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Nanoliposomes for doxorubicin delivery: Reversing drug resistance, stimuli-responsive carriers and clinical translation

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Marziyeh Salehiabar et al.

Summary: This article introduces a novel bimetallic nanoparticle-based multifunctional nanoplatform that acts as an effective radiosensitizer and enhances treatment efficacy by combining chemotherapy and radiotherapy. By encapsulating CUR into CuFe2O4 nanoparticles modified by BSA and FA, tumor accumulation is increased and adverse effects are reduced. The nanoplatform exhibits excellent biosafety, tumor-killing ability, and radiosensitizing capacity in vitro, as well as high cancer suppression efficiency in vivo. The co-administration of CuFe2O4@BSA-FA-CUR nanoparticles with X-ray radiation leads to complete tumor ablation in treated mice without any mortality or radiation-induced normal tissue toxicity, highlighting their biosafety and potential for radiosensitization of malignant tumors.

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Review Biotechnology & Applied Microbiology

Biomimetic cell membrane-coated poly(lactic-co-glycolic acid) nanoparticles for biomedical applications

Nasrullah Jan et al.

Summary: This article discusses the preparation methods and applications of cell membrane-coated PLGA nanoparticles, as well as their role in cancer therapy, inflammation management, cardiovascular disease treatment, and infection control. It also highlights the challenges and future research directions of cell membrane-camouflaged nanoparticles.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

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Review Oncology

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds

Zhaowu Ma et al.

Summary: Rapid progress in molecular cancer biology and the discovery of new oncology drugs have opened new opportunities for cancer target discovery. HIF-1, a crucial signaling pathway related to tumorigenesis, regulates the activity of many transcription factors and downstream molecules that affect tumor growth and metastasis. Overexpression of HIF-1 alpha is strongly associated with poor prognosis in several solid cancers. Pharmacological targeting of the HIF-1 signaling pathway has been considered a new strategy for cancer therapy, but translation into clinically available treatments remains challenging.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Quercetin acts as a P-gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain

Ashutosh Singh et al.

Summary: The resistance of cancer cells to chemotherapy is a major challenge in drug discovery. P-glycoprotein (P-gp) overexpression is directly linked to multidrug resistance (MDR) in cancer cells. Quercetin has been reported to inhibit the activity of P-gp, but the underlying mechanism is not fully understood. This study reveals the mechanistic understanding of quercetin-induced modulation of P-gp using molecular docking and molecular dynamics simulation.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Pharmacology & Pharmacy

Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC

Chunhong Su et al.

Summary: In this study, nanobubbles loaded with PDLIM5 siRNA were prepared, and their transfection efficiency and antagonism in drug resistance for NSCLC were investigated in combination with ultrasound irradiation. The results showed that this approach can effectively inhibit tumor cell growth and promote apoptosis.

DRUG DELIVERY (2022)

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Review Pharmacology & Pharmacy

Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects

Sepideh Mirzaei et al.

Summary: In this review, the molecular pathways regulating P-gp and its involvement in DOX resistance are highlighted. The development of nanocarriers for co-delivery of DOX with anticancer compounds and genes is also discussed. Furthermore, the surface modification of nanocarriers to enhance selectivity towards cancer cells is explored.

DRUG DISCOVERY TODAY (2022)

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Review Pharmacology & Pharmacy

Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance

Milad Ashrafizadeh et al.

Summary: Graphene oxide (GO) nanostructures can effectively deliver doxorubicin and enhance its cytotoxicity against cancer cells. By preparing stimuli-responsive GO nanocomposites, surface functionalization, and hybrid nanoparticles, the therapeutic potential of doxorubicin in cancer therapy can be maximized.

EXPERT OPINION ON DRUG DELIVERY (2022)

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A pH-sensitive liposome formulation of a peptidomimetic-Dox conjugate for targeting HER2+cancer

Jafrin Jobayer Sonju et al.

Summary: This research focuses on the use of a pH-sensitive liposomal formulation and a targeting ligand conjugated cytotoxic drug to achieve targeted delivery of chemotherapy. The results showed promising in vitro and in vivo studies, indicating improved anticancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Wenju Wei et al.

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Review Chemistry, Medicinal

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Asal Jalal Abadi et al.

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PHYTOTHERAPY RESEARCH (2022)

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The m6A methyltransferase METTL3 affects autophagy and progression of nasopharyngeal carcinoma by regulating the stability of lncRNA ZFAS1

Jiaojiao Peng et al.

Summary: This study confirmed the oncogenic role of ZFAS1 in NPC and elucidated its upregulation mechanism. Additionally, it was confirmed that ZFAS1 can regulate the autophagy level of NPC cells through the miR-100-3p/ATG10 pathway to affect tumor progression.

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Ratiometric co-delivery of doxorubicin and paclitaxel prodrug by remote-loading liposomes for the treatment of triple-negative breast cancer

Yingli Wang et al.

Summary: A liposomal nanoplatform with ratiometric design and remote loading is reported to co-encapsulate ROS-sensitive paclitaxel prodrug (PSN) and doxorubicin (DOX) for synergistic efficacy. The dual-delivery liposomes exhibit high encapsulation efficiency, colloidal stability, and potent synergistic anticancer activity by maintaining the ratiometric drug ratio in vivo.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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PEGylated versus Non-PEGylated pH-Sensitive Liposomes: New Insights from a Comparative Antitumor Activity Study

Shirleide Santos Nunes et al.

Summary: PEGylated liposomes are widely studied as drug delivery systems, but their interaction with cells may be hindered by the addition of PEG. This study compared the characteristics and drug delivery capabilities of PEGylated and non-PEGylated liposomes. The results showed that non-PEGylated liposomes had better cellular uptake and were more effective in controlling tumor growth.

PHARMACEUTICS (2022)

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Increased Targeting Area in Tumors by Dual-Ligand Modification of Liposomes with RGD and TAT Peptides

Mohamadreza Amin et al.

Summary: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids improve the pharmacokinetics of chemotherapeutics and reduce side-effects. However, cellular delivery and tumor heterogeneity are the main obstacles against tumor targeting. This study designed liposomes decorated with two ligands for enhanced cellular delivery and targeting of tumor vasculature and tumor cells.

PHARMACEUTICS (2022)

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PEG-grafted liposomes for enhanced antibacterial and antibiotic activities: An in vivo study

Seyed Ebrahim Alavi et al.

Summary: The study showed that loading NF into PEG-Lip can achieve controlled release for up to 50 hours, providing better antibacterial effects against MSSA biofilm-associated infections and reducing the side effects of NF.

NANOIMPACT (2022)

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Modelling the impact of nucleolin expression level on the activity of F3 peptide-targeted pH-sensitive pegylated liposomes containing doxorubicin

Rui Lopes et al.

Summary: Strategies targeting nucleolin have improved the intracellular bioavailability of encapsulated drugs. Mathematical modeling predicted drug exposure levels mediated by nucleolin, highlighting potential clinical applications, especially in targeted drug delivery.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Encapsulation of doxorubicin prodrug in heat-triggered liposomes overcomes off-target activation for advanced prostate cancer therapy

Sara Pereira et al.

Summary: In this study, the encapsulation of Dox-PSA into LTSL was successfully achieved, allowing controlled release upon temperature increase and improving the safety and biological activity of Dox-PSA. Efficient release, cleavage, and nuclear entry of Dox-PSA were observed in prostate cancer cells. Furthermore, Dox-PSA-loaded LTSL showed prolonged blood circulation, reduced cardiac toxicity, and improved therapeutic efficacy compared to free Dox-PSA. Lastly, the combination of Dox-PSA-loaded LTSL and HT delayed tumor growth, providing a safer option for the treatment of locally advanced prostate cancer.

ACTA BIOMATERIALIA (2022)

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Review Chemistry, Multidisciplinary

Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy

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Summary: This review summarizes the use of exosomes and liposomes in cancer diagnosis, therapy, and immunotherapy, as well as the recent advancements of exosome-liposome hybrid nanovesicles in cancer therapy.

ACTA PHARMACOLOGICA SINICA (2022)

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Liposomes-Based Nanoplatform Enlarges Ultrasound-Related Diagnostic and Therapeutic Precision

Ying Zhang et al.

Summary: Ultrasound, a safe and effective imaging modality in the medical field, has the potential for inducing bioeffects. The merging of liposome-based nanoplatforms and ultrasound-induced reactions offers new clinical strategies and a blueprint for future medicine.

CURRENT MEDICINAL CHEMISTRY (2022)

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SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression

Huixiao Yuan et al.

Summary: This study verified circFARSA as a novel target for pancreatic cancer treatment and prepared a novel anti-pancreatic cancer agent. The agent effectively inhibited the proliferation and migration of pancreatic cancer cells and showed good biological safety and anti-cancer effects in vivo.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Chemistry, Medicinal

pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma

Yi Zhao et al.

Summary: In this study, novel cascadetargeted liposomes (Lip-TPGS) were designed and prepared for synergistic treatment of glioma. These liposomes could intelligently deliver redox-sensitive doxorubicin prodrugs and a chemotherapeutic sensitizer, providing a promising drug delivery system with potential advantages in inhibiting proliferation, promoting apoptosis, inducing mitochondria dysfunction, inhibiting migration and invasion, prolonging survival time, and reducing toxicity.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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pH-temperature dual-sensitive nucleolipid-containing stealth liposomes anchored with PEGylated AuNPs for triggering delivery of doxorubicin

Monica C. Garcia et al.

Summary: This study reports the development of pH/thermo-sensitive liposomes using nucleolipids and modified with gold nanoparticles. The results demonstrate that these liposomes can efficiently release anticancer drugs and exhibit significant toxicity against cancer cells.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Oncology

The long and short non-coding RNAs modulating EZH2 signaling in cancer

Sepideh Mirzaei et al.

Summary: Non-coding RNAs play significant roles in cancer progression by regulating the expression of enhancer of zeste homolog 2 (EZH2). Different types of ncRNAs, including miRNAs, lncRNAs, and CircRNAs, modulate EZH2 expression through various mechanisms, affecting downstream signaling pathways and therapy response. These mechanisms have important implications for cancer research and treatment.

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Elevated Expression of SATB1 Predicts Unfavorable Clinical Outcomes in Colon Adenocarcinoma

Yujiang Li et al.

