☆ 4.7 Review

SWOT analysis of noninvasive tests for diagnosing NAFLD with severe fibrosis: an expert review by the JANIT Forum

JOURNAL OF GASTROENTEROLOGY (2023)

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Article Gastroenterology & Hepatology

Poor Diagnostic Efficacy of Noninvasive Tests for Advanced Fibrosis in Obese or Younger Than 60 Diabetic NAFLD patients

Takanori Ito et al.

Summary: This study analyzed 1489 patients with NAFLD and found that FIB-4 had higher diagnostic efficacy for F3-4 fibrosis compared to NFS and HFS. However, this difference varied greatly by age, BMI, and T2DM, and all NITs including FIB-4 had unacceptably poor performance in young or obese diabetic patients.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Article Gastroenterology & Hepatology

Direct Comparison of US and MR Elastography for Staging Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Kento Imajo et al.

Summary: MRE, VCTE, and 2D-SWE all demonstrated excellent diagnostic accuracy in detecting liver fibrosis in patients with NAFLD. MRE showed the highest diagnostic accuracy for stage 4 detection and intra- and inter-observer reproducibility.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Endocrinology & Metabolism

Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease

Sami Qadri et al.

Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Letter Gastroenterology & Hepatology

An elevated FIB-4 score predicts liver cancer development: A longitudinal analysis from 29,999 patients with NAFLD

Sven H. Loosen et al.

JOURNAL OF HEPATOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

MRI-Based Quantitative R2*Mapping at 3 Tesla Reflects Hepatic Iron Overload and Pathogenesis in Nonalcoholic Fatty Liver Disease Patients

Kento Imajo et al.

Summary: This study investigated the impact of hepatic iron overload on nonalcoholic fatty liver disease and validated the diagnostic accuracy of MRI-based R2* quantification in evaluating hepatic iron content and pathological findings in NAFLD. The results indicated that R2* >= 62.5 s(-1) is a promising non-invasive diagnostic modality for clinically important high grades of HIB associated with increased HIC.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2022)

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Review Gastroenterology & Hepatology

Breakthroughs in therapies for NASH and remaining challenges

Vlad Ratziu et al.

Summary: Nonalcoholic steatohepatitis (NASH) has become a leading cause of chronic liver disease, and the need for effective treatments is urgent. Recent breakthroughs and progress in understanding the pathogenesis have set the stage for future therapeutic successes in NASH.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

The present and future of gastroenterology and hepatology: an international SWOT analysis (the GASTROSWOT project)

Enrique de-Madaria et al.

Summary: GASTROSWOT is a strategic analysis aiming to provide guidance for research, clinical, and financial planning in gastroenterology. The analysis reveals the increasing incidence and complexity of gastrointestinal diseases, the impact of the COVID-19 pandemic on patient care, and emphasizes the need for well-trained workforce and strategic planning in the field. The future of gastroenterology will be influenced by artificial intelligence and big data, which will accelerate discovery and smarter health-care provision. However, careful planning is crucial to balance the growth and diversification of gastroenterological specialties and the value of general gastroenterology services.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Medicine, General & Internal

Surgical and Anatomic Consideration in Endoscopic Dacryocystorhinostomy of a Patient with Damaged Sinonasal Anatomy Post-Caldwell-Luc Surgery: A Case Report

Chia-Chen Hsu et al.

Summary: This case report describes a patient who underwent a Caldwell-Luc procedure and developed epiphora as a complication. Preoperative CT imaging and nasal endoscopy showed sinonasal anomalies and difficulties in localizing the lacrimal sac. Endoscopic dacryocystorhinostomy was successfully performed with the aid of nasal forceps and transcanalicular illumination, resulting in complete resolution of symptoms and no recurrence.

MEDICINA-LITHUANIA (2022)

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Review Medicine, General & Internal

A meta-analysis on the diagnostic performance of magnetic resonance imaging and transient elastography in nonalcoholic fatty liver disease

Qing Gu et al.

