期刊
JOURNAL OF HEPATOLOGY
卷 78, 期 5, 页码 979-988出版社
ELSEVIER
DOI: 10.1016/j.jhep.2023.01.013
关键词
autoimmune liver disease; liver transplantation; prothrombin ratio; treatment withdrawal
This study reports the treatment outcomes and long-term prognosis of children with autoimmune hepatitis. The results show that the prognosis of type 2 hepatitis is similar to that of type 1 hepatitis. Withdrawal of treatment is possible, but patients with persistent abnormal prothrombin ratio may require liver transplantation in adolescence or early adulthood.
Background & Aims: In children with autoimmune hepatitis, uncertainties include outcomes associated with type 2 hepatitis, the possibility of and criteria for attempting withdrawal of treatment, and long-term outcomes. We report our experience on these issues. Methods: From 1973 to 2002, 117 children with type 1 (n = 65) or type 2 (n = 52) hepatitis, excluding fulminant hepatitis, were treated, primarily with prednisone and azathioprine. Median follow-up was 20 years in survivors.Results: Normalisation of aminotransferases and prothrombin ratio were observed in 93% and 84% of children, respectively; sustained remission after treatment withdrawal was recorded in 24% of the entire population, with a median follow-up of 7 years. Sustained treatment-free remission was obtained in 11 of 24 children with follow-ups of 4-22 years based on durable normal-isation of aminotransferases (without histological assessment). Gastrointestinal bleeding from varices and the emergence of extrahepatic autoimmune disorders occurred in 10 and 22 patients, respectively. Liver transplantation was performed in 23 pa-tients at a median age of 21 years. The 30-year probabilities of overall and native liver survival were 81% and 61%, respectively. No differences were observed between type 1 and 2 hepatitis for any of the component parts of outcome. In the multivariate analysis, a persistent abnormal prothrombin ratio was associated with worse probabilities of overall and native liver survival.Conclusions: In terms of liver outcome, type 2 hepatitis is not different from type 1. Withdrawal of treatment is possible without prior liver histology. A persistent abnormal prothrombin ratio identifies patients who will require liver transplantation in adoles-cence or early adulthood.(c) 2023 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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