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APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2022)

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Live Macrophage-Delivered Doxorubicin-Loaded Liposomes Effectively Treat Triple-Negative Breast Cancer

Lan Yang et al.

Summary: This study demonstrates a system for treating triple-negative breast cancer by utilizing the tumor-targeting capabilities of macrophages. By loading doxorubicin-carrying liposomes on the surfaces of macrophages, the system significantly enhances drug accumulation at tumor sites, penetrates deeper into tumor tissue, and enhances the anti-tumor immune response, leading to improved survival rates in mice.

ACS NANO (2022)

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Preparation and evaluation of bismuth sulfide and magnetite-based theranostic nanohybrid as drug carrier and dual MRI/CT contrast agent

Hamed Nosrati et al.

Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.

APPLIED ORGANOMETALLIC CHEMISTRY (2022)

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MnO2-shelled Doxorubicin/Curcumin nanoformulation for enhanced colorectal cancer chemo-immunotherapy

Jie Liu et al.

Summary: A novel MnO2-shelled nanoplatform was constructed to load two FDA-approved anti-tumor drugs, Cur and Dox, achieving enhanced dual-chemotherapy of primary tumors and remarkable inhibition of distant colorectal tumors. The study demonstrated that MnO2 efficiently enhanced Dox/Cur chemotherapy with significant primary tumor inhibition at low dosages and promoted strong tumoricidal adaptive immune responses.

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Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy

Quan-Bing Chen et al.

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JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Folic Acid-Adorned Curcumin-Loaded Iron Oxide Nanoparticles for Cervical Cancer

Marzieh Ramezani Farani et al.

Summary: This study introduces the use of magnetic nanoparticles for cancer diagnosis and treatment. The results demonstrate that functionalized nanoparticles have a higher drug-loading capacity and are more likely to be taken up by tumors, making them potential drug delivery systems for cancer therapy. Additionally, when used for diagnosis, FA@HPG@Fe3O4 nanoparticles have the greatest impact on MRI signal enhancement.

ACS APPLIED BIO MATERIALS (2022)

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Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition

Fu-Yi Cai et al.

Summary: The study successfully constructed PFV modified DOX plus schisandrin B liposomes to inhibit NSCLC invasion and metastasis. In vitro experiments confirmed the anti-tumor efficacy of the targeting liposomes, while in vivo tests demonstrated a high tumor inhibition rate.

JOURNAL OF LIPOSOME RESEARCH (2021)

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Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance

Yan Zhou et al.

Summary: Our study revealed that Syncytin-1 expression is up-regulated in HCC, particularly in advanced stages, and can serve as a predictor of patient prognosis. Furthermore, detailed analysis showed a significant association between Syncytin-1 and HBsAg positivity in HCC patients, suggesting a key role in the development and treatment of HCC.

CELL DEATH DISCOVERY (2021)

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Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity

Dipsikha Biswas et al.

Summary: Triple-negative breast cancers (TNBCs) exhibit poor prognosis and resistance to cytotoxic chemotherapeutics like doxorubicin (DOX), with recent studies suggesting that inhibition of branched-chain ketoacid dehydrogenase kinase (BCKDK) may lead to cell death, ATP insufficiency, and increased susceptibility to genotoxic stress induced by DOX treatment.

CELL DEATH DISCOVERY (2021)

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Review Engineering, Biomedical

Recent Progress in the Development of Multifunctional Nanoplatform for Precise Tumor Phototherapy

Junjie Liu et al.

Summary: The key to precise tumor phototherapy is to ensure that ROS or heat is specifically generated at the tumor site, while the phototoxicity of conventional PAs is one of the main challenges for their potential clinical application. Through targeted delivery of PAs and activatable phototherapy strategies based on nanocarriers, precise treatment of tumors can be achieved.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Biomembrane-based nanostructures for cancer targeting and therapy: From synthetic liposomes to natural biomembranes and membrane-vesicles

Jing Wang et al.

Summary: The translational success of liposomes in chemotherapeutics has shown the potential of biomembrane-based nanostructures in drug delivery, while efforts are also being made in utilizing naturally derived lipid membranes for anti-cancer therapies. Despite differences in production and composition, the common phospholipid bilayer structure allows for modification and functionalization of liposomes, cell membrane-derived nanomaterials, and extracellular vesicles to combat challenges in tumor-targeted drug delivery. The review summarizes recent advancements in engineering membrane-derived nanostructures with intelligent modules for targeting tumor cells and the microenvironment in fighting malignancy, and discusses the potential of enhancing cancer therapy by combining engineered functionalities with naturally occurring activity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

Gemcitabine and doxorubicin in immunostimulatory monophosphoryl lipid A liposomes for treating breast cancer

Debra Wu et al.

Summary: Cancer therapy is increasingly focusing on targeting the tumor immune microenvironment, with chemotherapy inducing immunostimulatory responses that can be enhanced by immune-modulating agents. However, long-term immune responses may be lacking in some cases, despite initial efficacy against tumors.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

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pH-responsive and folate-coated liposomes encapsulating irinotecan as an alternative to improve efficacy of colorectal cancer treatment

Shirleide Santos Nunes et al.

Summary: A folate-coated pH-sensitive liposome drug delivery system for Irinotecan was developed to improve tumor therapy without potential adverse events. The system showed better antitumor activity compared to the pH-dependent system alone or free drug, with no evidence of systemic toxicity.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Chemistry, Applied

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Milad Ashrafizadeh et al.

Summary: Hyaluronic acid-modified nanostructures can enhance the delivery of doxorubicin to cancer cells, overcoming chemoresistance and providing a platform for the co-delivery of genes and drugs.

CARBOHYDRATE POLYMERS (2021)

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Polyelectrolyte/Gold Nanoparticle Nanotubes Incorporating Doxorubicin-Loaded Liposomes

Yuto Enomoto et al.

Summary: A unique structure of Doxorubicin-loaded liposomes (DoxLs) spontaneously absorbed into nanotubes comprising polyelectrolytes and gold nanoparticles was described, with efficient drug release induced by heating stimuli. The study also elucidated the antitumor activity of this structure on cancer cells.

CHEMISTRY-AN ASIAN JOURNAL (2021)

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Article Biochemistry & Molecular Biology

A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing

Yun He et al.

Summary: The development of multifunctional composite sponges incorporating traditional Chinese medicine Kangfuxin into alginate/carboxymethyl chitosan shows great potential for promoting wound healing, with properties such as suitable water vapor transmittance, antibacterial behavior, cytocompatibility, and rapid hemostasis. In a rat full-thickness wounds model, the composite sponge significantly facilitates wound closure compared to conventional wound dressings.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Nanoscience & Nanotechnology

DPPG2-Based Thermosensitive Liposomes with Encapsulated Doxorubicin Combined with Hyperthermia Lead to Higher Doxorubicin Concentrations in the Bladder Compared to Conventional Application in Pigs: A Rationale for the Treatment of Muscle-Invasive Bladder Cancer

F. Johannes P. van Valenberg et al.

Summary: The combination of intravenous DPPG2-TSL-DOX with hyperthermia achieved higher DOX concentrations in the bladder wall, including in the detrusor muscle, compared to conventional intravenous and intravesical DOX application. Furthermore, the DPPG2-TSL-DOX with hyperthermia led to lower DOX accumulation in the heart and kidneys, indicating its potential as a bladder-sparing treatment for muscle-invasive bladder cancer.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Doxorubicin liposomes cell penetration enhancement and its potential drawbacks for the tumor targeting efficiency

Hen Popilski et al.

Summary: The decoration of PEGylated doxorubicin liposomes (PLD) with cell penetration enhancers (CPEs) can increase tumor permeability and enhance anti-cancer effects in vivo, despite lower tumor accumulation. However, this may also lead to higher distribution to non-target organs and tissues. Further studies are needed to assess the mechanisms of CPE-mediated effects on liposome disposition.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Toxicology

被撤回的出版物: Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway (Retracted article. See vol. 41, 2022)

Yalikun Muhanmode et al.

Summary: The study confirmed that the combination of curcumin and resveratrol significantly sensitized EOC cells to cisplatin treatment by inhibiting chemoresistance through significant inhibition of the PI3K/AKT/mTOR pathway.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

KCa1.1 K+ Channel Inhibition Overcomes Resistance to Antiandrogens and Doxorubicin in a Human Prostate Cancer LNCaP Spheroid Model

Susumu Ohya et al.

Summary: Various types of potassium channels are crucial in tumorigenicity, stemness, invasiveness, and drug resistance in cancer. The inhibition of K(Ca)1.1 can overcome antiandrogen and DOX resistance in prostate cancer cells by targeting cancer stem cell markers and drug efflux pumps.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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A Reduction Active Theranostic Nanoparticle for Enhanced Near-Infrared Imaging and Phototherapy by Reducing Glutathione Level in Cancer Cells

Xiaofang Song et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes

Samara Bonesso dos Reis et al.

Summary: pH-sensitive liposomes showed fast accumulation and intracellular release of doxorubicin in tumor cells, leading to apoptosis. The cytotoxicity of pH-sensitive liposomes can be enhanced by chloroquine and E64d.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Medicine, Research & Experimental

All-Trans Retinoic Acid and Doxorubicin Delivery by Folic Acid Modified Polymeric Micelles for the Modulation of Pin1-Mediated DOX-Induced Breast Cancer Stemness and Metastasis

Yupeng Liu et al.

Summary: Stemness and metastasis pose major challenges in cancer therapy, often leading to chemoresistance and poor prognosis. Combination treatment, utilizing a delivery system for simultaneous administration of multiple drugs, has shown to be effective in addressing these issues.

MOLECULAR PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

Pooyan Makvandi et al.

Summary: This article discusses the exposure of humans to nanobiovectors and nanomaterials, as well as the interactions between cell membranes and these nanostructures, providing insights for scientists to design better biomedical nanomaterials. It also highlights the importance of understanding viral infections and their treatment.

NANO TODAY (2021)

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Article Pharmacology & Pharmacy

LinTT1 peptide-functionalized liposomes for targeted breast cancer therapy

Nicola D'Avanzo et al.