Summary: This study compared the efficacy and accuracy of MRI and TE for assessing hepatic steatosis in NAFLD patients. The results showed that both MRI-PDFF and TE-CAP are highly accurate noninvasive methods for quantifying and staging hepatic steatosis in NAFLD. MRI-PDFF is significantly more accurate than TE-CAP for evaluating dichotomized grades of steatosis.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Gastroenterology & Hepatology

MRE combined with FIB-4 (MEFIB) index in detection of candidates for pharmacological treatment of NASH-related fibrosis

Jinho Jung et al.

Summary: The study demonstrated that the combination of MRE and FIB-4 showed high diagnostic accuracy in identifying patients with NAFLD who have stage 2 or higher fibrosis, making them suitable candidates for pharmacological therapy.

GUT (2021)

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Article Gastroenterology & Hepatology

A novel rapid immunoassay of serum type IV collagen 7S for the diagnosis of fibrosis stage of nonalcoholic fatty liver diseases

Toshihide Shima et al.

Summary: T4C7S chemiluminescent enzyme immunoassay (T4C7S CLEIA) showed a high correlation with T4C7S radioimmunoassay (T4C7S RIA) in serum samples of NAFLD patients. T4C7S CLEIA demonstrated higher sensitivity, faster measurement time, and showed promise as a popular biomarker for fibrosis stage diagnosis in NAFLD patients.

HEPATOLOGY RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein as a Screening Tool for Significant Liver Fibrosis in Health Checkup

Nobuharu Tamaki et al.

Summary: This study shows that WFA(+)-M2BP is associated with significant liver fibrosis and can be used to screen for fibrotic subjects in a large population.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Refining the Baveno VI elastography criteria for the definition of compensated advanced chronic liver disease

Margarita Papatheodoridi et al.

Summary: The study found that, compared to the dual cut-offs of <10 and >15 kPa proposed by Baveno VI, the dual cut-offs of <8 kPa (or <7 kPa for viral hepatitis) and >12 kPa have better diagnostic accuracy in cACLD.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

David Petroff et al.

Summary: This study conducted an individual patient data meta-analysis to evaluate the diagnostic properties of hepatic steatosis using CAP. Results showed that optimal cutoffs for CAP varied according to different etiologies of liver disease. While CAP may not adequately grade steatosis in patients with NAFLD, it can effectively identify significant steatosis in patients with viral hepatitis.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

Ramy Younes et al.

Summary: This study compared various non-invasive scoring systems in identifying risk and predicting long-term outcomes for patients with non-alcoholic fatty liver disease. NFS, HFS, and FIB-4 outperformed APRI and BARD in both cross-sectional identification of fibrosis and prediction of long-term outcomes, making them useful tools for clinical management of NAFLD patients at increased risk of fibrosis and liver-related complications or death.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH

Rohit Loomba et al.

Summary: In patients with bridging fibrosis and cirrhosis, 48 weeks of treatment with cilofexor/firsocostat was well tolerated and resulted in improvements in NASH activity, potentially having an antifibrotic effect. This combination offers potential for fibrosis regression with longer-term therapy in patients with advanced fibrosis attributable to NASH.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Artificial intelligence/neural network system for the screening of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Takeshi Okanoue et al.

Summary: The study aimed to develop a novel noninvasive test using an AI/NN system called NASH-Scope, which showed excellent sensitivity and specificity in distinguishing between NAFLD and NASH in training and validation studies.

HEPATOLOGY RESEARCH (2021)

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Article Gastroenterology & Hepatology

Artificial intelligence in prediction of non-alcoholic fatty liver disease and fibrosis

Grace Lai-Hung Wong et al.

Summary: The increasing use of AI in healthcare, particularly in the care of patients with chronic liver disease, has provided new insights for better patient care. Various AI approaches, such as logistic regression, decision tree, random forest, and XGBoost, have been utilized in applications such as liver biopsy and liver images to improve diagnostic accuracy and patient outcomes.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Computer Science, Information Systems

Development of a novel machine learning model to predict presence of nonalcoholic steatohepatitis

Matt Docherty et al.

Summary: The study developed a computer model using machine learning to predict patients with nonalcoholic steatohepatitis (NASH). With a combination of retrospective study and two databases, the model exhibited high performance in predicting NASH.

