Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

Article Hematology

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

Melissa M. Berrien-Elliott et al.

Summary: Using IL-15 for allogeneic cellular therapy may paradoxically limit therapeutic efficacy as it accelerates CD8 T-cell activation, leading to rejection of donor NK cells.

BLOOD (2022)

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Letter Immunology

Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

Bokyung Min et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Hematology

CD38 knocKout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

Mark Gurney et al.

Summary: There is strong biological rationale for combining alloeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to improve the targeting of acute myeloid leukemia (AML). However, CD38 expression on NK cells and its induction during ex vivo NK cell expansion pose challenges to the development of a CD38 CAR-NK cell therapy. This study successfully used gene editing technology to reduce CD38 expression in expanded NK cells, resulting in reduced fratricide and enhanced targeting of primary AML cells. Additionally, pretreatment of AML cells with all-trans retinoic acid further augmented the cytotoxic potential of CD38 CAR-NK cells. These findings support the investigation of CD38 knockdown - CD38 CAR-NK cells as a promising immunotherapeutic approach for AML treatment.

HAEMATOLOGICA (2022)

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Article Oncology

Improved Outcome in Children With Newly Diagnosed High-Risk Neuroblastoma Treated With Chemoimmunotherapy: Updated Results of a Phase II Study Using hu14.18K322A

Wayne L. Furman et al.

Summary: Combining hu14.18K322A with chemotherapy improves early response and outcomes in high-risk neuroblastoma. This treatment is well-tolerated and reduces tumor volume in most patients, leading to improved end-of-induction response rates and encouraging 3-year event-free survival.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Cell Biology

Natural Receptor- and Ligand-Based Chimeric Antigen Receptors: Strategies Using Natural Ligands and Receptors for Targeted Cell Killing

Gianna M. Branella et al.

Summary: This article discusses the success of CAR T-cell therapy in treating B-cell malignancies and the issues in CAR design. It explores the advantages and disadvantages of scFv-based and natural receptor- or ligand-based CAR designs. Additionally, it examines the translational aspects of natural receptor- and ligand-based CAR approaches being investigated in preclinical and clinical studies.

CELLS (2022)

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Article Biotechnology & Applied Microbiology

CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model

Yu Yang Ng et al.

Summary: The study demonstrates that the co-expression of CXCR4 and anti-BCMA CAR on NK cells is an effective way to control MM progression by enhancing NK cell infiltration into the bone marrow and reducing tumor burden, leading to prolonged survival of patients.

CANCER GENE THERAPY (2022)

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Article Oncology

Decrease post-transplant relapse using donor-derived expanded NK-cells

Stefan O. Ciurea et al.

Summary: In this phase I/II clinical trial, high doses of mb-IL21 ex vivo expanded donor-derived NK cells were administered to 25 patients with myeloid malignancies undergoing haploidentical stem-cell transplantation. The results showed a significant decrease in the relapse rate and improved disease-free survival compared to the control group, with a particular benefit in patients without donor-specific anti-HLA antibodies. The administration of expanded NK cells post-transplantation was safe and led to NK cell-dominant immune reconstitution, preserved T-cell reconstitution, and better clinical outcomes.

LEUKEMIA (2022)

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Article Biotechnology & Applied Microbiology

Human placental hematopoietic stem cell derived natural killer cells (CYNK-001) mediate protection against influenza a viral infection

Joseph Gleason et al.

Summary: The study found that adoptively transferred NK cells derived from stem cells can combat influenza A virus (IAV) infections. These cells have antiviral and anti-inflammatory properties, which can alleviate the disease burden and delay mortality. In addition, this treatment also alters immune responses, reducing inflammatory cells while increasing immune cells during viral infections. Therefore, the use of NK cell therapy for IAV infections warrants clinical investigation.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

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Review Immunology

Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy

Mubin Tarannum et al.

Summary: This article summarizes the key challenges and innovative strategies in the clinical application of natural killer cell research.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Engineering Induced Pluripotent Stem Cells for Cancer Immunotherapy

Yang Zhou et al.

Summary: Cell-based immunotherapy has revolutionized the treatment of hematological malignancies, but obstacles remain in the widespread clinical applications of current autologous therapies. Human induced pluripotent stem cells offer a potential solution by providing a scalable source for cell therapy, and recent advances have been made in using these cells for immune therapy, particularly in combination with CAR-engineering.

CANCERS (2022)

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Review Genetics & Heredity

Regulatory Considerations for Clinical Trial Applications with CRISPR-Based Medicinal Products

Brigitte Anliker et al.

Summary: CRISPR technology has shown great potential in addressing incurable genetic diseases, but its clinical development requires regulatory oversight and adaptation to ensure safety and efficacy. Discussing both scientific and regulatory considerations is crucial for advancing CRISPR-based products towards clinical trials, especially in countries like Germany.

CRISPR JOURNAL (2022)

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Review Oncology

Natural killer cells in antitumour adoptive cell immunotherapy

Tamara J. Laskowski et al.

