Mesua assamica (King&Prain) kosterm. Bark ethanolic extract attenuates chronic restraint stress aggravated DSS-induced ulcerative colitis in mice via inhibition of NF-&UKAPPA;B/STAT3 and activation of HO-1/Nrf2/SIRT1 signaling pathways

Article Immunology

Perillyl alcohol inhibits keratinocyte proliferation and attenuates imiquimod-induced psoriasis like skin-inflammation by modulating NF-?B and STAT3 signaling pathways

Md. Abubakar et al.

Summary: Perillyl alcohol (POH) exhibits potential therapeutic effects on psoriasis by reducing inflammation and proliferative markers, showing significant results in vitro and in animal models.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Materials Science, Biomaterials

Multifunctional Polymeric Nanoparticles for Chemo/Phototheranostics of Retinoblastoma

Sushma Venkata Mudigunda et al.

Summary: Retinoblastoma is a critical intraocular malignancy in children, and chemo/photothermal therapy with multifunctional polymeric nanoparticles (PNPs) entrapped with anticancer drug and near-infrared dye showed significant cytotoxic effect on retinoblastoma cells. In vivo studies in a mice model demonstrated optimal photoacoustic signals, suggesting the potential of this combined approach for retinoblastoma therapy.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

添加到收藏夹

Article Plant Sciences

Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models

Eswara Rao Puppala et al.

Summary: This study aimed to evaluate the anti-inflammatory effects of perillyl alcohol (POH) on rheumatoid arthritis. The results demonstrated that POH suppressed inflammation and oxidative stress through regulating signaling pathways in both in vitro and in vivo experiments. These findings suggest the potential therapeutic effects of POH in rheumatoid arthritis.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Plant Sciences

Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4/NF-κB and JAK2/STAT3 signaling pathways

Eswara Rao Puppala et al.

Summary: This study explored the anti-ulcerative properties of perillyl alcohol (POH) on stress aggravated ulcerative colitis. The results showed that POH reversed oxidative stress and inflammatory response by inhibiting TLR4/NF-kB pathway and IL-6/JAK2/STAT3 pathway, leading to a decrease in pro-inflammatory cytokines. It also improved the physiological and histological changes of ulcerative colitis, and increased the mobility time and neurotransmitters while decreasing cortisol in mice brains.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota

Li Cui et al.

Summary: SP2-1 polysaccharide from Scutellaria baicalensis Georgi shows protective effects against ulcerative colitis by improving pathological damage, reducing weight loss, and repairing intestinal barrier. Additionally, it significantly increases beneficial bacteria and inhibits the growth of harmful bacteria.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

A novel bioavailable curcumin-galactomannan complex modulates the genes responsible for the development of chronic diseases in mice: A RNA sequence analysis

Kishore Banik et al.

Summary: The novel curcumagalactomannosides (CGM) have shown higher bioavailability than traditional curcumin, indicating potential for prevention and treatment of chronic diseases. The study revealed significant effects of CGM on the expression of various genes in liver tissues, suggesting its therapeutic benefits for multiple chronic diseases.

LIFE SCIENCES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Geometry encoded functional programming of tumor homing peptides for targeted drug delivery

Ruchika Goyal et al.

Summary: The research demonstrates that designed and optimized peptides have different uptake abilities in various cancer cells and can penetrate tumorospheres. The cytotoxic effects of these peptides were confirmed to be apoptotic by observing mitochondrial membrane potential depolarization and Caspase-3 activation. Additionally, in vivo and clinical samples studies further confirmed the peptides' ability to selectively recognize tumor cells.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Review Microbiology

Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes

Van A. Ortega et al.

Summary: This article discusses the biological and neuroendocrine networks regulating stress response, as well as the impact of gut microbiota on early-life development that may predispose individuals to various diseases later in life. Animal models have confirmed the influence of gut microbiota on HPA axis activity, stress reactivity, and brain development.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach

Kalyani Tene et al.

Summary: The extract of DP showed strong antioxidant potential in combating Dox-induced cardiotoxicity, protecting cardiomyocytes and reducing ROS levels, which could be attributed to polyphenolic antioxidant compounds present in DP such as gallic acid, syringic acid, and sinapic acid.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Lithocholic acid-tryptophan conjugate (UniPR126) based mixed micelle as a nano carrier for specific delivery of niclosamide to prostate cancer via EphA2 receptor

Arun Kumar Jannu et al.

Summary: Targeted delivery of chemotherapeutic agent through EphA2 receptor using UniPR126 as a carrier in mixed nanomicellar system showed significant enhancement in uptake by cancer cells and resulted in synergistic cytotoxicity. In vivo data also revealed a reduction in tumor volume with niclosamide-loaded nanomicelle compared to pure niclosamide, indicating improved anticancer efficacy through interference with EphA2 receptor signaling and inhibition of the Wnt/beta-catenin pathway.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology