B cells in neurological autoimmunities, and highlights the efficacy and practical considerations of anti-B cell therapies in different neurological disorders.

NEUROTHERAPEUTICS (2022)

Article Clinical Neurology

AQP4-IgG-seronegative patient outcomes in the N-MOmentum trial of inebilizumab in neuromyelitis optica spectrum disorder

Romain Marignier et al.

Summary: This study reported the outcomes of AQP4- participants in NMOSD. Only 36% of AQP4 screened participants were considered eligible for randomization. The study evaluated MOG-IgG serology and annualized attack rates, and assessed efficacy by comparing pre-study and on-study AARs.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Review Oncology

Newly approved anti-CD19 monoclonal antibodies for the treatment of relapsed or refractory diffuse large B-cell lymphoma

James A. Davis et al.

Summary: This article summarizes the background, clinical trials, and place in therapy for the first two anti-CD19 monoclonal antibodies that have been recently FDA approved for patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). These novel therapies have started to change management strategies and outcomes for these patients. However, the place in therapy and sequencing of these agents can present a challenge to prescribers, especially for patients being evaluated for CD19 targeting CAR T-cell therapy.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2022)

Review Clinical Neurology

Anti-CD20 therapies for multiple sclerosis: current status and future perspectives

Monica Margoni et al.

Summary: Multiple sclerosis is a chronic disease affecting the central nervous system, and recent advancements in immune pathophysiology have led to the identification of selective B-cell-depleting therapies like anti-CD20 monoclonal antibodies, which have shown strong efficacy and safety in treating MS. This has expanded the therapeutic options for both relapsing and progressive MS patients, highlighting the important role of B cells in the disease process.

JOURNAL OF NEUROLOGY (2022)

Review Immunology

CD19-Targeted Immunotherapies for Diffuse Large B-Cell Lymphoma

Massimiliano Gambella et al.

Summary: Surgical resection, chemotherapy, and radiotherapy have been the primary cancer treatments for a long time. Recently, immune checkpoint inhibitors and adoptive cell therapies have emerged as promising alternatives. These therapies aim to activate and utilize the patient's immune system to fight against cancer cells, and have shown remarkable results.

FRONTIERS IN IMMUNOLOGY (2022)

Review Cell Biology

CD20+ T cells: an emerging T cell subset in human pathology

Adrian Y. S. Lee

Summary: Although CD20 is primarily known as a B cell marker, it has been observed in a subset of T cells as well. These CD20(+)T cells appear to express more inflammatory cytokines and markers of effector function compared to CD20(-)T cells. The current understanding is that CD20 may be acquired from B cells through trogocytosis. CD20(+)T cells can be found in various diseases including autoimmune diseases, malignancies, and HIV infections. Multiple sclerosis is one of the best-studied diseases where CD20(+)T cells are found and therapeutic interventions targeting CD20 have shown promise in depleting these cells.

INFLAMMATION RESEARCH (2022)

Article Infectious Diseases

Successful use of casirivimab/imdevimab anti-spike monoclonal antibodies to enhance neutralizing antibodies in a woman on anti-CD20 treatment with refractory COVID-19

Yusuke Miyazato et al.

Summary: This case describes a COVID-19 patient with humoral immunodeficiency who experienced multiple relapses due to anti-CD20 monoclonal antibody treatment. The patient was successfully treated with casirivimab/imdevimab and developed neutralizing antibodies. This suggests that monoclonal antibodies have therapeutic and prophylactic value in patients with humoral immunodeficiency.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2022)

Review Immunology

Immunogenicity of Monoclonal Antibodies and the Potential Use of HLA Haplotypes to Predict Vulnerable Patients

Romy Mosch et al.

Summary: This review discusses ADA formation of mAbs and its clinical impact, as well as proposes the use of HLA haplotypes as biomarkers to predict patients' susceptibility to ADA formation.

FRONTIERS IN IMMUNOLOGY (2022)

Article Rheumatology

New-onset hypogammaglobulinaemia and infectious complications associated with rituximab use in childhood-onset rheumatic diseases

Mei Sing Ong et al.

Summary: Rituximab treatment for childhood-onset rheumatic diseases can lead to hypogammaglobulinaemia and infectious complications, with steroid therapy and age as significant risk factors.

RHEUMATOLOGY (2022)

Article Immunology

Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficiency patients

Francesca Schena et al.

Summary: DADA2 patients show decreased memory B cells, particularly in class switch memory, and an expansion of CD21(low)B cells. In vitro stimulated B lymphocytes can secrete nonfunctional ADA2 protein, suggesting a cell intrinsic defect leading to impaired B-cell proliferation and differentiation. Additionally, CD4(+) and CD8(+) T cells are reduced, while circulating T follicular helper cells are significantly increased but have impaired IL-21 production, potentially contributing to impaired B cell help.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Rheumatology

COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study

Jerome Avouac et al.

Summary: Rituximab therapy is associated with more severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases, and should be prescribed with caution.

LANCET RHEUMATOLOGY (2021)

Article Transplantation

Rituximab Desensitization in Liver Transplant Recipients With Preformed Donor-specific HLA Antibodies: A Japanese Nationwide Survey

Nobuhisa Akamatsu et al.

Summary: Rituximab induction was well tolerated among DSA-positive liver transplant recipients with a dose >300 mg/m(2) observed to achieve a lower incidence of antibody-mediated rejection. The study found a higher rate of infusion-related adverse drug reactions but all of them were mild and self-limiting, with no severe adverse events associated with rituximab reported.

TRANSPLANTATION DIRECT (2021)

Article Rheumatology

Incidence, Clinical Features, and Outcomes of Late-Onset Neutropenia From Rituximab for Autoimmune Disease

Reza Zonozi et al.

Summary: Late-onset neutropenia (LON) is a common and often incidental complication of rituximab treatment, with systemic lupus erythematosus and combination therapy with cyclophosphamide being independently associated with an increased risk of LON. Most episodes are asymptomatic, but fever and sepsis can complicate a significant proportion of cases. Filgrastim is commonly used for treatment, and recurrence of LON can occur in a subset of patients following rituximab rechallenge. Vigilant monitoring is warranted due to the potential for serious infections.

ARTHRITIS & RHEUMATOLOGY (2021)

Article Medicine, General & Internal

Effectiveness of Belimumab After Rituximab in Systemic Lupus Erythematosus A Randomized Controlled Trial

Muhammad Shipa et al.

Summary: In patients with refractory systemic lupus erythematosus (SLE), the use of belimumab following rituximab significantly reduced serum IgG anti-dsDNA antibody levels and decreased the risk of severe disease flares, suggesting the potential for this combination as a therapeutic strategy.

ANNALS OF INTERNAL MEDICINE (2021)

Article Surgery

Association of antiviral prophylaxis and rituximab use with posttransplant lymphoproliferative disorders (PTLDs): A nationwide cohort study

Laura N. Walti et al.

Summary: Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation (SOT), mostly associated with Epstein-Barr virus (EBV) infection. The role of antiviral prophylaxis or rituximab therapy in preventing PTLD in SOT recipients is controversial. However, receiving rituximab as induction treatment was associated with a significantly longer PTLD-free survival time in patients.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Article Immunology

Intrinsic Defects in B Cell Development and Differentiation, T Cell Exhaustion and Altered Unconventional T Cell Generation Characterize Human Adenosine Deaminase Type 2 Deficiency

Jin Yan Yap et al.

Summary: The study conducted in-depth immunophenotyping and functional analysis of human lymphocytes in ten patients with DADA2, revealing defects in B cell differentiation, impaired memory T cell differentiation, and increased inflammatory monocytes and immature NK cells. The findings shed light on the complex immune phenotype of DADA2 and suggest the need for targeted therapy to prevent viral infections and excessive inflammation in these patients.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

Article Rheumatology

Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Anja Strangfeld et al.

Summary: Factors associated with COVID-19-related death in people with rheumatic diseases include age, sex, comorbidities, disease activity, and specific medications. Adequate disease control with disease-modifying anti-rheumatic drugs (DMARDs) without increasing glucocorticoid dosages is important, while caution may be required with certain medications such as rituximab and sulfasalazine.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Multidisciplinary Sciences

CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties

Martijn Vlaming et al.

Summary: CD20-positive T cells play a significant role in both autoimmunity and cancer, with studies showing that they possess various functional properties such as enhanced activation and reduced transmigration.

SCIENTIFIC REPORTS (2021)

Review Immunology

COVID-19 in B Cell-Depleted Patients After Rituximab: A Diagnostic and Therapeutic Challenge

Anna Furlan et al.