Summary: This review provides an overview of NK cell-based immunotherapies, discussing strategies to increase NK cell cytotoxicity and persistence and highlighting the current challenges and future opportunities for the design of next-generation NK cell therapies.

NATURE REVIEWS CANCER (2022)

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Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Meeting Abstract Hematology

Allogeneic, CD34+, Umbilical CordbloodDerived NK Cell Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia Patients with Measurable Residual Disease

Michael Heuser et al.

BLOOD (2021)

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Meeting Abstract Hematology

Gda-201, a Novel Metabolically Enhanced Allogeneic Natural Killer (NK) Cell Product Yields High Remission Rates in Patients with Relapsed/Refractory NonHodgkin Lymphoma (NHL): 2-Year Survival and Correlation with Cytokine IL7

Veronika Bachanova et al.

BLOOD (2021)

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Meeting Abstract Hematology

Phase I Study of FT516, an Off-the-Shelf iPSC-Derived NK Cell Therapy, in Combination with Rituximab in Patients with Relapsed/Refractory B-Cell Lymphoma

Krish Patel et al.

BLOOD (2021)

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Meeting Abstract Hematology

A Pilot Phase I Trial of IL-21 Expanded IdealDonor Natural Killer (NK) Cells in Combination with Mogamulizumab in Patients with Cutaneous T-Cell Lymphomas (CTCL) or Adult T-Cell Leukemia/Lymphomas (ATLL)

Basem M. William et al.

BLOOD (2021)

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Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells

Melita Irving et al.

Summary: CAR-T cell therapy shows great potential for treating B cell malignancies, but translating it to other tumor types remains a challenge. Research is ongoing to develop more sophisticated methods and tools for engineering T cells to overcome limitations of traditional viral vectors.

HUMAN GENE THERAPY (2021)

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Review Immunology

Engineering NK Cells for CAR Therapy-Recent Advances in Gene Transfer Methodology

Paula Schmidt et al.

Summary: The development of CAR-NK cells allows for harnessing the innate anti-tumor ability of NK cells against target tumor antigens, with the potential for creating an off-the-shelf therapeutic product applicable to most patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Implications of hematopoietic stem cells heterogeneity for gene therapies

Jeremy Epah et al.

Summary: Hematopoietic stem cell transplantation (HSCT) is a therapeutic concept for curing blood/immune system diseases, but carries significant risks. Gene modified autologous HSC transplantation shows promise for treating blood/immune cell diseases, but the observed heterogeneity of HSCs in situ and ex vivo has important implications for gene therapy development and manufacturing.

GENE THERAPY (2021)

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Article Oncology

Optimizing the Procedure to Manufacture Clinical-Grade NK Cells for Adoptive Immunotherapy

Adrian Fernandez et al.

Summary: NK cells have shown promise in cancer immunotherapy, and an NK cell activation-expansion process was optimized and validated on a clinical scale in this study. Various cell culture media and artificial antigen presenting cells were used to obtain GMP-grade NK cells suitable for clinical use. NK cells derived from PBMC yielded higher purity and total cell numbers compared to CD45RA(+) cells, and the use of K562mbIL21-41BBL cells resulted in the highest fold expansion and NK purity.

CANCERS (2021)

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Article Hematology

Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells

Kenneth P. Micklethwaite et al.

Summary: A phase 1 clinical trial using CAR T cells produced with the piggyBac transposon system resulted in the development of malignant lymphomas in two patients. One patient died as a result of the CAR T-cell derived lymphoma. The study highlights the importance of caution and regular follow-up in CAR T recipients, particularly when novel gene transfer methods are employed.

BLOOD (2021)

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Article Hematology

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

David C. Bishop et al.

BLOOD (2021)

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Article Oncology

Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies

Lucila N. Kerbauy et al.

Summary: The study suggests that using bispecific engagers and cytokine pre-activation can enhance NK-cell cytotoxicity against NK-resistant cancers. Additionally, there are differences in treatment response based on the source of NK cells.

CLINICAL CANCER RESEARCH (2021)

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Article Cell & Tissue Engineering

Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma

Astrid Tschan-Plessl et al.

Summary: The study demonstrates the feasibility and safety of haploidentical NK cell infusions as consolidation immunotherapy after ASCT in patients with plasma cell myeloma. By manufacturing high numbers of activated NK cells for multiple-dose infusions, the treatment showed expected effects without evidence of graft-versus-host disease.

CYTOTHERAPY (2021)

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Review Cell & Tissue Engineering

Infusion reactions in natural killer cell immunotherapy: a retrospective review

Tewodros Mamo et al.

Summary: This study retrospectively analyzed infusion reactions associated with NK cell infusions, finding that most patients experienced grade 1 or 2 reactions, while a minority experienced grade 3 reactions mainly involving the cardiovascular system. Monocyte dose was associated with headaches and cardiovascular reactions, suggesting its significance in enhancing therapeutic outcomes.