Summary: This study developed a targeting nanoparticle by conjugating LinTT1 peptide on liposomes, enhancing the cytotoxic effects of DOX and SRF on breast cancer cellular models. The functionalization of liposomes increased their interaction with breast cancer spheroids. Interaction studies with M2 macrophages suggest the potential use of these liposomes to enrich hypoxic tumor areas.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Medicine, Research & Experimental

The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Sepideh Mirzaei et al.

Summary: miRNA-338-3p regulates cancer growth and migration, potentially affecting cancer cell response to chemotherapy and radiotherapy. It seems to have a dual role in cancer chemotherapy as both a tumor-promoting and tumor-suppressing factor. Experiments indicate its anti-tumor activity in cancer, highlighting the importance of increasing miRNA-338-3p expression for effective cancer therapy.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Folate Receptor-Mediated Small Interfering RNA Delivery: Recent Developments and Future Directions for RNA Interference Therapeutics

Sumit Gangopadhyay et al.

Summary: RNA interference (RNAi) has shown promising potential as a therapeutic agent against various diseases, but faces challenges such as poor systemic delivery and vulnerability to nucleases. Targeting ligand-bound delivery vehicles can enhance drug accumulation at the target site, leading to high transfection efficiency and improved gene silencing. Folate receptor (FR)-mediated targeted delivery of siRNAs has gained attention for its enhanced cellular uptake and high transfection efficiency in tumor cells.

NUCLEIC ACID THERAPEUTICS (2021)

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LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma

Xiaoping Li et al.

Summary: The study demonstrates that lncRNA lncTRPM2-AS is involved in promoting macrophage inflammation in asthma by regulating apoptotic pathways and cytokine production. Interaction between TRPM2, lncTRPM2-AS, and TRIM21 affects ubiquitination levels, calcium ion levels, and subsequently autophagy in macrophages. Downregulation of lncTRPM2-AS inhibits ubiquitination of TRPM2 and enhances autophagy-induced apoptosis, contributing to the inhibition of macrophage inflammation.

CELL DEATH & DISEASE (2021)

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Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy

Ling Yu et al.

Summary: A photo-activatable liposome incorporating both photosensitizer Ce6 and chemotherapeutic drug TP was designed for controlled drug release and synergistic photodynamic therapy in treating HCC. This novel approach showed improved therapeutic effects with reduced side effects, making it a potential treatment option for HCC.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Biochemistry & Molecular Biology

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

Sepideh Mirzaei et al.

Summary: Doxorubicin (DOX) is commonly used in cancer therapy for its efficacy, but its dose-dependent toxicity has led to the study of mechanisms underlying DOX resistance, with a focus on the importance of Nrf2 signaling in alleviating its adverse effects.

ANTIOXIDANTS (2021)

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Article Medicine, Research & Experimental

Liposomes co-encapsulating doxorubicin and glucoevatromonoside derivative induce synergic cytotoxic response against breast cancer cell lines

M. V. M. Novais et al.

Summary: Cancer is a major global public health problem, with current chemotherapy drug DOX limited by cardiotoxicity. To address this issue, research has developed drug-loaded liposomes to enhance the therapeutic effect in cancer treatment.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/ mTOR pathways

Song Hu et al.

Summary: The study found that Chaetocochin J (CJ) exhibits potent anti-colorectal cancer activity by inducing both apoptosis and autophagy in CRC cells. CJ exerts its function through AMPK and PI3K/AKT/mTOR pathways, suggesting it may be a potential drug candidate for CRC treatment.

BIOORGANIC CHEMISTRY (2021)

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Review Chemistry, Applied

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

Milad Ashrafizadeh et al.

Summary: Gene therapy using siRNA faces challenges, but chitosan nanoparticles as carriers show promise in overcoming siRNA issues and demonstrating potential in cancer therapy.

CARBOHYDRATE POLYMERS (2021)

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Article Pharmacology & Pharmacy

Microfluidic-assisted fabrication of phosphatidylcholine-based liposomes for controlled drug delivery of chemotherapeutics

Leonidas Gkionis et al.

Summary: Microfluidics technology enables precise control over the continuous mixing of fluid phases at the micrometre scale, aiming to optimize processing parameters and facilitate scale-up feasibility. This study successfully utilized microfluidics to rapidly screen manufacturing parameters and phosphatidylcholine formulations to obtain monodispersed and stable liposomal formulations with a narrow size distribution, which showed sustained release of doxorubicin. The drug release profiles varied as a function of DMPC/DSPC mol content in the lipid bilayer, with DMPC-based liposomes exhibiting sustained release compared to DSPC liposomes.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Oncology

Oncogenic KRAS: Signaling and Drug Resistance

Hyeon Jin Kim et al.

Summary: KRAS is an oncogenic protein in human cancers, with abnormal mutated and GTP-bound KRAS being highly expressed. Understanding the biological characteristics and precise signaling of KRAS proteins is essential for targeted cancer therapy. The review also explores the recent progress in KRAS-targeted anticancer, providing new insight for cancer therapy.

CANCERS (2021)

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Review Cell Biology

Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy

Sepideh Mirzaei et al.

Summary: Pancreatic cancer (PC) is a leading cause of death and the fourth most malignant tumor in men. siRNA can effectively target critical genes in PC progression and enhance the efficacy of chemotherapy and radiotherapy. Loading siRNAs on nanoparticles can protect them from degradation and improve targeted delivery, leading to enhanced therapeutic efficacy in PC treatment.

CELLS (2021)

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Article Pharmacology & Pharmacy

PEGylated Liposomes Remotely Loaded with the Combination of Doxorubicin, Quinine, and Indocyanine Green Enable Successful Treatment of Multidrug-Resistant Tumors

Emma Grabarnick (Portnoy) et al.

Summary: The study demonstrated that the combined treatment of liposomal doxorubicin, P-gp inhibitor quinine, and photodynamic therapy with indocyanine green can overcome multidrug resistance in cancer cells, particularly showing significant therapeutic effects in an adenocarcinoma drug-resistant tumor model.

PHARMACEUTICS (2021)

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Article Chemistry, Medicinal

Leukocyte-Mimetic Liposomes Penetrate Into Tumor Spheroids and Suppress Spheroid Growth by Encapsulated Doxorubicin

Tatsuya Fukuta et al.

Summary: The study showed that leukocyte-mimetic liposomes containing leukocyte membrane proteins can effectively penetrate into tumor spheroids, inhibit tumor growth, and potentially serve as a drug delivery system for cancer treatment. Transferring leukocyte membrane proteins onto liposomes enhances their binding capacity with tumor cells, demonstrating the ability for efficient penetration into tumors.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Functionalised molybdenum disulfide nanosheets for co-delivery of doxorubicin and siRNA for combined chemo/gene/photothermal therapy on multidrug-resistant cancer

Guo Li et al.

Summary: A multifunctional nano-drug delivery system based on MoS2 was successfully developed for combined chemo/gene/photothermal therapy, showing good biocompatibility, controlled drug release, and enhanced therapeutic efficacy against drug-resistant cancer cells.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Article Chemistry, Medicinal

Luteolin-Loaded Elastic Liposomes for Transdermal Delivery to Control Breast Cancer: In Vitro and Ex Vivo Evaluations

Mohammad A. Altamimi et al.

Summary: The study aimed to prepare and optimize luteolin-loaded transdermal elastic liposomes for controlling breast cancer. The optimized formulation showed improved drug release, entrapment, and permeation rate, leading to promising results in inhibiting breast cancer cells.

PHARMACEUTICALS (2021)

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Article Biology

The Long Non-Coding RNA SAMMSON Is a Regulator of Chemosensitivity and Metabolic Orientation in MCF-7 Doxorubicin-Resistant Breast Cancer Cells

Charlotte Orre et al.

Summary: Breast cancer is a common cancer among women, with chemoresistance being a major issue in patient outcomes. Long non-coding RNA SAMMSON has been found to play a role in metabolic reprogramming and chemoresistance in breast cancer cells, providing a potential therapeutic target for overcoming drug resistance.

BIOLOGY-BASEL (2021)

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Article Chemistry, Multidisciplinary

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Nuno A. Fonseca et al.

Summary: Targeting nucleolin overexpressed in tumor endothelial cells in addition to cancer cells can reduce dependence on high systemic exposure and the EPR effect for successful tumor targeting. PEGASEMP shows significant antitumor activity against nucleolin-overexpressing solid tumors compared to standard treatment, with potential therapeutic impact.

NANO TODAY (2021)

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Review Pharmacology & Pharmacy

Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

Sepideh Mirzaei et al.

Summary: Nrf2 signaling plays a crucial role in protecting against oxidative damage, but its activation in cancer cells can lead to chemoresistance. Modulating Nrf2 signaling during cisplatin treatment can suppress the development of chemoresistance and alleviate drug toxicity. Activating Nrf2 signaling can help prevent the side effects of cisplatin.

PHARMACOLOGICAL RESEARCH (2021)

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Article Multidisciplinary Sciences

Ultrasound-triggered herceptin liposomes for breast cancer therapy

Amal Elamir et al.

Summary: Functionalizing liposomes with monoclonal antibodies, particularly anti-HER2 antibodies, can enhance targeted drug delivery to HER2 positive breast cancer cells. Low frequency ultrasound (LFUS) triggered drug release from liposomes can be further enhanced by the conjugation of Trastuzumab, increasing drug uptake and cellular toxicity in HER2+ cell lines. Combining immunoliposomes with LFUS is a promising technique to improve drug delivery efficiency and reduce cytotoxicity of antineoplastic drugs.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Mitochondria-targeting graphene oxide nanocomposites for fluorescence imaging-guided synergistic phototherapy of drug-resistant osteosarcoma

Wei-Nan Zeng et al.

Summary: This study proposed a new nano-drug delivery system targeting drug-resistant osteosarcoma by using mitochondria-targeted phototherapy. The system showed highly selective anticancer efficiency through fluorescence imaging-guided synergistic phototherapy, inducing intrinsic apoptosis to overcome drug resistance and cause tumor cell death.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

ROS-responsive liposomes with NIR light-triggered doxorubicin release for combinatorial therapy of breast cancer

Hanxi Yi et al.

Summary: Lipo/pB-DOX/ICG is a novel tool for on-demand drug release at tumor sites and a promising candidate for controllable and accurate combinatorial tumor therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis

Zhiwei Zhang et al.