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION (2021)

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Review Gastroenterology & Hepatology

Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology

Chrysanthos D. Christou et al.

Summary: Artificial intelligence (AI) and machine learning (ML) have broad applications in medicine, particularly in gastroenterology and hepatology, aiding in prevention, diagnosis, management, and prognosis. However, the application of AI in healthcare is faced with challenges such as intrinsic biases, data protection, and ethical concerns.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

Emmanuel Anandraj Selvaraj et al.

Summary: Non-invasive tests measuring liver stiffness or using MRI have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these tests cannot be fully assessed due to lack of intention-to-diagnose analyses and validation of pre-specified thresholds.

JOURNAL OF HEPATOLOGY (2021)

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Article Medical Laboratory Technology

Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases

Se Young Jang et al.

Summary: The study evaluated the diagnostic efficacy of M2BPGi compared with other liver fibrosis markers in non-alcoholic fatty liver disease (NAFLD). Results showed that M2BPGi may be a good biomarker for diagnosing advanced fibrosis and cirrhosis in NAFLD patients.

ANNALS OF LABORATORY MEDICINE (2021)

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Article Gastroenterology & Hepatology

Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator (SPPARM alpha), versus placebo in patients with non-alcoholic fatty liver disease

Atsushi Nakajima et al.

Summary: In patients with high-risk non-alcoholic fatty liver disease, Pemafibrate did not reduce liver fat content but significantly decreased liver stiffness based on magnetic resonance elastography. There was also a significant reduction in ALT and LDL-C levels during the treatment period.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

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Article Gastroenterology & Hepatology

Predictive value of cytokeratin-18 fragment levels for diagnosing steatohepatitis in patients with nonalcoholic fatty liver disease

Toshifumi Tada et al.

Summary: This study investigated the predictive value of CK18-F level and FIB-4 index for diagnosing NASH in NAFLD patients. The CK18-F level showed good predictive ability for diagnosing NASH, and the combination of CK18-F level and FIB-4 index accurately and noninvasively predicted NASH.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Comparison and development of advanced machine learning tools to predict nonalcoholic fatty liver disease: An extended study

Yuan-Xing Liu et al.

Summary: A total of seven predictive models for NAFLD were developed and validated using machine learning algorithms, with the XGBoost model showing the best performance. Body mass index was identified as the most valuable indicator for predicting NAFLD. The use of machine learning tools has significant potential in NAFLD screening.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2021)

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Article Gastroenterology & Hepatology

Novel artificial intelligent/neural network system for staging of nonalcoholic steatohepatitis

Takeshi Okanoue et al.

Summary: The novel noninvasive test using the AI/NN system Fibro-Scope accurately determines fibrosis stage in NASH, with high sensitivity and specificity in differentiation between different stages. This will facilitate rapid diagnosis of NASH and improve identification of fibrosis stage.

HEPATOLOGY RESEARCH (2021)

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Article Gastroenterology & Hepatology

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020

Katsutoshi Tokushige et al.

Summary: NAFLD and NASH have become significant public health issues in both Western countries and Japan, with hepatic fibrosis being a key prognostic factor. Effective screening methods for NAFLD and urgent surveillance for HCC are necessary in Japan, where non-viral liver disease-related HCC cases are on the rise. Cardiovascular disease is the leading cause of death in NAFLD patients, emphasizing the importance of CVD monitoring in clinical practice. Several drug trials are ongoing for NAFLD/NASH therapy, with new treatments like SGLT2 inhibitors and GLP-1 analogues showing promise for future interventions.

HEPATOLOGY RESEARCH (2021)

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Review Gastroenterology & Hepatology

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020

Katsutoshi Tokushige et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a serious public health issue in Japan, with nonalcoholic steatohepatitis (NASH) being a progressive form that can lead to liver cirrhosis and increase the risk of hepatocellular carcinoma. The most common cause of death in NAFLD patients is cardiovascular disease.