CYTOTHERAPY (2021)

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Review Immunology

Current Perspectives on Off-The-Shelf Allogeneic NK and CAR-NK Cell Therapies

Erica L. Heipertz et al.

Summary: Natural killer (NK) cells are a crucial part of the immune system, with the ability to kill virally infected and malignant cells. Current research is focused on testing the efficacy of NK cell therapy for cancer and exploring the use of CAR-NK for treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

piggyBac system to co-express NKG2D CAR and IL-15 to augment the in vivo persistence and anti-AML activity of human peripheral blood NK cells

Zhicheng Du et al.

Summary: Significant progress has been made in adoptive transfer of CAR-modified NK cells for treating relapsed or refractory AML. The co-expression of NKG2D CAR and IL-15 in NK cells enhances anti-leukemic activity and offers a promising approach for AML therapy.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

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Review Oncology

The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy

Kellsye P. Fabian et al.

Summary: This review outlines the importance of NK cells in cancer treatment and the development of NK-92 cell line in CAR-engineering, demonstrating robust antitumor activity and potential as a next-generation off-the-shelf cell therapy platform.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Meeting Abstract Oncology

NICOTINAMIDE REJUVENATES EX-VIVO EXPANDED NATURAL KILLER CELLS AND ENHANCES THEIR TUMOR KILLING CAPACITY

Aviad Pato et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Meeting Abstract Oncology

DEVELOPMENT OF WU-NK-101, A FEEDER CELL-FREE EXPANDED ALLOGENEIC MEMORY NK CELL PRODUCT WITH POTENT ANTI-TUMOR ACTIVITY

Ryan Sullivan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Ying Gong et al.

Summary: NK cells, especially CAR-NK cells, play a crucial role in cancer treatment. Advances in CAR-NK technology show promising potential in efficiently targeting cancer cells with reduced side effects. These developments contribute to improving cancer treatment strategies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Biochemical Research Methods

Lymphocyte expansion in bioreactors: upgrading adoptive cell therapy

Oscar Fabian Garcia-Aponte et al.

Summary: Bioreactors are crucial for developing efficient cell therapy products, but face challenges in realizing their full potential. Research has identified requirements for bioreactor design and discussed the applicability and challenges of current technologies.

JOURNAL OF BIOLOGICAL ENGINEERING (2021)

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Review Oncology

Cryopreservation of NK and T Cells Without DMSO for Adoptive Cell-Based Immunotherapy

Xue Yao et al.

Summary: DMSO, commonly used as a cryoprotectant in clinical adoptive cell therapy, has broad toxicities and is associated with various clinical side effects in patients. Developing alternatives to DMSO for cryopreservation of NK and T cells remains challenging due to their sensitivity to freezing and thawing.

BIODRUGS (2021)

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Review Hematology

Graft-versus-host disease risk after chimeric antigen receptor T-cell therapy: the diametric opposition of T cells

Khaled Sanber et al.

Summary: CAR T-cell therapy has revolutionized the treatment of hematologic malignancies, but also introduced potential toxicities, including the risk of graft-versus-host disease (GVHD) in certain settings. Understanding and managing this risk is crucial for the safe development and use of CAR T-cell therapies in clinical practice.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Cell & Tissue Engineering

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

Karrune Woan et al.

Summary: Researchers have successfully generated a NK cell subset called iADAPT by editing induced pluripotent stem cells, which exhibited persistence in vivo and superior antitumor activity. This finding suggests that unique subsets of the immune system can be modeled through iPSC technology, providing a new approach for treating patients with advanced cancer.

CELL STEM CELL (2021)

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Review Cell & Tissue Engineering

Advances in automated cell washing and concentration

Anqi Li et al.

Summary: Successful commercialization of cell therapies requires careful planning and consideration of various factors. Automation plays a crucial role in achieving robust and reproducible manufacturing processes at an industrial scale. Understanding the characteristics and limitations of wash-and-concentrate devices is essential for optimizing cell therapy manufacturing.

CYTOTHERAPY (2021)

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Meeting Abstract Oncology

Preliminary data from QUILT 3.055: A phase 2 multi-cohort study of N803 (IL-15 superagonist) in combination with checkpoint inhibitors (CPI).

John M. Wrangle et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Meeting Abstract Oncology

Trial in progress: Open-label, randomized, comparative phase 2/3 study of combination immunotherapy plus standard-of-care chemotherapy and SBRT versus standard-of-care chemotherapy for the treatment of locally advanced or metastatic pancreatic cancer.

Tara Elisabeth Seery et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Review Cell & Tissue Engineering

Comparability: what we can learn from the review of advanced therapy medicinal products

Alexis Cockroft et al.

Summary: This study evaluated publicly available summaries and reports to explore regulators' expectations for comparability data in gene and cell therapy products. The research found deficiencies, additional information requests, and major objections related to comparability in some approved products. Post-approval authorization obligations were imposed on six products, highlighting the importance of comparability data in regulatory applications.

REGENERATIVE MEDICINE (2021)

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Article Oncology

A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

Michelle K. Becker-Hapak et al.