Summary: The development of chondroitin sulfate liposomes (CSLs) for the co-delivery of retinoic acid (RA) and doxorubicin (DOX) shows promising results in suppressing lung metastasis of breast cancer. CSLs efficiently encapsulate both RA and DOX and demonstrate better anticancer and anti-metastatic activity compared to other drug carriers.

PHARMACEUTICS (2021)

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Article Nanoscience & Nanotechnology

Glucose and Triphenylphosphonium Co-Modified Redox-Sensitive Liposomes to Synergistically Treat Glioma with Doxorubicin and Lonidamine

Yao Peng et al.

Summary: The study successfully delivered doxorubicin and lonidamine to glioma cells using multitargeted redox-sensitive liposomes, showing a synergistic effect with significant anti-tumor efficacy by inhibiting cell proliferation and inducing apoptosis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Keratin-Based Nanoparticles with Tumor-Targeting and Cascade Catalytic Capabilities for the Combinational Oxidation Phototherapy of Breast Cancer

Ting-Yu Lu et al.

Summary: Photodynamic therapy (PDT) is a promising cancer treatment strategy, but its efficacy is limited by factors such as hypoxic tumor microenvironment and inadequate tumor-targeted delivery of photosensitizers. Researchers have developed a novel approach using keratin as an NO generator to enhance PDT effectiveness, which successfully suppressed the growth of breast cancer cells.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy

Lili Cheng et al.

Summary: The designed hybrid therapeutic nanovesicles, hGLV, based on CD47 immune checkpoint blockade demonstrated long blood circulation, improved macrophage-mediated phagocytosis of tumor cells by blocking CD47 signal, targeted homologous tumors in mice effectively for preferential accumulation at tumor sites. Furthermore, hGLV loaded with photothermal agent achieved excellent photothermal therapy (PTT) in eliminating tumors, inducing immunogenic cell death, generating tumor-associated antigens, and promoting immune responses with the help of co-encapsulated immune adjuvant. Such hybrid nanovesicles show promise in drug delivery for cancer treatment.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy

Fengying Lu et al.

Summary: This study utilized HBc VLPs as carriers for loading IR780 and discovered a temperature and ionic strength-dependent mechanism for drug encapsulation. By simple mixing, a high density of drug loading was achieved, improving the stability and therapeutic performance of IR780, providing a new solution for cancer phototherapies.

BIOMATERIALS (2021)

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Article Oncology

Long non-coding RNAs in the doxorubicin resistance of cancer cells

Saeed Ashrafizaveh et al.

Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.

CANCER LETTERS (2021)

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Article Oncology

Regulation of Nuclear Factor-KappaB (NF-kB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Sepideh Mirzaei et al.

Summary: The NF-xB signaling pathway is a potential therapeutic target in cancer therapy, with its dysregulation impacting cancer cell proliferation, metastasis, and resistance to radiotherapy and chemotherapy. Non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, play a crucial role in modulating NF-xB signaling and may affect cancer progression by regulating miRNAs targeting NF-xB activation.

CANCER LETTERS (2021)

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Article Oncology

Resveratrol for cancer therapy: Challenges and future perspectives

Boxu Ren et al.

Summary: Despite its potential anticancer effects, resveratrol faces obstacles in clinical translation due to poor pharmacokinetics, low potency, and nephrotoxicity in certain patients. New strategies to enhance its bioavailability and develop more potent analogues are proposed to overcome these challenges and advance resveratrol in cancer therapy.

CANCER LETTERS (2021)

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Article Biophysics

Triphenylamine-perylene diimide conjugate-based organic nanoparticles for photoacoustic imaging and cancer phototherapy

Haolan Li et al.

Summary: A new organic compound PIT with a typical D-A-D structure was designed and synthesized, and its NPs exhibited good water dispersibility, high photothermal conversion efficiency, and strong photoacoustic signal, inducing significant reactive oxygen species. These PIT NPs showed good biocompatibility and outstanding photocytotoxicity, making them excellent candidates for photoacoustic imaging and photodynamic/photothermal therapy.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Biochemistry & Molecular Biology

Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence

Mahshid Deldar Abad Paskeh et al.

Summary: miRNA-489 serves as a tumor suppressor in various cancers by sensitizing cancer cells to chemotherapy, inhibiting metastasis, and disrupting oncogenic pathways. Restoring miRNA-489 expression could enhance drug sensitivity in tumors and potentially serve as a diagnostic tool for cancer detection.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Battling Chemoresistance in Cancer: Root Causes and Strategies to Uproot Them

Alisha Ramos et al.

Summary: Cancer, with nearly 10 million deaths worldwide, remains a leading cause of mortality. Chemoresistance, whether intrinsic or acquired, causes cancer recurrence and treatment failure. Strategies to combat chemoresistance include early diagnosis and combination therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Liposomes Loaded with Everolimus and Coated with Hyaluronic Acid: A Promising Approach for Lung Fibrosis

Laura Pandolfi et al.

Summary: The study demonstrated the potential use of nanomedicine to encapsulate everolimus inside liposomes targeted against LFs with high CD44 expression, reducing its side effects. The PEG-LIP(ev)-HA400kDa showed specificity for LFs and anti-inflammatory effects on immune cells, indicating the possibility of using everolimus in lung fibrotic diseases through lipid-based vehicles.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition

Yu-Xin Liao et al.

Summary: This study demonstrated that inhibition of CXCR4 sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death, suggesting that targeting the CXCR4/autophagy axis may be a promising therapeutic strategy to overcome chemotherapy resistance in osteosarcoma.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Review Pharmacology & Pharmacy

Combining gene therapy with other therapeutic strategies and imaging agents for cancer theranostics

Alexandro Azevedo et al.

Summary: Cancer is a prevalent and deadly disease in need of new preventive and treatment strategies. The fields of cancer nanomedicine and nanotheranostics offer opportunities for personalized and targeted therapy through combining imaging and therapeutic agents. Gene therapy is a promising approach that requires efficient delivery systems, and recent developments in theranostic nanosystems are exploring the integration of gene therapy and imaging for cancer treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin

Shen-Jun Yuan et al.

Summary: This study revealed that Nano-DOX, conjugated with polyglycerol-coated nanodiamonds, exhibited distinct intracellular distribution compared to free DOX. Nano-DOX induced less endoplasmic reticulum stress and DNA damage, as well as weaker pro-inflammatory signaling pathway activation, when compared to free DOX. These findings suggest that chemotherapy in nano form can have altered cellular effects of the drug.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Applied

Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells

Reyhan Dilsu Colpan et al.

Summary: This study synthesized quercetin-caffeic-acid phenethyl ester co-loaded PLGA nanoparticles and demonstrated their improved anti-cancer activity on human colorectal carcinoma cells, indicating promising potential for cancer treatment.

JOURNAL OF MICROENCAPSULATION (2021)

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Review Medicine, Research & Experimental

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

Sepideh Mirzaei et al.

Summary: GBM is a serious brain tumor with no cure, requiring new genetic approaches for treatment. The use of siRNA can target and silence genes responsible for disease progression in GBM cells.

LIFE SCIENCES (2021)

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Review Medicine, Research & Experimental

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy

Sepideh Mirzaei et al.

Summary: siRNA can enhance sensitivity of cancer cells to chemotherapy by down-regulating specific genes, inhibiting cancer stem cell properties and related molecular pathways, as well as promoting cell cycle arrest and increased accumulation of chemotherapy drugs in cancer cells. Carriers such as nanoparticles and biological carriers are important in overcoming siRNA challenges and enhancing its effectiveness in reversing chemotherapy resistance.

LIFE SCIENCES (2021)

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Article Oncology

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes

Yoshiyuki Hattori et al.

Summary: This study investigated the effects of sterol derivatives in systemically injected siRNA/cationic liposome complexes on gene-knockdown in the lungs of mice. The results showed that DDAB/Chol and DDAB/Ergo liposomes could function as vectors for siRNA delivery to the lungs, effectively increasing the suppression of Tie2 mRNA expression in mice.

MOLECULAR MEDICINE REPORTS (2021)

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Article Medicine, Research & Experimental

Multifunctional Traceable Liposomes with Temperature-Triggered Drug Release and Neovasculature-Targeting Properties for Improved Cancer Chemotherapy

Eiji Yuba et al.

Summary: This study aims to enhance the therapeutic effect of liposomes by accumulating doxorubicin-loaded liposomes at high concentrations in and around the tumor, followed by heat trigger drug release to facilitate low-molecular-weight drug penetration throughout the tumor. The targeted thermosensitive liposomes successfully inhibited tumor growth and achieved tumor remission through multiple administrations and heat treatments. Combining tumor neovascular targeting and heat-triggered drug release, these liposomes offer high potential for minimally invasive and effective cancer chemotherapy.

MOLECULAR PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Preparation, characterization, and anti-colon cancer activity of oridonin-loaded long-circulating liposomes

Chunxiao Gao et al.

Summary: LC-lipo@ORI, prepared via the ethanol injection method, showed promising stability and long circulation characteristics. It demonstrated effective inhibition of tumor cell proliferation and significant suppression of tumor growth.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Co-Delivery Using pH-Sensitive Liposomes to Pancreatic Cancer Cells: the Effects of Curcumin on Cellular Concentration and Pharmacokinetics of Gemcitabine

Hongtao Xu et al.

Summary: Co-delivery of curcumin with gemcitabine using PSL not only increased the intracellular gemcitabine concentration and cytotoxicity to MIA PaCa-2 cells, but also significantly improved the pharmacokinetic profiles for both drugs.

PHARMACEUTICAL RESEARCH (2021)

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Review Pharmacology & Pharmacy

Aldo-Keto Reductases and Cancer Drug Resistance

Trevor M. Penning et al.

Summary: Human aldo-keto reductases (AKRs) play a crucial role in mediating resistance to cancer chemotherapeutics and antihormonal therapies by either directly metabolizing the drugs or helping eliminate cellular stress caused by them. Inhibitors targeting the NRF2 system or pan-AKR1C offer promise in combating cancer drug resistance and enhancing clinical outcomes.