JOURNAL OF GASTROENTEROLOGY (2021)

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Article Acoustics

IMPROVED ULTRASOUND ATTENUATION MEASUREMENT METHOD FOR THE NON-INVASIVE EVALUATION OF HEPATIC STEATOSIS USING FIBROSCAN

Stephane Audiere et al.

Summary: The study evaluated a new CAP method for assessing liver steatosis, showing improved precision ex vivo and in vivo. The new method utilizes continuous ultrasound data during imaging phase, leading to better agreement and correlation with MRI-PDFF. The diagnostic performance of the new method was found to be equal or superior to the standard method.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Review Gastroenterology & Hepatology

Application of artificial intelligence in non-alcoholic fatty liver disease and liver fibrosis: a systematic review and meta-analysis

Pakanat Decharatanachart et al.

Summary: Artificial intelligence (AI)-supported systems show promising performance improvements in diagnosing non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and identifying liver fibrosis in NAFLD patients. AI-assisted ultrasonography performs better for diagnosing NAFLD compared to AI-assisted clinical data sets, with excellent sensitivity and specificity.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Case-finding strategies in non-alcoholic fatty liver disease

Jerome Boursier et al.

Summary: Diagnosing and managing non-alcoholic fatty liver disease (NAFLD) patients remains challenging, highlighting the importance of strengthening non-invasive detection methods for early diagnosis and improved treatment outcomes. The active participation of general practitioners and physicians managing metabolic disorders is crucial in addressing the issue of evaluating a large number of patients.

JHEP REPORTS (2021)

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Article Endocrinology & Metabolism

Addition of hyaluronic acid to the FIB-4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in type 2 diabetes: The Edinburgh Type 2 Diabetes Study

Sheila M. Grecian et al.

Summary: Adding hyaluronic acid to the FIB-4 index in individuals with T2D reduced the proportion of people incorrectly identified as high risk for developing cirrhosis/HCC, indicating the potential for improved risk assessment in this population.

OBESITY SCIENCE & PRACTICE (2021)

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Article Gastroenterology & Hepatology

Improvements of Fibrosis and Disease Activity Are Associated With Improvement of Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis

Zobair M. Younossi et al.

Summary: The study investigated the impact of investigational drugs on Patient-reported outcomes (PROs) of patients with advanced NASH. Patients with cirrhosis had lower baseline PRO scores, which were associated with age, female sex, higher BMI, diabetes, and comorbidities. Patients with fibrosis improvement or NAS score decrease experienced improvements in PROs, while progression to cirrhosis was associated with decreased scores in some PRO domains.

HEPATOLOGY COMMUNICATIONS (2021)

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Article Gastroenterology & Hepatology

Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes

Hiroshi Ishiba et al.

Summary: In patients with or without diabetes who have NAFLD, COL4-7S may be the best NIT for identifying advanced fibrosis.

HEPATOLOGY COMMUNICATIONS (2021)

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Article Gastroenterology & Hepatology

Development and Validation of Hepamet Fibrosis Scoring System-A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis

Javier Ampuero et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Performance of noninvasive scores for the diagnosis of advanced liver fibrosis in morbidly obese with nonalcoholic fatty liver disease

Maria A. L. de Carli et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

A novel spleen-dedicated stiffness measurement by FibroScan® improves the screening of high-risk oesophageal varices

Horia Stefanescu et al.

LIVER INTERNATIONAL (2020)

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Article Gastroenterology & Hepatology

Profiles of advanced hepatic fibrosis evaluated by FIB-4 index and shear wave elastography in health checkup examinees

Sakura Yamamura et al.

HEPATOLOGY RESEARCH (2020)

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Article Gastroenterology & Hepatology

Accuracy of liver stiffness measurement and controlled attenuation parameter using FibroScan® M/XL probes to diagnose liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease: a multicenter prospective study

Satoshi Oeda et al.

JOURNAL OF GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease and Fibrosis Associated With Increased Risk of Cardiovascular Events in a Prospective Study

Francesco Baratta et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Synbiotic Alters Fecal Microbiomes, but not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Non-alcoholic Fatty Liver Disease

Eleonora Scorletti et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Advances in non-invasive assessment of hepatic fibrosis

Rohit Loomba et al.

GUT (2020)

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Article Gastroenterology & Hepatology

Cilofexor, a NonsteroidalFXRAgonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial

Keyur Patel et al.

HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Accuracy of the Enhanced Liver Fibrosis test, and combination of the Enhanced Liver Fibrosis and non-invasive tests for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease

Chika Inadomi et al.

HEPATOLOGY RESEARCH (2020)

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Review Multidisciplinary Sciences

The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis

Yuanqiang Lin et al.

PLOS ONE (2020)

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Article Medicine, General & Internal

Impact of the Fibrosis-4 Index on Risk Stratification of Cardiovascular Events and Mortality in Patients with Atrial Fibrillation: Findings from a Japanese Multicenter Registry

Yuki Saito et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Gastroenterology & Hepatology

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

Philip N. Newsome et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Medicine, General & Internal

Camptocormia as a Novel Phenotype in a Heterozygous POLG2 Mutation

Diana Lehmann Urban et al.

DIAGNOSTICS (2020)

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Article Gastroenterology & Hepatology

Diagnostic accuracy of FibroScan-AST score to identify non-alcoholic steatohepatitis with significant activity and fibrosis in Japanese patients with non-alcoholic fatty liver disease: Comparison between M and XL probes

Satoshi Oeda et al.

HEPATOLOGY RESEARCH (2020)

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Article Acoustics

Comparative study between pSWE and 2D-SWE techniques integrated in the same ultrasound machine, with Transient Elastography as the reference method

Camelia Foncea et al.

MEDICAL ULTRASONOGRAPHY (2020)

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Article Medicine, General & Internal

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Naeimeh Atabaki-Pasdar et al.

PLOS MEDICINE (2020)

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Article Gastroenterology & Hepatology

Expanding the use of the vibration controlled transient elastography in morbid obese patients: validation of a new automated adaptive measurement depths algorithm in a large pooled NAFLD cohort

Philip N Newsome et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

MAFLD identifies patients with significant hepatic fibrosis better than NAFLD

Sakura Yamamura et al.

LIVER INTERNATIONAL (2020)

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Review Multidisciplinary Sciences

Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis

Jenny Lee et al.

PLOS ONE (2020)

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Article Gastroenterology & Hepatology

Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease

Mohammad S. Siddiqui et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants

Cynthia Hsu et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis

Samuel J. Daniels et al.

HEPATOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Liver Stiffness Reflecting Right-Sided Filling Pressure Can Predict Adverse Outcomes in Patients With Heart Failure

Tatsunori Taniguchi et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Gastroenterology & Hepatology

Non-invasive fibrosis scoring systems can predict future metabolic complications and overall mortality in non-alcoholic fatty liver disease (NAFLD)

Kristina Onnerhag et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2019)

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Review Gastroenterology & Hepatology

Noninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice

Jiang-Hua Zhou et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease

Yasushi Honda et al.

HEPATOLOGY RESEARCH (2019)

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Article Gastroenterology & Hepatology

Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification

George N. Ioannou et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Cost-comparison analysis of FIB-4, ELF and fibroscan in community pathways for non-alcoholic fatty liver disease

Ankur Srivastava et al.

BMC GASTROENTEROLOGY (2019)

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Transient liver elastography in normal pregnancy - a longitudinal cohort study

Marcus Stenberg Ribeiro et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2019)

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Wisteria floribunda agglutinin-positive mac-2 binding protein as an age-independent fibrosis marker in nonalcoholic fatty liver disease

Nobuharu Tamaki et al.

SCIENTIFIC REPORTS (2019)

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Multicenter Validation Study of a Diagnostic Algorithm to Detect NASH and Fibrosis in NAFLD Patients With Low NAFLD Fibrosis Score or Liver Stiffness

Stephanie Liebig et al.

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Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis

Rohit Loomba et al.