Summary: NK cells show promise as a cellular therapy for cancer, but challenges in production of required reagents exist. A novel HFPC platform was developed to activate NK cells against cancer, showing potential for advancement in clinical GMP-grade memory-like NK cell production.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Oncology

A Novel off-the-Shelf Trastuzumab-Armed NK Cell Therapy (ACE1702) Using Antibody-Cell-Conjugation Technology

Hao-Kang Li et al.

Summary: This study aims to develop an off-the-shelf natural killer cell therapy using Antibody-Cell Conjugation (ACC) technology against HER2-expressing cancers. The ACE1702, trastuzumab-armed oNK cells, showed superior potency against HER2-expressing cancer cells in vitro and in vivo without tumorigenic potential. This suggests the potential clinical application of ACC technology for providing off-the-shelf therapies for cancer patients.

CANCERS (2021)

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Article Biotechnology & Applied Microbiology

One-Time Optimization of Advanced T Cell Culture Media Using a Machine Learning Pipeline

Paul Grzesik et al.

Summary: This study successfully implemented a machine learning pipeline into the design of cell culture media, resulting in a one-time optimized T cell culture medium, which is advantageous for optimizing heterogeneous biological material.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

Ana L. Portillo et al.

Summary: The study shows that HER2 CAR-NK cells enhance anti-tumor functions against HER2-expressing cancer cells without affecting non-malignant cells, suggesting a promising and safe immunotherapy option for solid tumors.

ISCIENCE (2021)

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Review Cell & Tissue Engineering

Selecting a Cell Engineering Methodology During Cell Therapy Product Development

Lauren M. Timmins et al.

Summary: This review emphasizes the importance of considering consistency in product design, selection of genetic modification methods, key risks, and clinical implications when developing genetically modified cell therapy products. Developers need to fully understand the potential risks of cell engineering methods and the importance of clinical application.

CELL TRANSPLANTATION (2021)

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Review Biochemistry & Molecular Biology

iPSC-Derived Natural Killer Cells for Cancer Immunotherapy

Peter Karagiannis et al.

Summary: The discovery of human pluripotent stem cells (PSCs) has led to the exploration of induced pluripotent stem cells (iPSCs) as a potential universal cell source for therapies, including cancer immunotherapies using natural killer (NK cells). iPSCs offer advantages in quality and flexibility compared to primary NK cells, and there are various protocols for genetic modification and differentiation into NK cells. However, there are challenges that need to be addressed before iPSC-based NK cell immunotherapies can become mainstream in clinical settings.

MOLECULES AND CELLS (2021)

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Article Biophysics

Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors

Jan Styczynski et al.

BONE MARROW TRANSPLANTATION (2020)

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Article Hematology

Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Huang Zhu et al.

BLOOD (2020)

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Review Biotechnology & Applied Microbiology

NK cells for cancer immunotherapy

Noriko Shimasaki et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

An off the shelf, GMP compliant,fully closed and semi-automated large-scale production system for allogeneic NK cells

J. Veluchamy

CYTOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM)

Farzaneh Sharifzad et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

Pembrolizumab plus allogeneic NK cells in advanced non-small cell lung cancer patients

Mao Lin et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Oncology

APOLLO: A phase I study of adaptive memory natural killer (NK) cells in recurrent ovarian cancer.

Melissa Ann Geller et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Review Cell & Tissue Engineering

Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?

Maooz Awan et al.

REGENERATIVE MEDICINE (2020)

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Article Oncology

Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial

Rosa Nguyen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Oncology

PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations

Kellsye P. Fabian et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Cell Biology

Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold

Kento Fujiwara et al.

CELLS (2020)

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Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cell & Tissue Engineering

Evaluation of serum -free media formulations in feeder cell stimulated expansion of natural killer cells

Jena E. Moseman et al.

CYTOTHERAPY (2020)

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Article Cell & Tissue Engineering

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

Huang Zhu et al.

CELL STEM CELL (2020)

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Article Medicine, Research & Experimental

Vector Copy Distribution at a Single-Cell Level Enhances Analytical Characterization of Gene-Modified Cell Therapies

Ilaria Santeramo et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Article Biochemistry & Molecular Biology

A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis

Chengui Lu et al.

MOLECULAR IMMUNOLOGY (2020)

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Review Biochemical Research Methods

Challenges and advantages of cell therapy manufacturing under Good Manufacturing Practices within the hospital setting

Emanuela M. Iancu et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

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Article Medicine, Research & Experimental

Sleeping Beauty engineered CAR T cells achieve antileukemic activity without severe toxicities

Chiara F. Magnani et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Medicine, General & Internal

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

Jeremy S. Abramson et al.

LANCET (2020)

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Review Immunology

Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function

Simone Mantesso et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Oncology

The Tumor Microenvironment-A Metabolic Obstacle to NK Cells' Activity

Joanna Domagala et al.