PHARMACOLOGICAL REVIEWS (2021)

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Article Toxicology

Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/ TGF-β mediated transcription and sensitize the gastric cancer cells to doxorubicin

Ponmathi Panneerpandian et al.

Summary: Elevated expression of YY1 confers anti-apoptotic phenotype, making it an attractive target for cancer therapeutics. Calcium channel blockers lercanidipine and amlodipine have been identified to inhibit YY1 more efficiently in gastric cancer cells, and enhance the inhibitory effect of doxorubicin on gastric cancer cell growth by inhibiting pathways activated by doxorubicin. This study demonstrates the potential of these calcium channel blockers in sensitizing gastric cancer cells to doxorubicin and improving treatment efficiency.

TOXICOLOGY IN VITRO (2021)

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Article Multidisciplinary Sciences

Transferrin-modified liposomes triggered with ultrasound to treat HeLa cells

Nour M. AlSawaftah et al.

Summary: Targeted liposomes triggered with ultrasound enable controlled drug release and reduce side effects. Transferrin-conjugated pegylated liposomes are more sensitive to ultrasound and exhibit higher drug uptake ability.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds

Vivek P. P. Chavda et al.

Summary: Investigations into natural chemical compounds for their programmed necrosis potential have led to the emergence of multi-target drugs and new drug discovery methods like fragment-based drug discovery for natural anticancer agents.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles

Daniel W. Binzel et al.

Summary: siRNA as a therapeutic tool has made significant progress, especially in the treatment of cancer, with promising prospects. However, siRNA therapy still faces challenges that require further research to address.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Chemistry, Multidisciplinary

Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances

Yavuz Nuri Ertas et al.

Summary: Cancer stem cells (CSCs) play a crucial role in tumor growth, metastasis, recurrence, and drug resistance. They are maintained within a niche by unique factors in the microenvironment. Using nanoparticles as carriers for anticancer drugs enables targeted delivery to CSCs, contributing to advancements in cancer therapy.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates

Miguel Gisbert-Garzaran et al.

Summary: Mesoporous silica nanoparticles are widely used in cancer treatment, with a focus on redox-responsive systems. This trend in design includes biological rationale, gatekeeper types, and nucleic acid scaffold nanoparticles.

NANOMATERIALS (2021)

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Article Materials Science, Biomaterials

Self-Assembled pH-Sensitive Nanoparticles Based on Ganoderma lucidum Polysaccharide-Methotrexate Conjugates for the Co-delivery of Anti-tumor Drugs

Dan Zheng et al.

Summary: A novel pH-sensitive nanoparticle drug delivery system based on Ganoderma lucidum polysaccharides was designed for efficient delivery of MTX and HCPT to tumor cells, exhibiting synergistic anti-tumor effects. These irregularly spherical nanoparticles with uniform size demonstrated high drug-loading capacity and excellent biocompatibility. The loaded drugs were rapidly released within tumor cells under acidic conditions, showing better tumor suppression and fewer side effects in vivo compared to free drugs.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Cell Biology

CK2α/CSNK2A1 Induces Resistance to Doxorubicin through SIRT6-Mediated Activation of the DNA Damage Repair Pathway

Usama Khamis Hussein et al.

Summary: CK2 alpha/CSNK2A1 is involved in cancer progression by phosphorylating signaling molecules, and its phosphorylation of SIRT6 may lead to chemoresistance in osteosarcoma patients. Higher expression of CSNK2A1 and phosphorylated SIRT6 is associated with shorter survival in osteosarcoma patients. Overexpression of CSNK2A1 results in resistance to doxorubicin, possibly through activation of the DNA damage repair pathway.

CELLS (2021)

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Article Pharmacology & Pharmacy

Co-Delivery of Curcumin and Bioperine via PLGA Nanoparticles to Prevent Atherosclerotic Foam Cell Formation

Sindhu C. Pillai et al.

Summary: Nutraceuticals, such as curcumin, have shown potential benefits in treating and preventing cardiovascular diseases, including atherosclerosis. The development of nano-drug delivery systems, like Cur-Bio PLGA NPs, offers a promising approach to target atherosclerotic plaque sites effectively. The combination of curcumin and Bioperine in this system demonstrated enhanced reduction in cholesterol content and downregulation of inflammatory pathways associated with atherosclerosis, highlighting the importance of natural-based compounds in therapeutic interventions.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Hyaluronic Acid Coating Reduces the Leakage of Melittin Encapsulated in Liposomes and Increases Targeted Delivery to Melanoma Cells

Yanyan Li et al.

Summary: The study successfully reduced the toxicity and increased the anti-tumor effects of melittin by designing melittin liposomes and HA-modified melittin liposomes.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Construction of Hierarchical-Targeting pH-Sensitive Liposomes to Reverse Chemotherapeutic Resistance of Cancer Stem-like Cells

Shuang Ba et al.

Summary: A novel mitochondria-target derivate, when encapsulated with doxorubicin in pH-sensitive liposomes, successfully reversed chemotherapeutic resistance of cancer stem-like cells.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy

Daniil V. Gladkikh et al.

Summary: The study shows that liposome F is not toxic in healthy mice and can accumulate rapidly in tumors with high folate receptor levels. Combined therapy including anti-MDR1 siRNA/F complexes and polychemotherapy can significantly inhibit the growth of multidrug-resistant tumors without inducing liver toxicity.

PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

A Screening Study for the Development of Simvastatin-Doxorubicin Liposomes, a Co-Formulation with Future Perspectives in Colon Cancer Therapy

Cristina Ioana Barbalata et al.

Summary: The study focused on exploring the pharmaceutical development of liposomes co-encapsulating SIM and DOX to enhance their antiproliferative effects on colorectal cancer cells. It was found that the quality profile of liposomes is influenced by critical quality attributes, which are in turn affected by formulation factors and processing parameters. Delivery of the optimal drug ratio at the target site is crucial for balancing antiproliferative and pro-proliferative effects.

PHARMACEUTICS (2021)

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Article Cell Biology

Surface PEGylated Cancer Cell Membrane-Coated Nanoparticles for Codelivery of Curcumin and Doxorubicin for the Treatment of Multidrug Resistant Esophageal Carcinoma

Yi Gao et al.

Summary: In this study, a targeted biomimetic nano-drug delivery system PMPNs was successfully prepared, which overcome the MDR of esophageal carcinoma by co-delivering DOX and sensitizer curcumin. PMPNs could directly target TE10 and TE10/DOX cells or TE10/DOX xenografted tumor and effectively inhibit the growth of DOX-resistant esophageal carcinoma. Besides, the PMPNs was confirmed to have high biosafety.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Engineering, Biomedical

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Xuanbo Zhang et al.

Summary: Phototherapy as a non-invasive cancer treatment option faces challenges such as unsatisfactory therapeutic efficacy and severe phototoxicity. A new nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs has been developed to improve treatment efficiency and safety. The FRET pair-based nanoassembly allows controlled release of photosensitizer for photodynamic therapy, enhancing treatment efficacy while minimizing phototoxicity.

BIOACTIVE MATERIALS (2021)

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Article Materials Science, Biomaterials

A biodegradable multifunctional nanoplatform based on antimonene nanosheets for synergistic cancer phototherapy and dual imaging

Xiaokang Jin et al.

Summary: The study introduced a versatile nanoplatform using antimonene nanosheets coated with biodegradable chitosan, loaded with small molecule photosensitizer IR820 and gold nanoparticles. This system demonstrated excellent photothermal and photodynamic properties, satisfactory degradability, photoacoustic imaging ability, good biocompatibility, and effective intracellular synergistic treatment triggered by near infrared light.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

A multifunctional nano-delivery system enhances the chemo-co-phototherapy of tumor multidrug resistance via mitochondrial-targeting and inhibiting P-glycoprotein-mediated efflux

Runze Zhao et al.

Summary: A new nano-delivery system combining a P-glycoprotein inhibitor with chemotherapy and phototherapy has been developed to overcome drug efflux in multidrug-resistant (MDR) tumors, achieving a synergistic therapeutic effect.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Pharmacology & Pharmacy

Co-delivery of sorafenib and crizotinib encapsulated with polymeric nanoparticles for the treatment of in vivo lung cancer animal model

Tian Zhong et al.

Summary: Polymer nanoparticles have enhanced the effectiveness of anticancer drugs, with biodegradable PECE polymeric NPs co-delivering sorafenib and crizotinib for lung cancer treatment. Both in vitro and in vivo studies have shown promising results in terms of tumor reduction and overall therapeutic efficacy.

DRUG DELIVERY (2021)

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Article Materials Science, Biomaterials

Enhanced transdermal efficiency of curcumin-loaded peptide-modified liposomes for highly effective antipsoriatic therapy

Fan Yu et al.

Summary: CRC-TD-Lip is a potential drug-loaded liposome that accelerates the transdermal delivery of curcumin and enhances the antipsoriatic effect, demonstrating improved intracellular uptake, increased inhibitory effect on HaCaT cells, and enhanced transdermal ability.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Materials Science, Biomaterials

pH-Sensitive nanogels for drug delivery in cancer therapy

Zhen Li et al.

Summary: Nanogels are considered ideal drug carriers for cancer treatment due to their high stability, water content, and drug loading capacities. pH-sensitive nanogels, which utilize the lower pH value in tumor tissue, have shown potential for more precise drug delivery and release in cancer treatment.

BIOMATERIALS SCIENCE (2021)

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Article Surgery

Novel Pancreatic Cancer Therapy Targeting Cell Surface Glycans by Liposomes Modified with rBC2LCN Lectin

Sota Kimura et al.

Summary: This study developed a novel glycan-targeting nanoparticle, Lec-Doxosome, by modifying the surface of doxorubicin-containing liposomes with rBC2LCN lectin. In vitro and in vivo experiments demonstrated that Lec-Doxosome showed higher intracellular doxorubicin accumulation and stronger cytotoxicity compared to unmodified liposomes, leading to decreased tumor weight without additional adverse events. The results suggest that rBC2LCN lectin is an effective modifier for enhancing nanoparticle efficiency in targeting cancer cell surface glycans.

EUROPEAN SURGICAL RESEARCH (2021)

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Article Materials Science, Biomaterials

pH-Sensitive branched beta-glucan-modified liposomes for activation of antigen presenting cells and induction of antitumor immunity

Shin Yanagihara et al.