Summary: The study demonstrates significant effects of B cell-depleting agents on adaptive immunity, which should be considered in the selection of SARS-CoV-2 diagnostics and guiding therapeutic approaches. Combination therapeutic strategies may play a crucial role in the setting of B cell immune deficiencies.

FRONTIERS IN IMMUNOLOGY (2021)

Article Allergy

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients

Roxane Labrosse et al.

Summary: The study revealed a high prevalence of hypogammaglobulinemia in children receiving rituximab treatment, with low IgG levels associated with an increased risk of serious infections. Underlying primary immunodeficiencies were relatively common in pediatric patients receiving rituximab.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Rheumatology

Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry

Jeffrey A. Sparks et al.

Summary: This study investigated the baseline use of biologic or targeted synthetic disease-modifying antirheumatic drugs and COVID-19 outcomes in patients with rheumatoid arthritis. The results showed that patients treated with rituximab or Janus kinase inhibitors were associated with worse COVID-19 severity, emphasizing the need for prioritizing risk mitigation strategies for these individuals.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Review Pediatrics

Use of rituximab in paediatric nephrology

Rajiv Sinha et al.

Summary: Rituximab is a chimeric monoclonal antibody that can deplete B cells, originally used in oncology but later found effective for rheumatological conditions and kidney diseases, and has gained significant interest in pediatric nephrology in recent years.

ARCHIVES OF DISEASE IN CHILDHOOD (2021)

Review Rheumatology

Coronavirus disease 2019: update on coronavirus disease 2019 outcomes and vaccine efficacy in patients with immune-mediated inflammatory disease

Jeffrey A. Sparks et al.

Summary: Although literature on COVID-19 outcomes in immune-mediated inflammatory disease patients has been generally reassuring, there are still many unanswered questions. Individual factors such as glucocorticoid use and disease activity are associated with severe COVID-19 outcomes, while specific medications like tumor necrosis factor inhibitors and rituximab have varying associations. Studies also offer important insights into antibody response after COVID-19 vaccination for patients with immune-mediated inflammatory diseases.

CURRENT OPINION IN RHEUMATOLOGY (2021)

Article Pediatrics

X-Linked Agammaglobulinemia Presenting as Neutropenia: Case Report and an Overview of Literature

Mosopefoluwa Lanlokun et al.

Summary: Early evaluation for primary humoral immune deficiency in male patients under 12 months with neutropenia can help avoid unnecessary bone marrow biopsy in stable cases.

FRONTIERS IN PEDIATRICS (2021)

Article Hematology

Single-nucleotide Fcγ receptor polymorphisms do not impact obinutuzumab/rituximab outcome in patients with lymphoma

Jonathan C. Strefford et al.

Summary: This study demonstrates that Fc gamma R genotype is not associated with response to rituximab/obinutuzumab plus chemotherapy in treatment-naive patients with advanced FL or DLBCL.

BLOOD ADVANCES (2021)

Article Hematology

Prognostic significance of FCGR2B expression for the response of DLBCL patients to rituximab or obinutuzumab treatment

Malgorzata Nowicka et al.

Summary: The study suggests that higher FCGR2B expression in DLBCL patients can reduce drug efficacy and is associated with shorter progression-free survival in R-CHOP treatment. High FCGR2B expression may promote responsiveness to R-CHOP treatment compared to G-CHOP treatment.

BLOOD ADVANCES (2021)

Article Rheumatology

Hypogammaglobulinemia after rituximab for rheumatoid arthritis is not rare and is related with good response: 13 years real-life experience

Gerasimos Evangelatos et al.

Summary: The study found that 43% of rheumatoid arthritis patients treated with RTX developed HGG. Patients who developed low IgG or low IgM had lower baseline levels than those who did not, and the development of low IgM was associated with better disease outcomes.

RHEUMATOLOGY (2021)

Article Allergy

Rituximab Unveils Hypogammaglobulinemia and Immunodeficiency in Children with Autoimmune Cytopenia

Giorgio Ottaviano et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Review Immunology

Post-rituximab immunoglobulin M (IgM) hypogammaglobulinemia

Khalaf Kridin et al.