CANCERS (2020)

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Meeting Abstract Hematology

A Phase 1 Study of the Combination of MG4101, Ex Vivo-Expanded Allogeneic NK Cells and Rituximab for Relapsed or Refractory Non-Hodgkin Lymphoma

Dok Hyun Yoon et al.

BLOOD (2020)

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Meeting Abstract Hematology

Experience with Continuous Infusion of Recombinant Porcine FVIII in Patients with Acquired Hemophilia a

Daniel Lindsay et al.

BLOOD (2020)

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Meeting Abstract Hematology

A Phase 1 Study of NKX101, an Allogeneic CAR Natural Killer (NK) Cell Therapy, in Subjects with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-Risk Myelodysplastic Syndrome (MDS)

Carlos Bachier et al.

BLOOD (2020)

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Meeting Abstract Hematology

Results of a Phase 1 Trial of Gda-201, Nicotinamide-Expanded Allogeneic Natural Killer (NK) Cells in Patients with Refractory Non-Hodgkin Lymphoma (NHL) and Multiple Myeloma

Veronika Bachanova et al.

BLOOD (2020)

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Article Cell Biology

iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy

Frank Cichocki et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Medicine, General & Internal

Intraperitoneal infusion of ex vivo-cultured allogeneic NK cells in recurrent ovarian carcinoma patients (a phase I study)

Janneke Hoogstad-van Evert et al.

MEDICINE (2019)

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Article Biotechnology & Applied Microbiology

Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients

Lin Xiao et al.

MOLECULAR THERAPY (2019)

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Review Biochemistry & Molecular Biology

The role of cytokines in the regulation of NK cells in the tumor environment

Gordana M. Konjevic et al.

CYTOKINE (2019)

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Review Medicine, Research & Experimental

Genetically engineered CAR T-immune cells for cancer therapy: recent clinical developments, challenges, and future directions

Sherien M. El-Daly et al.

JOURNAL OF APPLIED BIOMEDICINE (2019)

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Article Oncology

2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies

Yingxi Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Cell Biology

Mechanisms of natural killer cell-mediated cellular cytotoxicity

Isabel Prager et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Laurent Gauthier et al.

CELL (2019)

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Review Immunology

Cellular therapy: Adoptive immunotherapy with expanded natural killer cells

Dean A. Lee

IMMUNOLOGICAL REVIEWS (2019)

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Article Biotechnology & Applied Microbiology

Preparation of highly activated natural killer cells for advanced lung cancer therapy

Silun Xie et al.

ONCOTARGETS AND THERAPY (2019)

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Review Immunology

The Natural Cytotoxicity Receptors in Health and Disease

Alexander David Barrow et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities

Weilei Hu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell & Tissue Engineering

Preservation of cell-based immunotherapies for clinical trials

Rui Li et al.

CYTOTHERAPY (2019)

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Article Biotechnology & Applied Microbiology

Towards robust cell culture processes - Unraveling the impact of media preparation by spectroscopic online monitoring

Matthias Brunner et al.

ENGINEERING IN LIFE SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity

Shengnan Yu et al.

MOLECULAR CANCER (2019)

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Article Oncology

358PComplete responses in patients with second-line or greater metastatic triple negative breast cancer (TNBC) following first-in-human immunotherapy combining NK and T cell activation with off-the-shelf high-affinity CD16 NK cell line (haNK)

C Nangia et al.

ANNALS OF ONCOLOGY (2019)

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Article Oncology

Robo1-specific CAR-NK Immunotherapy Enhances Efficacy of 125I Seed Brachytherapy in an Orthotopic Mouse Model of Human Pancreatic Carcinoma

Ning Xia et al.

ANTICANCER RESEARCH (2019)

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Meeting Abstract Hematology

Results of a Phase I Study of Pnk-007, Allogeneic, Off the Shelf NK Cell, Post Autologous Transplant in Multiple Myeloma (NCT02955550)

Sarah A. Holstein et al.

BLOOD (2019)

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Article Biochemistry & Molecular Biology

Structure-based rational design of a novel chimeric PD1-NKG2D receptor for natural killer cells

Changjiang Guo et al.

MOLECULAR IMMUNOLOGY (2019)

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Article Surgery

Engraftment of mesothelin chimeric antigen receptor using a hybrid Sleeping Beauty/minicircle vector into NK-92MI cells for treatment of pancreatic cancer

Ramesh B. Batchu et al.

SURGERY (2019)

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Article Multidisciplinary Sciences

Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells

Evelyn O. Ojo et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

Culturing the Human Natural Killer Cell Line NK-92 in Interleukin-2 and Interleukin-15-Implications for Clinical Trials

Heidi Tornroos et al.

ANTICANCER RESEARCH (2019)

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Review Oncology

Teaching an old dog new tricks: next-generation CAR T cells

Nicholas Tokarew et al.

BRITISH JOURNAL OF CANCER (2019)

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Meeting Abstract Hematology

FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies

Jode P. Goodridge et al.

BLOOD (2019)

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Article Oncology

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial

Frederick L. Locke et al.

