Iso-seco-tanapartholide from Artemisia argyi inhibits the PFKFB3-mediated glycolytic pathway to attenuate airway inflammation in lipopolysaccharide-induced acute lung injury mice

Article Immunology

The PPAR-γ agonist pioglitazone exerts proinflammatory effects in bronchial epithelial cells during acute Pseudomonas aeruginosa pneumonia

Bianca L. Ferreira et al.

Summary: During acute P. aeruginosa pneumonia, the PPAR-gamma agonist pioglitazone exerts a selective proinflammatory effect on bronchial epithelial cells, possibly by enhancing intracellular glycolysis.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2022)

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Article Medicine, Research & Experimental

The role of macrophage-fibroblast interaction in lipopolysaccharide-induced pulmonary fibrosis: an acceleration in lung fibroblast aerobic glycolysis

Qiaoyi Xu et al.

Summary: The study demonstrates that lipopolysaccharide induces activation of the JNK signaling pathway and TNF-alpha secretion in pulmonary macrophages, leading to interaction between inflammation and metabolism that promotes lung fibroblast glycolysis. This interaction plays a crucial role in lipopolysaccharide-induced pulmonary fibrosis.

LABORATORY INVESTIGATION (2022)

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Article Cell Biology

IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis

Chengcheng Song et al.

Summary: Renal inflammation is a critical characteristic of diabetic kidney disease (DKD), but effective treatments are limited. This study found that insulin-like growth factor-binding protein 5 (IGFBP5) is significantly increased in the kidneys of diabetic mice. Elimination of IGFBP5 alleviated kidney inflammation in DKD mice. Mechanistically, IGFBP5 increased glycolysis in endothelial cells through the activation of the transcription factor EGR1 and enhanced expression of PFKFB3, which in turn enhanced renal inflammation.

CELL DEATH & DISEASE (2022)

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Article Crystallography

Investigation of Major Flavonoids from Artemisia argyi as a Potential COVID-19 Drug: Molecular Docking and DFT Calculations

Yang Lu et al.

Summary: Flavonoids from Artemisia argyi show high binding affinity to the main protease of SARS-CoV-2, indicating their potential as antiviral agents against COVID-19. The computational analysis suggests that these flavonoids could serve as inhibitors for SARS-CoV-2, with compound (5) exhibiting the strongest binding affinity.

CRYSTALS (2022)

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Article Immunology

The inhibition of GLUT1-induced glycolysis in macrophage by phloretin participates in the protection during acute lung injury

Yiyan Songyang et al.

Summary: This study found that phloretin (PHL), an apple polyphenol, can prevent lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting glycolysis in macrophages, and its action depends on the inhibition of glucose transporter 1 (GLUT1).

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Biochemical Research Methods

Pathogenetic profiling of COVID-19 and SARS-like viruses

Zulkar Nain et al.

Summary: This study revealed genetic linkage between 2019-nCoV and SARS-CoV through whole-genome alignment and gene expression analysis, identified shared genes related to COVID-19 complications, and suggested potential drug candidates for combating COVID-19 based on protein-chemical interactions.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Pharmacology & Pharmacy

Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension

Lina Wang et al.

Summary: The study demonstrates that the reduced expression of glycolytic molecules in lung macrophages due to Pfkfb3 deficiency or inhibition can effectively alleviate the development of pulmonary hypertension, with lower levels of growth factors and pro-inflammatory cytokines produced by alveolar macrophages.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Plant Sciences

From longevity grass to contemporary soft gold: Explore the chemical constituents, pharmacology, and toxicology of Artemisia argyi H.Lev. & vaniot essential oil

Yu Liu et al.

Summary: Artemisia argyi, known as the longevity grass in eastern countries, has been used for over two thousand years for its warm effect in curing cold diseases. The Artemisia argyi essential oil has been recognized for its medicinal properties and developed into various health products, showing potential in disease resistance, anti-inflammatory, analgesic, and anti-cancer effects. The plant has demonstrated remarkable efficacy in traditional medicine, but further research is needed to fully understand its toxicity and mechanism of action.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Developmental Biology

PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8/Svneo cells: Implications for the role of PFKFB3 in preeclampsia

Yang Zhang et al.

Summary: PFKFB3 is up-regulated in preeclamptic placenta and controls LPS-induced inflammation via the NF-kappa B pathway, impacting trophoblasts function such as adhesion, oxidative stress, apoptosis, migration, and invasion.

PLACENTA (2021)

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Article Immunology

Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways

Zhen-Hua Ying et al.

Summary: IRD exerts protective effects against LPS-induced inflammation by suppressing the PKM2-mediated pathway, reducing inflammatory cytokine release, and alleviating oxidative stress, as demonstrated in both murine macrophage and mouse models.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia

Jiean Xu et al.

Summary: The study reveals the critical role of Pfkfb3 in LPS-induced sepsis, showing that its knockout protects mice from severe effects and reduces inflammation by regulating the expression of inflammatory factors.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Biochemical Research Methods

Pharmacokinetic and tissue distribution study of eight volatile constituents in rats orally administrated with the essential oil of Artemisiae argyi Folium by GC-MS/MS

Ming-Zhu Hou et al.

Summary: Artemisia argyi is used in traditional Chinese medicine to treat gynecological and respiratory diseases, with its essential oil considered as the major active ingredients. A study developed a rapid, sensitive, and selective method for quantifying the distribution of these volatile constituents in rat plasma and tissues. The results provide insight for guiding pharmacodynamic studies and clinical applications of this herbal medicine.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)

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Article Gastroenterology & Hepatology

Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3

Linqiang Ma et al.

HEPATOLOGY (2020)

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Editorial Material Cell & Tissue Engineering

Mesenchymal stem cells as a potential therapy for COVID-19

Shan Liu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Pharmacology & Pharmacy

Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds

Amy M. Zimmermann-Klemd et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Protective Effect of Colchicine on LPS-Induced Lung Injury in Rats via Inhibition of P-38, ERK1/2, and JNK Activation

Qianyu Yue et al.

PHARMACOLOGY (2020)

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Review Chemistry, Medicinal

PFKFB3 inhibitors as potential anticancer agents: Mechanisms of action, current developments, and structure-activity relationships

Yinhu Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Immunology

Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway

Haihua Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis

Prince Baffour Tonto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Pharmacology & Pharmacy

Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathway

Jinyan Ye et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2019)

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Article Biochemistry & Molecular Biology

Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - A divergent role for glycolysis

Vijith Vijayan et al.

REDOX BIOLOGY (2019)

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Article Multidisciplinary Sciences

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Yapeng Cao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Editorial Material Endocrinology & Metabolism

Antagonism between Antiviral Signaling and Glycolysis

Anoop Singh Chauhan et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

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Article Pharmacology & Pharmacy

Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

Lina Wang et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Chemistry, Medicinal

Lactone ring-opening seco-guaianolide involved heterodimers linked via an ester bond from Artemisia argyi with NO inhibitory activity

Gui-Min Xue et al.

FITOTERAPIA (2019)

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Article Critical Care Medicine

PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension

Laszlo Kovacs et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Multidisciplinary Sciences

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages

Orla M. Finucane et al.

SCIENTIFIC REPORTS (2019)

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Review Pharmacology & Pharmacy

The potential utility of PFKFB3 as a therapeutic target

Ramon Bartrons et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2018)

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Review Medicine, General & Internal

Acute Respiratory Distress Syndrome Advances in Diagnosis and Treatment

Eddy Fan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Article Plant Sciences

Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals

Na-Rae Shin et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

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Article Oncology

Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

Hui-Min Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Article Chemistry, Analytical

Impact of chemotherapy on metabolic reprogramming: Characterization of the metabolic profile of breast cancer MDA-MB-231 cells using 1H HR-MAS NMR spectroscopy

Roberta M. Maria et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2017)

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Review Biochemistry & Molecular Biology

Current Concepts of ARDS: A Narrative Review

Michele Umbrello et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells

Yuanqi Gong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Review Medicine, Research & Experimental

A past and present overview of macrophage metabolism and functional outcomes

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CLINICAL SCIENCE (2017)

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Article Pharmacology & Pharmacy

Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis

Yaoyao Zou et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Article Medical Laboratory Technology

Acute Lung Injury A Clinical and Molecular Review

Yasmeen Butt et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2016)

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Article Multidisciplinary Sciences

Glucose and Palmitate Differentially Regulate PFKFB3/iPFK2 and Inflammatory Responses in Mouse Intestinal Epithelial Cells

Rachel Botchlett et al.

SCIENTIFIC REPORTS (2016)

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Article Hematology

HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages

Ahmed Tawakol et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Article Chemistry, Applied

Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi

Xiaoli Bao et al.

CARBOHYDRATE POLYMERS (2013)

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Review Immunology

Metabolic Pathways in Immune Cell Activation and Quiescence

Erika L. Pearce et al.

IMMUNITY (2013)

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Iso-seco-tanapartholide from Artemisia argyi inhibits the PFKFB3-mediated glycolytic pathway to attenuate airway inflammation in lipopolysaccharide-induced acute lung injury mice

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