Summary: The study utilized branched beta-glucan as a naturally immune-stimulating and biocompatible material to develop multifunctional liposomal cancer vaccines that efficiently interacted with APCs and activated cells. The Aqua beta derivative-modified liposomes were pH-sensitive and capable of releasing their contents in response to weakly acidic pH, leading to efficient interaction with dendritic cells and induction of antitumor immune responses within the tumor microenvironment.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Pharmacology & Pharmacy

Alpha-tocopheryl succinate improves encapsulation, pH-sensitivity, antitumor activity and reduces toxicity of doxorubicin-loaded liposomes

F. A. Boratto et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Pharmacology & Pharmacy

Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells

Francesca Rolle et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Engineering, Biomedical

Bispecific antibody (HER2 x mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes

I-Ju Chen et al.

ACTA BIOMATERIALIA (2020)

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Article Oncology

Combining doxorubicin with stearylamine-bearing liposomes elicits Th1 cytokine responses and cures metastasis in a mouse model

Manjarika De et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Pharmacology & Pharmacy

Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy

Jiang Yu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Nanoscience & Nanotechnology

Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal

Ya-Xuan Zhu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

Low molecular weight heparin modified bone targeting liposomes for orthotopic osteosarcoma and breast cancer bone metastatic tumors

Hao Wu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy

Yan Wei et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

A Novel CD133-and EpCAM-Targeted Liposome With Redox-Responsive Properties Capable of Synergistically Eliminating Liver Cancer Stem Cells

Zihua Wang et al.

FRONTIERS IN CHEMISTRY (2020)

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Review Medicine, Research & Experimental

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Chunyan Liu et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Article Pharmacology & Pharmacy

Efficiency of Different Treatment Regimens Combining Anti-tumor and Anti-inflammatory Liposomes for Metastatic Breast Cancer

Jingxuan Liu et al.

AAPS PHARMSCITECH (2020)

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Article Pharmacology & Pharmacy

Cell targeting strategy affects the intracellular trafficking of liposomes altering loaded doxorubicin release kinetics and efficacy in endothelial cells

Anthoula Arta et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Review Medicine, Research & Experimental

Curcumin in cancer therapy: A novel adjunct for combination chemotherapy with paclitaxel and alleviation of its adverse effects

Milad Ashrafizadeh et al.

LIFE SCIENCES (2020)

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Article Materials Science, Biomaterials

Magnetic resonance activatable thermosensitive liposomes for controlled doxorubicin delivery

Mohamad Alawak et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Chemistry, Multidisciplinary

Enhanced In Vitro Magnetic Cell Targeting of Doxorubicin-Loaded Magnetic Liposomes for Localized Cancer Therapy

Eugenio Redolfi Riva et al.

NANOMATERIALS (2020)

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Article Oncology

Schisandrin B synergizes docetaxel-induced restriction of growth and invasion of cervical cancer cells in vitro and in vivo

Chunmei Yan et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Nanoscience & Nanotechnology

Tuftsin-Bearing Liposomes Co-Encapsulated with Doxorubicin and Curcumin Efficiently Inhibit EAC Tumor Growth in Mice

Kalaimathi Murugesan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

Encapsulated doxorubicin crystals influence lysolipid temperature-sensitive liposomes release and therapeutic efficacy in vitro and in vivo

Amalia Ruiz et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Genetics & Heredity

Schisandrin B Inhibits Cell Viability and Migration, and Induces Cell Apoptosis by circ_0009112/miR-708-5p Axis Through PI3K/AKT Pathway in Osteosarcoma

Bing Wang et al.

FRONTIERS IN GENETICS (2020)

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Article Nanoscience & Nanotechnology

NIR-Triggered Chemo-Photothermal Therapy by Thermosensitive Gold Nanostar@Mesoporous Silica@Liposome-Composited Drug Delivery Systems

Zheng Cai et al.

ACS APPLIED BIO MATERIALS (2020)

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Review Pharmacology & Pharmacy

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Milad Ashrafizadeh et al.

PHARMACEUTICS (2020)

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Article Materials Science, Biomaterials

Sialic acid-conjugate modified liposomes targeting neutrophils for improved tumour therapy

Cong Li et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Liposomes co-delivery system of doxorubicin and astragaloside IV co-modified by folate ligand and octa-arginine polypeptide for anti-breast cancer

Guijuan Yue et al.

RSC ADVANCES (2020)

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Article Biochemistry & Molecular Biology

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

Zhaowu Ma et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Pharmacology & Pharmacy

Effective co-encapsulation of doxorubicin and irinotecan for synergistic therapy using liposomes prepared with triethylammonium sucrose octasulfate as drug trapping agent

Jieru Liu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Chemistry, Multidisciplinary

Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals

Dandan Luo et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Physical

Surface Modification of Liposomes by a Lipopolymer Targeting Prostate Specific Membrane Antigen for Theranostic Delivery in Prostate Cancer

Hooman Yari et al.

MATERIALS (2019)

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Review Oncology

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

Bethsebie Lalduhsaki Sailo et al.

CANCERS (2019)

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Article Pharmacology & Pharmacy

Dual-Ligand Modification of PEGylated Liposomes Used for Targeted Doxorubicin Delivery to Enhance Anticancer Efficacy

Cong Li et al.

AAPS PHARMSCITECH (2019)

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Article Biochemistry & Molecular Biology

Synergistic effect of phototherapy and chemotherapy on bladder cancer cells

Mehdi Shakibaie et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2019)

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Article Nanoscience & Nanotechnology

Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (-TOS) for Anti-Metastasis

Maoyuan Song et al.

NANOSCALE RESEARCH LETTERS (2019)

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Article Biophysics

Doxorubicin loaded tumor-triggered targeting ammonium bicarbonate liposomes for tumor-specific drug delivery

Yang Cheng et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Medicine, Research & Experimental

Multifunctional Nanocomposites Based on Liposomes and Layered Double Hydroxides Conjugated with Glycylsarcosine for Efficient Topical Drug Delivery to the Posterior Segment of the Eye

Yan Gu et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Medicine, Research & Experimental

Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model

Juliana de Oliveira Silva et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Nanoscience & Nanotechnology

Cancer Nanomedicine: A New Era of Successful Targeted Therapy

Mahmoud Zaki El-Readi et al.

JOURNAL OF NANOMATERIALS (2019)

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Article Chemistry, Medicinal

Glycol Chitosan-Docosahexaenoic Acid Liposomes for Drug Delivery: Synergistic Effect of Doxorubicin-Rapamycin in Drug-Resistant Breast Cancer

Min Woo Kim et al.

MARINE DRUGS (2019)

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Article Pharmacology & Pharmacy

Co-Encapsulation of Chlorin e6 and Chemotherapeutic Drugs in a PEGylated Liposome Enhance the Efficacy of Tumor Treatment: Pharmacokinetics and Therapeutic Efficacy

Po-Chun Peng et al.

PHARMACEUTICS (2019)

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Article Medicine, Research & Experimental

Investigation of the antitumor activity and toxicity of long-circulating and fusogenic liposomes co-encapsulating paclitaxel and doxorubicin in a murine breast cancer animal model

Marina Santiago Franco et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Chemistry, Medicinal

Codelivery of Adriamycin and P-gp Inhibitor Quercetin Using PEGylated Liposomes to Overcome Cancer Drug Resistance

Jiaqi Yu et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Chemistry, Applied

pH-sensitive and specific ligand-conjugated chitosan nanogels for efficient drug delivery

Lei Xing et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Instruments & Instrumentation

Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment

Alina Sesarman et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2019)

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Article Nanoscience & Nanotechnology

Engineering of Bone- and CD44-Dual-Targeting Redox-Sensitive Liposomes for the Treatment of Orthotopic Osteosarcoma

Shuaishuai Feng et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Nanoscience & Nanotechnology

Multifunctional Thermosensitive Liposomes Based on Natural Phase-Change Material: Near-Infrared Light-Triggered Drug Release and Multimodal Imaging-Guided Cancer Combination Therapy

Yeneng Dai et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Pharmacology & Pharmacy

Development of Long-Circulating and Fusogenic Liposomes Co-encapsulating Paclitaxel and Doxorubicin in Synergistic Ratio for the Treatment of Breast Cancer

Marjorie Coimbra Roque et al.

CURRENT DRUG DELIVERY (2019)

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Article Materials Science, Biomaterials

Magnetic liposomes for light-sensitive drug delivery and combined photothermal-chemotherapy of tumors

Song Shen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Nanoscience & Nanotechnology

Anti-MUC1/CD44 Dual-Aptamer-Conjugated Liposomes for Cotargeting Breast Cancer Cells and Cancer Stem Cells

Dong-Min Kim et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Biochemistry & Molecular Biology

Endosomal escape by photo-activated fusion of liposomes containing a malachite green derivative: a novel class of photoresponsive liposomes for drug delivery vehicles

Keita Hayashi et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2019)

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Article Oncology

Targeting nucleolin for better survival in diffuse large B-cell lymphoma

N. Jain et al.

LEUKEMIA (2018)

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Article Engineering, Biomedical

Layer-by-layer assembly of graphene oxide on thermosensitive liposomes for photo-chemotherapy

Mohadeseh Hashemi et al.

ACTA BIOMATERIALIA (2018)

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Article Biophysics

pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells

Yuqiong Xia et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Review Oncology

Meeting the needs of breast cancer: A nucleolin's perspective

Ana C. Gregorio et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)

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Article Pharmacology & Pharmacy

Transferrin and octaarginine modified dual-functional liposomes with improved cancer cell targeting and enhanced intracellular delivery for the treatment of ovarian cancer

Pranali Deshpande et al.

DRUG DELIVERY (2018)

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Article Pharmacology & Pharmacy

Selenium-functionalized liposomes for systemic delivery of doxorubicin with enhanced pharmacokinetics and anticancer effect

Qian Xie et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

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Article Biochemistry & Molecular Biology

Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein

Hafizah Mahmud et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Pharmacology & Pharmacy

Dual-effect liposomes with increased antitumor effects against 67-kDa laminin receptor-overexpressing tumor cells

Ikumi Sugiyama et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Chemistry, Multidisciplinary

A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic-chemo therapy system

Qingpo Li et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Biochemistry & Molecular Biology

Liposomes-Camouflaged Redox-Responsive Nanogels to Resolve the Dilemma between Extracellular Stability and Intracellular Drug Release

Jinfeng Ma et al.

