期刊
JOURNAL OF EPIDEMIOLOGY
卷 32, 期 12, 页码 S104-S114出版社
JAPAN EPIDEMIOLOGICAL ASSOC
DOI: 10.2188/jea.JE20210252
关键词
nuclear accident; radiation dose; maternal exposure; pregnancy; perinatal outcomes
资金
- national Health Fund for Children and Adults Affected by the Nuclear Incident
This study investigated the effects of maternal exposure to external radiation on perinatal outcomes during the Fukushima Daiichi Nuclear Disaster (FDND) and found that external radiation dose was not associated with congenital anomalies, low birth weight, small for gestational age, or preterm birth.
Background: This study aimed to investigate the effects of maternal exposure to external radiation on perinatal outcomes among women who experienced the Fukushima Daiichi Nuclear Disaster (FDND) using the Fukushima Health Management Survey (FHMS).Methods: Data from the Pregnancy and Birth Survey and Basic Survey in the FHMS were combined to analyze external maternal radiation exposure following the FDND, and the relationship between radiation dose and perinatal outcomes was analyzed using binomial logistic regression analysis. Missing dose data were supplemented using multiple imputation.Results: A total of 6,875 individuals responded to the survey. Congenital anomalies occurred in 2.9% of patients, low birth weight (LBW) in 7.6%, small for gestation age (SGA; <10th percentile) in 8.9%, and preterm birth in 4.1%. The median maternal external radiation dose was 0.5 mSv (maximum, 5.2 mSv). Doses were classified as follows: <1 mSv (reference), 1 to <2 mSv, and >= 2 mSv. For congenital anomalies, the crude odds ratio for 1 to <2 mSv was 0.81 (95% confidence interval [CI], 0.56-1.17) (no participants with congenital anomaly were exposed to >= 2 mSv). At 1 to <2 mSv and >= 2 mSv, the respective adjusted odds ratios were 0.91 (95% CI, 0.71-1.18) and 1.21 (95% CI, 0.53-2.79) for LBW, 1.14 (95% CI, 0.92-1.42) and 0.84 (95% CI, 0.30-2.37) for SGA, and 0.91 (95% CI, 0.65-1.29) and 1.05 (95% CI, 0.22-4.87) for preterm birth.Conclusion: External radiation dose due to the FDND was not associated with congenital anomalies, LBW, SGA, or preterm birth.
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