Green multicomponent approach to novel 5-[(2H-Pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidines

The multicomponent green methodologies are an ideal instrument in organic synthesis. Environmentally benign, facile, and efficient multicomponent synthesis of [(2H-pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidines by the reaction of aromatic aldehydes, N,N '-dimethylbarbituric acid and 4-hydroxy-6-methyl-2H-pyran-2-one employing simple and eco-friendly catalyst and solvent-sodium acetate and ethanol is reported. The reaction proceeds at reflux conditions with good and excellent yields (65%-97%). The isolation of final compounds does not require complex purification procedures. All novel synthesized compounds are characterized by H-1 and C-13 NMR spectroscopy, FT-IR and mass spectrometry, and elemental analysis. The [(2H-pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidine structure was proven using 2D NMR spectroscopy methods.

Automated summary

Multicomponent green methodologies play an important role in organic synthesis by efficiently synthesizing compounds using simple and environmentally friendly catalysts and solvents, without the need for complex purification procedures.