MACROMOLECULAR BIOSCIENCE (2018)

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Article Oncology

Selective Targeting and Eradication of LGR5+ thorn Cancer Stem Cells Using RSPO-Conjugated Doxorubicin Liposomes

Jing Cao et al.

MOLECULAR CANCER THERAPEUTICS (2018)

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Article Nanoscience & Nanotechnology

Doxorubicin/gold nanoparticles coated with liposomes for chemo-photothermal synergetic antitumor therapy

Shanshan Xing et al.

NANOTECHNOLOGY (2018)

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Article Pharmacology & Pharmacy

Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes co-encapsulating curcumin and doxorubicin on C26 murine colon cancer cells

Alina Sesarman et al.

PHARMACOLOGICAL REPORTS (2018)

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Article Chemistry, Medicinal

Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation

Shizheng Li et al.

PHYTOTHERAPY RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

Ultrasonically controlled estrone-modified liposomes for estrogen-positive breast cancer therapy

Najla M. Salkho et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Chemistry, Multidisciplinary

The comparative effect of wrapping solid gold nanoparticles and hollow gold nanoparticles with doxorubicin-loaded thermosensitive liposomes for cancer thermo-chemotherapy

Yanan Li et al.

NANOSCALE (2018)

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Article Multidisciplinary Sciences

Chemo-immunotherapy of colon cancer with focused ultrasound and Salmonella-laden temperature sensitive liposomes (thermobots)

Kalyani Ektate et al.

SCIENTIFIC REPORTS (2018)

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Review Immunology

Immunomodulation of the Tumor Microenvironment: Turn Foe Into Friend

Hanne Locy et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Engineering, Biomedical

MRI analysis to map interstitial flow in the brain tumor microenvironment

Kathryn M. Kingsmore et al.

APL BIOENGINEERING (2018)

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Article Pharmacology & Pharmacy

Formulation and Optimization of Doxorubicin and Biochanin A Combinational Liposomes for Reversal of Chemoresistance

Tapan K. Dash et al.

AAPS PHARMSCITECH (2017)

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Article Biochemistry & Molecular Biology

Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition

Menghua Gao et al.

JOURNAL OF LIPOSOME RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Reversal of P-glycoprotein-mediated multidrug resistance by doxorubicin and quinine co-loaded liposomes in tumor cells

Qiying Shen et al.

JOURNAL OF LIPOSOME RESEARCH (2017)

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Article Engineering, Biomedical

Glioma targeted delivery strategy of doxorubicin-loaded liposomes by dual-ligand modification

Wei Han et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2017)

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Article Chemistry, Multidisciplinary

Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models

Yingying Chi et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Oncology

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

Wanpei Cai et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Biotechnology & Applied Microbiology

Doxorubicin-loaded liposomes: enhancing the oral bioavailability by modulation of physicochemical characteristics

Marjan Daeihamed et al.

NANOMEDICINE (2017)

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Article Chemistry, Medicinal

In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors

Yuan Ding et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

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Article Chemistry, Medicinal

Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach

Lucia Ruxandra Tefas et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

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Article Oncology

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

Xiaoyun Dai et al.

ONCOTARGET (2017)

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Review Oncology

Role of tumor microenvironment in tumorigenesis

Maonan Wang et al.

JOURNAL OF CANCER (2017)

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Review Oncology

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

Wanpei Cai et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Oncology

MiR-101 and doxorubicin codelivered by liposomes suppressing malignant properties of hepatocellular carcinoma

Fei Xu et al.

CANCER MEDICINE (2017)

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Article Medicine, Research & Experimental

MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma

Yin-Ping Fan et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

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Article Multidisciplinary Sciences

Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients

Virginie Marcel et al.

PLOS ONE (2017)

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Review Pharmacology & Pharmacy

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Behzad Mansoori et al.

ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Article Pharmacology & Pharmacy

Cancer cell and macrophage cross-talk in the tumor microenvironment

Nathalie Dehnel et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

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Article Chemistry, Multidisciplinary

Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy

Xue-jia Kang et al.

ACTA PHARMACOLOGICA SINICA (2017)

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Review Oncology

Surgery for Cancer: A Trigger for Metastases

Samer Tohme et al.

CANCER RESEARCH (2017)

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Article Nanoscience & Nanotechnology

Peptide-22 and Cyclic RGD Functionalized Liposomes for Glioma Targeting Drug Delivery Overcoming BBB and BBTB

Cuitian Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Nanoscience & Nanotechnology

Coadministration of Oligomeric Hyaluronic Acid-Modified Liposomes with Tumor-Penetrating Peptide-iRGD Enhances the Antitumor Efficacy of Doxorubicin against Melanoma

Caifeng Deng et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Pharmacology & Pharmacy

Targeted delivery of transferrin and TAT co-modified liposomes encapsulating both paclitaxel and doxorubicin for melanoma

Mingqing Yuan et al.

DRUG DELIVERY (2016)

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Article Oncology

Nucleolin overexpression is associated with an unfavorable outcome for ependymoma: a multifactorial analysis of 176 patients

Chunjui Chen et al.

JOURNAL OF NEURO-ONCOLOGY (2016)

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Article Biochemistry & Molecular Biology

Lipid rafts-mediated endocytosis and physiology-based cell membrane traffic models of doxorubicin liposomes

Yinghuan Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

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Article Engineering, Biomedical

Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release

Dandan Luo et al.

BIOMATERIALS (2016)

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Review Cell Biology

The Emerging Hallmarks of Cancer Metabolism

Natalya N. Pavlova et al.

CELL METABOLISM (2016)

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Article Biophysics

Doxorubicin-loaded photosensitive magnetic liposomes for multi-modal cancer therapy

Saqlain A. Shah et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Article Biophysics

EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery

Azadeh Haeri et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Article Biochemistry & Molecular Biology

Synergistic Combination of Doxorubicin and Paclitaxel Delivered by Blood Brain Barrier and Glioma Cells Dual Targeting Liposomes for Chemotherapy of Brain Glioma

Xiaoxiao Chen et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2016)

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Article Pharmacology & Pharmacy

Evaluation of the antitumor effect of dexamethasone palmitate and doxorubicin co-loaded liposomes modified with a sialic acid-octadecylamine conjugate

Jing Sun et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

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Article Pharmacology & Pharmacy

Anti-cancer activity of doxorubicin-loaded liposomes co-modified with transferrin and folic acid

Shravan Kumar Sriraman et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

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Article Chemistry, Multidisciplinary

Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity

Yang Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Oncology

Use of complementary and alternative medicine by patients with cancer: a cross-sectional study at different points of cancer care

J. Kleine Wortmann et al.

MEDICAL ONCOLOGY (2016)

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Article Oncology

Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma

Xiaoyun Dai et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Article Medicine, Research & Experimental

Enhanced Cytotoxicity of Folic Acid-Targeted Liposomes Co-Loaded with C6 Ceramide and Doxorubicin: In Vitro Evaluation on HeLa, A2780-ADR, and H69-AR Cells

Shravan Kumar Sriraman et al.

MOLECULAR PHARMACEUTICS (2016)

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Article Plant Sciences

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

Seung Ho Baek et al.

PHYTOMEDICINE (2016)

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Article Chemistry, Multidisciplinary

Rapid Light-Triggered Drug Release in Liposomes Containing Small Amounts of Unsaturated and Porphyrin-Phospholipids

Dandan Luo et al.

SMALL (2016)

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Article Oncology

RNF216 contributes to proliferation and migration of colorectal cancer via suppressing BECN1-dependent autophagy

Hui Wang et al.

ONCOTARGET (2016)

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Article Oncology

Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation

Fayun Zhang et al.

BREAST CANCER RESEARCH (2016)

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Review Chemistry, Multidisciplinary

Physical Principles of Nanoparticle Cellular Endocytosis

Sulin Zhang et al.

ACS NANO (2015)

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Article Chemistry, Multidisciplinary

Hexamodal Imaging with Porphyrin-Phospholipid-Coated Upconversion Nanoparticles

James Rieffel et al.

ADVANCED MATERIALS (2015)

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Review Biochemistry & Molecular Biology

The roles of nucleolin subcellular localization in cancer

Caroline Madeleine Berger et al.

BIOCHIMIE (2015)

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Article Engineering, Biomedical

Human epidermal growth factor receptor-2 antibodies enhance the specificity and anticancer activity of light-sensitive doxorubicin-labeled liposomes

Qingpo Li et al.

BIOMATERIALS (2015)

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Article Cell Biology

Centrosomal nucleolin is required for microtubule network organization

Xavier Gaume et al.

CELL CYCLE (2015)

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Article Chemistry, Physical

Oxide-Free Gadolinium Nanocrystals with Large Magnetic Moments

Yavuz N. Ertas et al.

CHEMISTRY OF MATERIALS (2015)

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Article Food Science & Technology

Inverse relationship between elemental selenium nanoparticle size and inhibition of cancer cell growth in vitro and in vivo

Yijun Wang et al.

FOOD AND CHEMICAL TOXICOLOGY (2015)

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Article Chemistry, Multidisciplinary

Porphyrin-phospholipid liposomes with tunable leakiness

Dandan Luo et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Novel Galactosylated Poly(ethylene glycol)-Cholesterol for Liposomes as a Drug Carrier for Hepatocyte-Targeting

Huafang Zhang et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2015)

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Article Dermatology

Dual-Effect Liposomes Encapsulated With Doxorubicin and Chlorin e6 Augment the Therapeutic Effect of Tumor Treatment

Po-Chun Peng et al.

LASERS IN SURGERY AND MEDICINE (2015)

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Article Chemistry, Multidisciplinary

Functionalization of cobalt porphyrin-phospholipid bilayers with his-tagged ligands and antigens

Shuai Shao et al.

NATURE CHEMISTRY (2015)

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Review Chemistry, Multidisciplinary

Recent Advances in Higher-Order, Multimodal, Biomedical Imaging Agents

James Rieffel et al.

