相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Tumor-Cell-Specific Targeting of Ibrutinib: Introducing Electrostatic Antibody-Inhibitor Conjugates (AiCs)
Andreas Faust et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)
Strategies for targeting undruggable targets
Gong Zhang et al.
EXPERT OPINION ON DRUG DISCOVERY (2022)
Targeted siRNA nanocarrier: a platform technology for cancer treatment
Nicole Baeumer et al.
ONCOGENE (2022)
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment
Seong Keun Kim et al.
FRONTIERS IN PHARMACOLOGY (2022)
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2021)
Identifying of biomarkers associated with gastric cancer based on 11 topological analysis methods of CytoHubba
Hua Ma et al.
SCIENTIFIC REPORTS (2021)
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
Linde Schoenmaker et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)
Identification of Hub Genes and Their Correlation With Immune Infiltration Cells in Hepatocellular Carcinoma Based on GEO and TCGA Databases
Rui Huang et al.
FRONTIERS IN GENETICS (2021)
MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models
Douglas D. Fang et al.
CELL DEATH DISCOVERY (2021)
Clinical relevance of clonal hematopoiesis in persons aged ≥80 years
Marianna Rossi et al.
BLOOD (2021)
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response
Marina Scheller et al.
NATURE CANCER (2021)
5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis
Sha Jin et al.
CLINICAL CANCER RESEARCH (2020)
Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia
Christopher A. Eide et al.
LEUKEMIA (2020)
A phase II study of siG12D-LODER in combination with chemotherapy in patients with locally advanced pancreatic cancer (PROTACT).
Anna M. Varghese et al.
JOURNAL OF CLINICAL ONCOLOGY (2020)
Protamine loops DNA in multiple steps
Obinna A. Ukogu et al.
NUCLEIC ACIDS RESEARCH (2020)
DNA Methyltransferases in Cancer: Biology, Paradox, Aberrations, and Targeted Therapy
Jiayu Zhang et al.
CANCERS (2020)
Advances in oligonucleotide drug delivery
Thomas C. Roberts et al.
NATURE REVIEWS DRUG DISCOVERY (2020)
Antibody-Drug Conjugates: The Last Decade
Nicolas Joubert et al.
PHARMACEUTICALS (2020)
Therapeutic siRNA: state of the art
Bo Hu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
A guide to cancer immunotherapy: from T cell basic science to clinical practice
Alex D. Waldman et al.
NATURE REVIEWS IMMUNOLOGY (2020)
The current state and future directions of RNAi-based therapeutics
Ryan L. Setten et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Clinical Experience With Ibrutinib Alone or in Combination With Either Cytarabine or Azacitidine in Patients With Acute Myeloid Leukemia
Jorge E. Cortes et al.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2019)
A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3AR882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis
Rui Lu et al.
CANCER RESEARCH (2019)
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Jude Canon et al.
NATURE (2019)
Identification of potential ibrutinib combinations in hematological malignancies using a combination high-throughput screen
Michael Schaffer et al.
LEUKEMIA & LYMPHOMA (2018)
Bcl-2 on the brink of breakthroughs in cancer treatment
John C. Reed
CELL DEATH AND DIFFERENTIATION (2018)
A multiprotein supercomplex controlling oncogenic signalling in lymphoma
James D. Phelan et al.
NATURE (2018)
Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth
Nicole Baeumer et al.
PLOS ONE (2018)
GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
Aaron D. Springer et al.
NUCLEIC ACID THERAPEUTICS (2018)
FLT3 inhibitors in acute myeloid leukemia
Mei Wu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
Functional genomic landscape of acute myeloid leukaemia
Jeffrey W. Tyner et al.
NATURE (2018)
DNMT3A in Leukemia
Lorenzo Brunetti et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Midostaurin for the treatment of acute myeloid leukemia
Mrinal M. Patnaik
FUTURE ONCOLOGY (2017)
Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
R. M. Stone et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis
Sabah F. Chaudry et al.
BIOMED RESEARCH INTERNATIONAL (2017)
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression
David H. Spencer et al.
CELL (2017)
Implementing Genome-Driven Oncology
David M. Hyman et al.
CELL (2017)
Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown
Nicole Baeumer et al.
NATURE PROTOCOLS (2016)
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
Maggie L. Bobbin et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia
Klaus H. Metzeler et al.
BLOOD (2016)
Acute myeloid leukemia: a comprehensive review and 2016 update
I. De Kouchkovsky et al.
BLOOD CANCER JOURNAL (2016)
DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia
Sara E. Meyer et al.
CANCER DISCOVERY (2016)
Global Cancer Statistics, 2012
Lindsey A. Torre et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2015)
Antibody-Mediated Delivery of Anti-KRAS-siRNA In Vivo Overcomes Therapy Resistance in Colon Cancer
Sebastian Baeumer et al.
CLINICAL CANCER RESEARCH (2015)
Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia
Rosemary E. Gale et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
HTSeq-a Python framework to work with high-throughput sequencing data
Simon Anders et al.
BIOINFORMATICS (2015)
STRING v10: protein-protein interaction networks, integrated over the tree of life
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2015)
cytoHubba: identifying hub objects and sub-networks from complex interactome
Chia-Hao Chin et al.
BMC SYSTEMS BIOLOGY (2014)
The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers
David A. Russler-Germain et al.
CANCER CELL (2014)
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat
Juan Martinez-Olivan et al.
FEBS JOURNAL (2014)
Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen Keegan et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Michael I. Love et al.
GENOME BIOLOGY (2014)
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)
Verena I. Gaidzik et al.
BLOOD (2013)
Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
Teresa Coelho et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia
Felicitas Thol et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression
Qing Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine
Young-Suk Choi et al.
BIOMATERIALS (2010)
DNMT3A Mutations in Acute Myeloid Leukemia.
Timothy J. Ley et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
Ji Luo et al.
CELL (2009)
An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Lars Zender et al.
CELL (2008)
The role of Gemtuzumab Ozogamicin in the treatment of acute myeloid leukemia patients
L. Pagano et al.
ONCOGENE (2007)
Common phylogenetic origin of protamine-like (PL) proteins and histone H1:: Evidence from bivalve PL genes
Jose M. Eirin-Lopez et al.
MOLECULAR BIOLOGY AND EVOLUTION (2006)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
A Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
EW Song et al.
NATURE BIOTECHNOLOGY (2005)
Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity
I Jedema et al.
LEUKEMIA (2004)
Formation of native-like mammalian sperm cell chromatin with folded bull protamine
ID Vilfan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cytoscape: A software environment for integrated models of biomolecular interaction networks
P Shannon et al.
GENOME RESEARCH (2003)