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Accuracy of Noninvasive Scoring Systems in Assessing Risk of Death and Liver-Related Endpoints in Patients With Nonalcoholic Fatty Liver Disease

Hannes Hagstrom et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Unified interpretation of liver stiffness measurement by M and XL probes in non-alcoholic fatty liver disease

Vincent Wai-Sun Wong et al.

GUT (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Magnetic Resonance Elastography in Primary Sclerosing Cholangitis: Interobserver Agreement for Liver Stiffness Measurement with Manual and Automated Methods

Safa Hoodeshenas et al.

ACADEMIC RADIOLOGY (2019)

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Article Gastroenterology & Hepatology

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

Naga Chalasani et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

Chris Estes et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis

Eva Herrmann et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Steatosis severity affects the diagnostic performances of noninvasive fibrosis tests in nonalcoholic fatty liver disease

Sae Kyung Joo et al.

LIVER INTERNATIONAL (2018)

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Article Biotechnology & Applied Microbiology

New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease

Toshifumi Tada et al.

BIOMARKERS (2018)

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Article Gastroenterology & Hepatology

Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration

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DIGESTIVE DISEASES AND SCIENCES (2018)

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Article Gastroenterology & Hepatology

The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study

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JOURNAL OF GASTROENTEROLOGY (2018)

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Review Gastroenterology & Hepatology

Pharmacotherapy for NASH: Current and emerging

Monica A. Konerman et al.

JOURNAL OF HEPATOLOGY (2018)

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A combined model based on spleen stiffness measurement and Baveno VI criteria to rule out high-risk varices in advanced chronic liver disease

Antonio Colecchia et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease

Naoyuki Fujimori et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Multidisciplinary Sciences

Noninvasive scoring systems predict hepatic and extra-hepatic cancers in patients with nonalcoholic fatty liver disease

Noam Peleg et al.

PLOS ONE (2018)

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Article Gastroenterology & Hepatology

Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patient, with Nonalcoholic Liver Disease

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

Fasiha Kanwal et al.

GASTROENTEROLOGY (2018)

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Article Gastroenterology & Hepatology

Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia

Franziska J. Ammon et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Biotechnology & Applied Microbiology

Application of Machine Learning Techniques for Clinical Predictive Modeling: A Cross-Sectional Study on Nonalcoholic Fatty Liver Disease in China

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BIOMED RESEARCH INTERNATIONAL (2018)

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Article Gastroenterology & Hepatology

Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis

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AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

Improved Noninvasive Prediction of Liver Fibrosis by Liver Stiffness Measurement in Patients With Nonalcoholic Fatty Liver Disease Accounting for Controlled Attenuation Parameter Values

Salvatore Petta et al.

HEPATOLOGY (2017)

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Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

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HEPATOLOGY INTERNATIONAL (2017)

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Article Surgery

Modified thresholds for fibrosis risk scores in nonalcoholic fatty liver disease are necessary in the obese

Geraldine J. Ooi et al.

OBESITY SURGERY (2017)

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Comparison of Laboratory Tests, Ultrasound, or Magnetic Resonance Elastography to Detect Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: A Meta-Analysis

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HEPATOLOGY (2017)

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Review Gastroenterology & Hepatology

Increased Risk of Mortality by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

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HEPATOLOGY (2017)

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Artificial intelligence in healthcare: past, present and future

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STROKE AND VASCULAR NEUROLOGY (2017)

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Article Gastroenterology & Hepatology

Ability of Cytokeratin-18 Fragments and FIB-4 Index to Diagnose Overall and Mild Fibrosis Nonalcoholic Steatohepatitis in Japanese Nonalcoholic Fatty Liver Disease Patients

Natsuko Kobayashi et al.