AUTOIMMUNITY REVIEWS (2020)

Review Rheumatology

Effects of rituximab therapy on B cell differentiation and depletion

L. Bergantini et al.

CLINICAL RHEUMATOLOGY (2020)

Article Allergy

A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

Isabella Quinti et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Review Immunology

Hepatitis B Virus Reactivation Potentiated by Biologics

Eiichi Ogawa et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2020)

Article Medicine, General & Internal

Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus

Lennard Ostendorf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Immunology

Management of PTLD After Hematopoietic Stem Cell Transplantation: Immunological Perspectives

Francesca Compagno et al.

FRONTIERS IN IMMUNOLOGY (2020)

Letter Allergy

Three patients with X-linked agammaglobulinemia hospitalized for COVID-19 improved with convalescent plasma

Haoli Jin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

Review Neurosciences

Anti-CD20 Agents for Multiple Sclerosis: Spotlight on Ocrelizumab and Ofatumumab

Despoina Florou et al.

BRAIN SCIENCES (2020)

Article Biophysics

Early and late hematologic toxicity following CD19 CAR-T cells

Shalev Fried et al.

BONE MARROW TRANSPLANTATION (2019)

Review Immunology

B cells in chronic graft-versus-host disease

William McManigle et al.

HUMAN IMMUNOLOGY (2019)

Review Rheumatology

2019 update of the EULAR recommendations for the management of systemic lupus erythematosus

Antonis Fanouriakis et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

Article Medicine, General & Internal

Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values

Pierluigi Marzuillo et al.

WORLD JOURNAL OF CLINICAL CASES (2019)

Review Immunology

B cell targeted therapies in autoimmune disease

Jennifer L. Barnas et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

Review Clinical Neurology

B-Cell Therapy for Multiple Sclerosis: Entering an Era

Ariele L. Greenfield et al.

ANNALS OF NEUROLOGY (2018)

Review Hematology

A tale of two antibodies: obinutuzumab versus rituximab

Ciara L. Freeman et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Article Medicine, General & Internal

Primary Sjogren's Syndrome

Xavier Mariette et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity

Edward A. Clark et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Medicine, General & Internal

Rituximab and Fibrillary Glomerulonephritis: Interest of B Cell Reconstitution Monitoring

Claire Leibler et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Article Clinical Neurology

Monitoring B-cell repopulation after depletion therapy in neurologic patients

Erik Ellwardt et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2018)

Article Medicine, General & Internal

Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia

Sara Barmettler et al.

JAMA NETWORK OPEN (2018)

Review Immunology

Risk factors predisposing to the development of hypogammaglobulinemia and infections post-Rituximab

Evangelos A. A. Christou et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2017)

Review Allergy

Update on the use of immunoglobulin in human disease: A review of evidence

Elena E. Perez et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Medicine, Research & Experimental

B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy

John F. Beausang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Review Chemistry, Medicinal

Current perspective on rituximab in rheumatic diseases

Tommaso Schioppo et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

Review Medicine, Research & Experimental

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience

Gilles Salles et al.

ADVANCES IN THERAPY (2017)

Article Immunology

Features of Human CD3+CD20+ T Cells

Elisabeth Schuh et al.

JOURNAL OF IMMUNOLOGY (2016)

Letter Allergy

Continuing IgG replacement therapy for hypogammaglobulinemia after rituximab-for how long?

Sara Barmettler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Medicine, General & Internal

Hypogammaglobulinaemia after rituximab treatment-incidence and outcomes

M. Makatsori et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2014)

Article Rheumatology

Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

Ronald F. van Vollenhoven et al.

ANNALS OF THE RHEUMATIC DISEASES (2012)

Article Hematology

Rituximab resistance

Andrew R. Rezvani et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2011)

Review Infectious Diseases

Does rituximab increase the incidence of infectious complications? A narrative review

Theodoros Kelesidis et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2011)

Editorial Material Hematology

A gut feeling about plasmablasts

David Tarlinton

Article Rheumatology

Longterm Safety of Patients Receiving Rituximab in Rheumatoid Arthritis Clinical Trials

Ronald F. van Vollenhoven et al.

JOURNAL OF RHEUMATOLOGY (2010)

Article Medicine, General & Internal

Rituximab and intravenous immune globulin for desensitization during renal transplantation

Ashley A. Vo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Multidisciplinary Sciences

Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice

Jean-David Bouaziz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Medical Laboratory Technology

Rare-event analysis in flow cytometry

Albert D. Donnenberg et al.

CLINICS IN LABORATORY MEDICINE (2007)

Article Immunology

B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny

Jennifer H. Anolik et al.

CLINICAL IMMUNOLOGY (2007)