LANCET ONCOLOGY (2019)

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Article Oncology

NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors

Robin Parihar et al.

CANCER IMMUNOLOGY RESEARCH (2019)

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Meeting Abstract Oncology

A Phase I study of PNK-007, allogeneic, off the shelf NK cell in relapsed/refractory AML (NCT02781467)

Sarah Cooley et al.

CANCER RESEARCH (2019)

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Review Oncology

Technical advances in NK cell-based cellular immunotherapy

Fang Fang et al.

CANCER BIOLOGY & MEDICINE (2019)

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Article Oncology

Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity

E. Liu et al.

LEUKEMIA (2018)

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Article Hematology

Advances in the use of natural receptor-or ligand-based chimeric antigen receptors (CARs) in haematologic malignancies

Joana M. Murad et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2018)

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Article Cell & Tissue Engineering

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

Ye Li et al.

CELL STEM CELL (2018)

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Article Medicine, Research & Experimental

In Vivo Study of Natural Killer (NK) Cell Cytotoxicity Against Cholangiocarcinoma in a Nude Mouse Model

In Hye Jung et al.

IN VIVO (2018)

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Article Cell Biology

Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells

Katja Srpan et al.

JOURNAL OF CELL BIOLOGY (2018)

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Article Oncology

ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial

John M. Wrangle et al.

LANCET ONCOLOGY (2018)

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Article Biotechnology & Applied Microbiology

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

Keishi Adachi et al.

NATURE BIOTECHNOLOGY (2018)

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Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Medicine, Research & Experimental

Fetal Bovine Serum (FBS): Past - Present - Future

Jan van der Valk et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2018)

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Article Biotechnology & Applied Microbiology

Rapid expansion in the WAVE bioreactor of clinical scale cells for tumor immunotherapy

Yiming Meng et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Article Oncology

Adoptive immunotherapy with haploidentical natural killer cells and Anti-GD2 monoclonal antibody m3F8 for resistant neuroblastoma: Results of a phase I study

Shakeel Modak et al.

ONCOIMMUNOLOGY (2018)

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Article Oncology

In situ delivery of allogeneic natural killer cell (NK) combined with Cetuximab in liver metastases of gastrointestinal carcinoma: A phase I clinical trial

O. Adotevi et al.

ONCOIMMUNOLOGY (2018)

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Article Immunology

Pharmacologically upregulated carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer cells

Masayuki Shiozawa et al.

BMC IMMUNOLOGY (2018)

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Article Oncology

Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment

Kelong Tao et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2018)

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Article Cell Biology

Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome

Mohammed Alnaggar et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Oncology

Strategies to Address Chimeric Antigen Receptor Tonic Signaling

Adam Ajina et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Article Biotechnology & Applied Microbiology

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Sarwish Rafiq et al.

NATURE BIOTECHNOLOGY (2018)

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Article Immunology

Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy

Bokyung Min et al.

IMMUNE NETWORK (2018)

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Review Medicine, General & Internal

Commercial Scale Manufacturing of Allogeneic Cell Therapy

Gary M. Pigeau et al.

FRONTIERS IN MEDICINE (2018)

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Article Oncology

Haploidentical natural killer cells induce remissions in non-Hodgkin lymphoma patients with low levels of immune-suppressor cells

Veronika Bachanova et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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Review Chemistry, Multidisciplinary

Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy

Yuan Hu et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Article Oncology

Clinical grade manufacturing of genetically modified, CAR-expressing NK-92 cells for the treatment of ErbB2-positive malignancies

Paulina Nowakowska et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

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Review Biotechnology & Applied Microbiology

Allogeneic cell therapy manufacturing: process development technologies and facility design options

Saeed Abbasalizadeh et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2017)

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Review Immunology

The Broad Spectrum of Human Natural Killer Cell Diversity

Aharon G. Freud et al.

IMMUNITY (2017)

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Article Oncology

ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody

Caroline Jochems et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Medicine, Research & Experimental

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming

Julia A. Wagner et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Review Biotechnology & Applied Microbiology

Engineering Natural Killer Cells for Cancer Immunotherapy

Katayoun Rezvani et al.

MOLECULAR THERAPY (2017)

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Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Biotechnology & Applied Microbiology

Comparison of autogeneic and allogeneic natural killer cells immunotherapy on the clinical outcome of recurrent breast cancer

Shuzhen Liang et al.

ONCOTARGETS AND THERAPY (2017)

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Article Biotechnology & Applied Microbiology

Development of the First World Health Organization Lentiviral Vector Standard: Toward the Production Control and Standardization of Lentivirus-Based Gene Therapy Products

Yuan Zhao et al.

HUMAN GENE THERAPY METHODS (2017)

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Review Immunology

Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation

Markus Granzin et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Immunology

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer immunotherapy: Recent innovations and Future Developments

John P. Veluchamy et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Oncology

GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity

Frank Cichocki et al.

