期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 443, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2022.130248
关键词
OPFRs; E -waste dismantling; Dermal exposure; Thyroid hormone; Occupational exposure
This study evaluated the association between organophosphorus flame retardants (OPFRs) in handwipes and internal body burden on workers and residents in an e-waste dismantling area. The findings suggest that handwipes can serve as non-invasive exposure indicators to assess body burden and health effects of dermal exposure to OPFRs on thyroid hormones (THs).
Dermal exposure is increasingly recognized as an important pathway for organic pollutant exposure. However, data on dermal exposure are limited, particularly with respect to the health effects. This study evaluated association between organophosphorus flame retardants (OPFRs) in handwipes and internal body burden on workers and adult residents in an electronic waste (e-waste) dismantling area. The impact of dermal exposure to OPFRs on thyroid hormones (THs) served as a biomarker for early effects. Triphenyl phosphate (TPhP) was the most detected compound in handwipes, with median levels of 1180, 200, and 24.0 ng in people identified as e-waste bakers, e-waste dismantlers, and adult residents. Among e-waste dismantlers, TPhP levels in handwipes were positively correlated with paired serum TPhP and urinary diphenyl phosphate (DPhP) levels. In multiple linear regression models controlling for sex, age and smoking, TPhP levels in handwipes of e-waste dismantlers were significantly negatively correlated with three THs used to evaluate thyroid function: serum reverse 3,3 ',5-triiodoL-thyronine (rT3), 3,3 '-diiodo-L-thyronine (3,3 '-T2), and 3,5-diiodo-L-thyronine (3,5-T2). These findings suggest that handwipes can act as non-invasive exposure indicators to assess body burden of dermal exposure to TPhP and health effects on THs of e-waste dismantlers. This study highlights importance of OPFR effect on human THs through dermal exposure.
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