DIGESTIVE DISEASES (2017)

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Article Gastroenterology & Hepatology

AST to Platelet Ratio Index and fibrosis 4 calculator scores for non-invasive assessment of hepatic fibrosis in patients with non-alcoholic fatty liver disease

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DIGESTIVE AND LIVER DISEASE (2017)

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Review Gastroenterology & Hepatology

Transient elastography versus hepatic venous pressure gradient for diagnosing portal hypertension: a systematic review and meta-analysis

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CLINICAL AND MOLECULAR HEPATOLOGY (2017)

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Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography

Kento Imajo et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

Anita Kiani et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Learning curve and intra/interobserver agreement of transient elastography in chronic hepatitis C patients with or without HIV co-infection

Hugo Perazzo et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2016)

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Editorial Material Medicine, General & Internal

GUIDELINES Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance

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BMJ-BRITISH MEDICAL JOURNAL (2016)

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Editorial Material Medicine, General & Internal

GUIDELINES Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance

Jessica Glen et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Editorial Material Gastroenterology & Hepatology

Huge Adrenal Hemangioma: A Rare Cause of Deceivingly High Liver Stiffness Measurement by Transient Elastography

Grace Lai-Hung Wong et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2015)

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Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Sumio Watanabe et al.

HEPATOLOGY RESEARCH (2015)

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Article Gastroenterology & Hepatology

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Sumio Watanabe et al.

JOURNAL OF GASTROENTEROLOGY (2015)

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Article Gastroenterology & Hepatology

Magnetic Resonance Elastography Predicts Advanced Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Study

Rohit Loomba et al.

HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Serum cytokeratin-18 in the diagnosis of non-alcoholic steatohepatitis: A meta-analysis

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HEPATOLOGY RESEARCH (2014)

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Article Gastroenterology & Hepatology

Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease

Kenneth Cusi et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Multidisciplinary Sciences

The Frequency and Determinants of Liver Stiffness Measurement Failure: A Retrospective Study of Real-Life'' 38,464 Examinations

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PLOS ONE (2014)

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Review Gastroenterology & Hepatology

Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Yoshio Sumida et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Simple Noninvasive Systems Predict Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

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GASTROENTEROLOGY (2013)

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Review Radiology, Nuclear Medicine & Medical Imaging

Magnetic resonance elastography of liver: Technique, analysis, and clinical applications

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JOURNAL OF MAGNETIC RESONANCE IMAGING (2013)

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A serum sweet-doughnut protein facilitates fibrosis evaluation and therapy assessment in patients with viral hepatitis

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SCIENTIFIC REPORTS (2013)

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Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2012)

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Article Gastroenterology & Hepatology

Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population

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BMC GASTROENTEROLOGY (2012)

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Non-invasive detection of hepatic amyloidosis: FibroScan, a new tool

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AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2011)

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Article Medicine, General & Internal

Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity

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ANNALS OF MEDICINE (2011)

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Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2009)

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Article Gastroenterology & Hepatology

Cytokeratin-18 Fragment Levels as Noninvasive Biomarkers for Nonalcoholic Steatohepatitis: A Multicenter Validation Study

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HEPATOLOGY (2009)

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The HCV serum proteome: a search for fibrosis protein markers

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JOURNAL OF VIRAL HEPATITIS (2009)

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Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD)

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DIGESTIVE AND LIVER DISEASE (2008)

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Article Gastroenterology & Hepatology

Extrahepatic Cholestasis Increases Liver Stiffness (FibroScan) Irrespective of Fibrosis

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HEPATOLOGY (2008)

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Multiecho reconstruction for simultaneous water-fat decomposition and T2*estimation

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Identification of proteins bearing β1-6 branched N-glycans in human melanoma cell lines from different progression stages by tandem mass spectrometry analysis

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)

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The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD

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HEPATOLOGY (2007)

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In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

Anna Wieckowska et al.

HEPATOLOGY (2006)

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Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection

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HEPATOLOGY (2006)

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Sampling variability of liver biopsy in nonalcoholic fatty liver disease

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GASTROENTEROLOGY (2005)

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A SWOT analysis of the field of virtual reality rehabilitation and therapy

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PRESENCE-TELEOPERATORS AND VIRTUAL ENVIRONMENTS (2005)

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Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis

AE Feldstein et al.

GASTROENTEROLOGY (2003)

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Transient elastography: A new noninvasive method for assessment of hepatic fibrosis

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ULTRASOUND IN MEDICINE AND BIOLOGY (2003)

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90K (Mac-2 BP) and galectins in tumor progression and metastasis

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GLYCOCONJUGATE JOURNAL (2002)

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