Transcription factor AP-2 gamma/Kruppel-like factor 10 axis is involved in miR-3656-related dysfunction of endothelial cells in hypertension

Article Oncology

Anlotinib inhibits the proliferation, migration and invasion, and induces apoptosis of breast cancer cells by downregulating TFAP2C

Fuxiao Fang et al.

Summary: Anlotinib suppresses proliferation, migration, and invasion, while inducing apoptosis, in breast cancer cells. The inhibition of TFAP2C expression may partially explain its mechanism of action.

ONCOLOGY LETTERS (2022)

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Article Biochemistry & Molecular Biology

Elevated Expression of JMJD5 Protein Due to Decreased miR-3656 Levels Contributes to Cancer Stem Cell-Like Phenotypes under Overexpression of Cancer Upregulated Gene 2

Natpaphan Yawut et al.

Summary: Overexpression of CUG2 leads to the occurrence of cancer stem cell-like phenotypes, mainly by decreasing the levels of miR-3656 and upregulating JMJD5.

BIOMOLECULES (2022)

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Article Peripheral Vascular Disease

Circulating miR-3656 induces human umbilical vein endothelial cell injury by targeting eNOS and ADAMTS13: a novel biomarker for hypertension

Jikang Shi et al.

Summary: This study found that miR-3656 is upregulated in patients with hypertension and inhibits the proliferation, migration, and angiogenesis of HUVECs while promoting apoptosis. The direct target genes of miR-3656 are eNOS and ADAMTS13, and overexpression of these genes can abolish the effects of miR-3656 on HUVECs.

JOURNAL OF HYPERTENSION (2022)

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Article Peripheral Vascular Disease

Circulating miR-3135b and miR-107 are potential biomarkers for severe hypertension

Jikang Shi et al.

Summary: Circulating molecules play a role in hypertension, with miR-3135b and miR-107 identified as differentially expressed miRNAs in plasma between patients with severe hypertension and healthy controls. The target genes regulated by these two miRNAs are notably different, suggesting they may serve as potential biomarkers for severe hypertension.

JOURNAL OF HUMAN HYPERTENSION (2021)

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Review Peripheral Vascular Disease

MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction

Ji-Ru Zhang et al.

Summary: Hypertension, a multifactorial disorder, involves the dysregulation of vascular smooth muscle cells (VSMCs) which play a crucial role in the development of systemic hypertension and pulmonary arterial hypertension (PAH). Noncoding RNAs (ncRNAs) are emerging as novel modulators in the biological behaviors of VSMCs, with microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs being recommended as predictive biomarkers and therapeutic targets for hypertension and PAH.

HYPERTENSION RESEARCH (2021)

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Article

MicroRNAs Involved in Oxidative Stress Processes Regulating Physiological and Pathological Responses

Yongjie Xu et al.

MicroRNA (Shariqah, United Arab Emirates) (2021)

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Article Oncology

Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling

Junhao Liu et al.

Summary: PELP1 has been identified as a novel interacting protein of TFAP2C, and both factors regulate a set of genes that affect the progression of breast cancer.

MOLECULAR ONCOLOGY (2021)

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Correction Oncology

MiR-10a-5p targets TFAP2C to promote gemcitabine resistance in pancreatic ductal adenocarcinoma (vol 37, 76, 2018)

Guangbing Xiong et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Fragile Gene WWOX Guides TFAP2A/TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer

Damian Kolat et al.

Summary: This study investigated the roles of WWOX, AP-2 alpha, and AP-2 gamma in bladder cancer, with results showing that co-overexpression of WWOX and AP-2 alpha can suppress tumor effects, and a similar effect can be achieved through their interaction with AP-2 gamma.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Fucosyltransferase 8 regulation and breast cancer suppression by transcription factor activator protein 2γ

Minxing Ma et al.

Summary: The study found that in breast cancer, miR-10b positively regulates FUT8 expression by regulating AP-2gamma, which in turn affects cell invasion and migration ability. AP-2gamma can bind to STAT3, inhibit STAT3 phosphorylation, prevent its entry into the nucleus, and thus suppress FUT8 transcription.

CANCER SCIENCE (2021)

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Correction Oncology

Fragile Gene WWOX Guides TFAP2A/TFAP2C-Dependent Actions Against Tumor Progression in Grade II Bladder Cancer

Damian Kolat et al.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

LncRNA RP11-84E24.3 drives tumorigenesis and epithelial-to-mesenchymal transition of glioma cells by promoting TFAP2C-mediated activation of SNAI1

Lisha Chang et al.

Summary: LncRNA RP11-84E24.3 is up-regulated in glioma tissues and cell lines, promoting epithelial-to-mesenchymal transition and tumor formation in glioma cells by increasing SNAI1 expression through forming a complex with TFAP2C protein.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway

Yuan Jin et al.

Summary: In this study, it was found that the upregulation of miR-3566 in exosomes released by CAFs can enhance the proliferation and invasion of ESCC cells by suppressing ACAP2, leading to the activation of the PI3K/AKT and beta-catenin signaling pathways. This discovery provides a potential therapeutic target for ESCC and a new basis for clinical treatment plans.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Medicine, General & Internal