CANCER RESEARCH (2017)

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Article Oncology

A Pilot Trial of Humanized Anti-GD2 Monoclonal Antibody (hu14.18K322A) with Chemotherapy and Natural Killer Cells in Children with Recurrent/Refractory Neuroblastoma

Sara M. Federico et al.

CLINICAL CANCER RESEARCH (2017)

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Article Hematology

Consolidation Therapy for Newly Diagnosed Pediatric Patients with High-Risk Neuroblastoma Using Busulfan/Melphalan, Autologous Hematopoietic Cell Transplantation, Anti-GD2 Antibody, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-2, and Haploidentical Natural Killer Cells

Aimee C. Talleur et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2017)

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Article Oncology

Successful Transfer of Umbilical Cord Blood CD34+ Hematopoietic Stem and Progenitor-derived NK Cells in Older Acute Myeloid Leukemia Patients

Harry Dolstra et al.

CLINICAL CANCER RESEARCH (2017)

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Article Cell & Tissue Engineering

Natural killer cells differentiated in vitro from cord blood CD34+ cells are more advantageous for use as an immunotherapy than peripheral blood and cord blood natural killer cells

Anna Domogala et al.

CYTOTHERAPY (2017)

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Article Hematology

Phase I study of cord blood-derived natural killer cells combined with autologous stem cell transplantation in multiple myeloma

Nina Shah et al.

BRITISH JOURNAL OF HAEMATOLOGY (2017)

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Review Cell & Tissue Engineering

A consensus introduction to serum replacements and serum-free media for cellular therapies

Ohad Karnieli et al.

CYTOTHERAPY (2017)

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Article Cell & Tissue Engineering

Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer

David L. Hermanson et al.

STEM CELLS (2016)

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Article Oncology

Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival

Sabrina Genssler et al.

ONCOIMMUNOLOGY (2016)

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Article Hematology

Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia

Inpyo Choi et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2016)

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Review Biophysics

Aptamers, antibody scFv, and antibody Fab' fragments: An overview and comparison of three of the most versatile biosensor biorecognition elements

Victor Crivianu-Gaita et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Article Oncology

Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Antonio Curti et al.

CLINICAL CANCER RESEARCH (2016)

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Article Cell & Tissue Engineering

Natural killer cells stimulated with PM21 particles expand and biodistribute in vivo: Clinical implications for cancer treatment

Jeremiah L. Oyer et al.

CYTOTHERAPY (2016)

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Review Hematology

IL-2, IL-7, and IL-15: Multistage regulators of CD4+ T helper cell differentiation

Kaitlin A. Read et al.

EXPERIMENTAL HEMATOLOGY (2016)

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Article Medicine, General & Internal

Cord-Blood Transplantation in Patients with Minimal Residual Disease

Filippo Milano et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Oncology

An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele

Caroline Jochems et al.

ONCOTARGET (2016)

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Review Immunology

Natural Killer Cells for immunotherapy-Advantages of the NK-92 Cell Line over Blood NK Cells

Hans Klingemann et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Article Hematology

Infusion of a non-HLA-matched ex-vivo expanded cord blood progenitor cell product after intensive acute myeloid leukaemia chemotherapy: a phase 1 trial

Colleen Delaney et al.

LANCET HAEMATOLOGY (2016)

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Review Oncology

CAR models: next-generation CAR modifications for enhanced T-cell function

Daniel Abate-Daga et al.

MOLECULAR THERAPY-ONCOLYTICS (2016)

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Article Medicine, Research & Experimental

Serum-free cell culture: the serum-free media interactive online database

Daniel Brunner

ALTEX-Alternatives to Animal Experimentation (2016)

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Article Cell & Tissue Engineering

Fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy

Markus Granzin et al.

CYTOTHERAPY (2015)

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Article Immunology

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma

Nadja Müller et al.

JOURNAL OF IMMUNOTHERAPY (2015)

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Article Oncology

Ex Vivo-expanded Natural Killer Cells Demonstrate Robust Proliferation In Vivo in High-risk Relapsed Multiple Myeloma Patients

Susann Szmania et al.

JOURNAL OF IMMUNOTHERAPY (2015)

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Article Medicine, Research & Experimental

Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer

Naoyuki Sakamoto et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

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Article Biochemistry & Molecular Biology

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long et al.

NATURE MEDICINE (2015)

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Article Oncology

Natural killer cell therapy in children with relapsed leukemia

Jeffrey E. Rubnitz et al.

PEDIATRIC BLOOD & CANCER (2015)

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Article Cell & Tissue Engineering

The Aryl Hydrocarbon Receptor Antagonist StemRegenin1 Improves In Vitro Generation of Highly Functional Natural Killer Cells from CD34+ Hematopoietic Stem and Progenitor Cells

Mieke W. H. Roeven et al.

STEM CELLS AND DEVELOPMENT (2015)

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Review Immunology

Heat shock protein 70 (Hsp70) peptide activated Natural Killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx) - from preclinical studies to a clinical phase II trial

Hanno M. Specht et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Hematology

Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation

Nirali N. Shah et al.

BLOOD (2015)

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Article Multidisciplinary Sciences

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

Jianfeng Han et al.

SCIENTIFIC REPORTS (2015)

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Review Biochemistry & Molecular Biology

Understanding of molecular mechanisms in natural killer cell therapy

Suk Ran Yoon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2015)

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Article Hematology

Donor-Derived Natural Killer Cells Infused after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation: A Dose-Escalation Study

Inpyo Choi et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2014)

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Article Hematology

Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells

Jeffrey W. Leong et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2014)

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Article Hematology

Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15

Masaru Imamura et al.

BLOOD (2014)

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Article Hematology

Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein

Veronika Bachanova et al.

BLOOD (2014)

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Article Oncology

CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

J. Chu et al.

LEUKEMIA (2014)

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Article Biotechnology & Applied Microbiology

Ultra-low Dose Interleukin-2 Promotes Immune-modulating Function of Regulatory T Cells and Natural Killer Cells in Healthy Volunteers

Sawa Ito et al.

MOLECULAR THERAPY (2014)

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Article Hematology

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

Rizwan Romee et al.

BLOOD (2013)

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Article Engineering, Chemical

Integrated Clinical Scale Manufacturing System for Cellular Products Derived by Magnetic Cell Separation, Centrifugation and Cell Culture

Michael Apel et al.

CHEMIE INGENIEUR TECHNIK (2013)

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Article Oncology

Irradiated and Activated Autologous PBMCs Induce Expansion of Highly Cytotoxic Human NK Cells In Vitro

Yong-Oon Ahn et al.

JOURNAL OF IMMUNOTHERAPY (2013)

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Article Medicine, General & Internal

Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia

Stephan A. Grupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Multidisciplinary Sciences

GMP-Compliant, Large-Scale Expanded Allogeneic Natural Killer Cells Have Potent Cytolytic Activity against Cancer Cells In Vitro and In Vivo

Okjae Lim et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

Nina Shah et al.

PLOS ONE (2013)

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Article Cell & Tissue Engineering

Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

David A. Knorr et al.

STEM CELLS TRANSLATIONAL MEDICINE (2013)

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Article Education, Scientific Disciplines

Therapeutic applications: natural killer cells in the clinic

Jeffrey S. Miller

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2013)

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Article Hematology

Cytokine activation induces human memory-like NK cells

Rizwan Romee et al.

BLOOD (2012)

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Article Oncology

Controlled-rate freezer cryopreservation of highly concentrated peripheral blood mononuclear cells results in higher cell yields and superior autologous T-cell stimulation for dendritic cell-based immunotherapy

Timo Buhl et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

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Review Immunology

Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy

Martha Luevano et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2012)

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Article Cell & Tissue Engineering

Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications

Natalia Lapteva et al.

CYTOTHERAPY (2012)

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Article Immunology

The unique profile of cord blood natural killer cells balances incomplete maturation and effective killing function upon activation

Martha Luevano et al.

HUMAN IMMUNOLOGY (2012)

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Article Multidisciplinary Sciences

Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

Cecele J. Denman et al.

PLOS ONE (2012)

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Review Cell & Tissue Engineering

Concise Review: Genomic Stability of Human Induced Pluripotent Stem Cells

Kristen Martins-Taylor et al.

STEM CELLS (2012)

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Review Cell & Tissue Engineering

Concise Review: Cell Therapies: The Route to Widespread Adoption

Lucy Foley et al.

STEM CELLS TRANSLATIONAL MEDICINE (2012)

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Review Immunology

Targeting natural killer cells and natural killer T cells in cancer

Eric Vivier et al.

NATURE REVIEWS IMMUNOLOGY (2012)

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Article Hematology

IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect

Don M. Benson et al.

BLOOD (2011)

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Article Cell & Tissue Engineering

Establishment, Characterization, and Successful Adaptive Therapy Against Human Tumors of NKG Cell, a New Human NK Cell Line

Min Cheng et al.

CELL TRANSPLANTATION (2011)

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Article Oncology

Phase I Trial of ALT-801, an Interleukin-2/T-Cell Receptor Fusion Protein Targeting p53 (aa264-272)/HLA-A*0201 Complex, in Patients with Advanced Malignancies

Mayer N. Fishman et al.

CLINICAL CANCER RESEARCH (2011)

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Article Oncology

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression

Maria R. Parkhurst et al.

CLINICAL CANCER RESEARCH (2011)

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Article Oncology

Activating Signals Dominate Inhibitory Signals in CD137L/IL-15 Activated Natural Killer Cells

Hua Zhang et al.

JOURNAL OF IMMUNOTHERAPY (2011)

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Article Medicine, General & Internal

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Antonio Di Stasi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia

David L. Porter et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Multidisciplinary Sciences

Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process

Jan Spanholtz et al.

PLOS ONE (2011)

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Article Hematology

Natural Killer Cell-Enriched Donor Lymphocyte Infusions from A 3-6/6 HLA Matched Family Member following Nonmyeloablative Allogeneic Stem Cell Transplantation

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2010)

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