SMALL (2015)

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Article Oncology

The evolution of cancer surgery and future perspectives

Lynda Wyld et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

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Article Engineering, Biomedical

Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated RGDK-lipopeptide to tumor vasculature

Sugata Barui et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

PEGylated liposomes with NGR ligand and heat-activable cell-penetrating peptide-doxorubicin conjugate for tumor-specific therapy

Yanfang Yang et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

Combined mTOR inhibitor rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin α3 in triple-negative breast cancer

Wenbing Dai et al.

BIOMATERIALS (2014)

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Article Engineering, Biomedical

Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy

Defu Cai et al.

BIOMATERIALS (2014)

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Article Nanoscience & Nanotechnology

The co-delivery of a low-dose P-glycoprotein inhibitor with doxorubicin sterically stabilized liposomes against breast cancer with low P-glycoprotein expression

Wei Gao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

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Article Nanoscience & Nanotechnology

GE11-modified liposomes for non-small cell lung cancer targeting: preparation, ex vitro and in vivo evaluation

Liang Cheng et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

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Article Pharmacology & Pharmacy

Liposomes for targeting hepatocellular carcinoma: Use of conjugated arabinogalactan as targeting ligand

Sanket M. Shah et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Medicine, Research & Experimental

Synergistic Dual-Ligand Doxorubicin Liposomes Improve Targeting and Therapeutic Efficacy of Brain Glioma in Animals

Taili Zong et al.

MOLECULAR PHARMACEUTICS (2014)

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Article Multidisciplinary Sciences

Co-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy

Zhao Peng et al.

PLOS ONE (2014)

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Article Chemistry, Multidisciplinary

Folate and TAT Peptide Co-Modified Liposomes Exhibit Receptor-Dependent Highly Efficient Intracellular Transport of Payload In Vitro and In Vivo

Yaqin Zhu et al.

PHARMACEUTICAL RESEARCH (2014)

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Article Multidisciplinary Sciences

Porphyrin-phospholipid liposomes permeabilized by near-infrared light

Kevin A. Carter et al.

NATURE COMMUNICATIONS (2014)

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Article Medicine, Research & Experimental

Co-delivery of Doxorubicin and Bmi 1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo

Tan Yang et al.

THERANOSTICS (2014)

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Article Immunology

Overexpression of nucleolin and different expression sites both related to the prognosis of gastric cancer

Wensheng Qiu et al.

APMIS (2013)

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Article Nanoscience & Nanotechnology

Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo

Vadzim Reshetov et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

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Article Nanoscience & Nanotechnology

Tumor-penetrating peptide functionalization enhances the anti-glioblastoma effect of doxorubicin liposomes

Yiyi Yang et al.

NANOTECHNOLOGY (2013)

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Review Instruments & Instrumentation

Questioning the use of PEGylation for drug delivery

Johan J. F. Verhoef et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2013)

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Article Chemistry, Multidisciplinary

Selenium Nanoparticles as a Carrier of 5-Fluorouracil to Achieve Anticancer Synergism

Wen Liu et al.

ACS NANO (2012)

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Review Biochemistry & Molecular Biology

Roles for Actin Assembly in Endocytosis

Olivia L. Mooren et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

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Article Chemistry, Inorganic & Nuclear

Positive Surface Charge Enhances Selective Cellular Uptake and Anticancer Efficacy of Selenium Nanoparticles

Bo Yu et al.

INORGANIC CHEMISTRY (2012)

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Review Pathology

Neuropilins: expression and roles in the epithelium

Jonathan R. L. Wild et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2012)

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Review Medicine, General & Internal

Cancer and Radiation Therapy: Current Advances and Future Directions

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INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2012)

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Article Pharmacology & Pharmacy

Intracellular delivery of redox cycler-doxorubicin to the mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes

Sarandeep Singh Malhi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Chemistry, Multidisciplinary

Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity

Erez Koren et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Biochemistry & Molecular Biology

Doxorubicin and chloroquine coencapsulated liposomes: preparation and improved cytotoxicity on human breast cancer cells

Liyan Qiu et al.

JOURNAL OF LIPOSOME RESEARCH (2012)

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Article Materials Science, Multidisciplinary

Thermo-responsive copolymer coated MnFe2O4 magnetic nanoparticles for hyperthermia therapy and controlled drug delivery

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MATERIALS CHEMISTRY AND PHYSICS (2012)

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Review Pharmacology & Pharmacy

Liposomes and inorganic nanoparticles for drug delivery and cancer imaging

Carola Heneweer et al.

THERAPEUTIC DELIVERY (2012)

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Article Biochemistry & Molecular Biology

Binding of a C-End Rule Peptide to the Neuropilin-1 Receptor: A Molecular Modeling Approach

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BIOCHEMISTRY (2011)

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Article Pharmacology & Pharmacy

Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas

Huali Chen et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

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Article Chemistry, Physical

Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents

Jonathan F. Lovell et al.

NATURE MATERIALS (2011)

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Review Biochemistry & Molecular Biology

Virus Entry by Endocytosis

Jason Mercer et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)

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Review Pharmacology & Pharmacy

Recent Advances in Cancer Therapy: An Overview

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CURRENT PHARMACEUTICAL DESIGN (2010)

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Review Pharmacology & Pharmacy

Liposomal cancer therapy: exploiting tumor characteristics

Thomas Kaasgaard et al.

EXPERT OPINION ON DRUG DELIVERY (2010)

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Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy

Kannan M. Krishnan

IEEE TRANSACTIONS ON MAGNETICS (2010)

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Article Pharmacology & Pharmacy

Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake

Kazuhiro Takara et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Pharmacology & Pharmacy

PHSCNK-Modified and doxorubicin-loaded liposomes as a dual targeting system to integrin-overexpressing tumor neovasculature and tumor cells

Wenbing Dai et al.

JOURNAL OF DRUG TARGETING (2010)

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Article Medicine, Research & Experimental

Efficient Delivery of Payload into Tumor Cells in a Controlled Manner by TAT and Thiolytic Cleavable PEG Co-Modified Liposomes

Rui Kuai et al.

MOLECULAR PHARMACEUTICS (2010)

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Article Nanoscience & Nanotechnology

Octreotide-modification enhances the delivery and targeting of doxorubicin-loaded liposomes to somatostatin receptors expressing tumor in vitro and in vivo

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NANOTECHNOLOGY (2010)

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Article Oncology

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

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CANCER CELL (2009)

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Disaccharide-modified liposomes and their in vitro intracellular uptake

Chung Kil Song et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)

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Article Pharmacology & Pharmacy

Targeted delivery of doxorubicin using stealth liposomes modified with transferrin

XueMing Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)

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Article Multidisciplinary Sciences

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Pharmacology & Pharmacy

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

Yogeshkumar Malam et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

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Review Pharmacology & Pharmacy

Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers

Vladimir P. Torchilin

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Article Pharmacology & Pharmacy

Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes

Guangya Xiang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Review Cell Biology

Shaping cups into phagosomes and macropinosomes

Joel A. Swanson

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Article Pharmacology & Pharmacy

Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes

Hiroto Hatakeyama et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

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Article Biochemistry & Molecular Biology

Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication

Iva Ugrinova et al.

BMC MOLECULAR BIOLOGY (2007)

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Review Oncology

Neuropilins in physiological and pathological angiogenesis

C. A. Staton et al.

JOURNAL OF PATHOLOGY (2007)

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Article Chemistry, Medicinal

Cholesterol as a bilayer anchor for PEGylation and targeting ligand in folate-receptor-targeted liposornes

Xiaobin B. Zhao et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

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Review Pharmacology & Pharmacy

pH-sensitive liposomes - principle and application in cancer therapy

H. Karanth et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2007)

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Article Pharmacology & Pharmacy

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer

Samah Anabousi et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)

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Review Biochemistry & Molecular Biology

Virus entry: Open sesame

M Marsh et al.

CELL (2006)

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Article Chemistry, Multidisciplinary

Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic

XB Xiong et al.

JOURNAL OF CONTROLLED RELEASE (2005)

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Review Chemistry, Medicinal

Folate receptor-mediated drug targeting: From therapeutics to diagnostics

AR Hilgenbrink et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2005)

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Article Chemistry, Medicinal

Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy:: In vitro and in vivo

XB Xiong et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2005)

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Article Pharmacology & Pharmacy

In vitro cytotoxicity of Stealth liposomes co-encapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells

JC Wang et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)

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Review Pharmacology & Pharmacy

Tat peptide-mediated cellular delivery:: back to basics

H Brooks et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

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Article Nutrition & Dietetics

Glutathione metabolism and its implications for health

GY Wu et al.

JOURNAL OF NUTRITION (2004)

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Review Biochemistry & Molecular Biology

The role of glutathione in cancer

GK Balendiran et al.

CELL BIOCHEMISTRY AND FUNCTION (2004)

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Article Biochemistry & Molecular Biology

OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis

MM Fretz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

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Article Biochemistry & Molecular Biology

Drug release rate influences the pharmacokinetics, biodistribution, therapeutic activity, and toxicity of pegylated liposomal doxorubicin formulations in murine breast cancer

GJR Charrois et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

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Article Biochemistry & Molecular Biology

Cellular uptake of the Tat peptide: an endocytosis mechanism following ionic interactions

E Vives

JOURNAL OF MOLECULAR RECOGNITION (2003)

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Article Biochemistry & Molecular Biology

Studies on the internalization mechanism of cationic cell-penetrating peptides

G Drin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Review Pharmacology & Pharmacy

Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway

ZM Qian et al.

PHARMACOLOGICAL REVIEWS (2002)

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Article Oncology

Lack of activity of stealth liposomal doxorubicin in the treatment of patients with anthracycline-resistant breast cancer

E Rivera et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2002)

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Review Oncology

Multidrug resistance in cancer: Role of ATP-dependent transporters

MM Gottesman et al.

NATURE REVIEWS CANCER (2002)

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Article Chemistry, Medicinal

Enhancement of gene transfer to cervical cancer cells using transferrin-conjugated liposome

SY Joo et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2002)

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Article Chemistry, Multidisciplinary

Efficiency of liposomes surface-modified with soybean-derived sterylglucoside as a liver targeting carrier in HepG2 cells

Y Maitani et al.

JOURNAL OF CONTROLLED RELEASE (2001)

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Review Biochemistry & Molecular Biology

Endocytosis and signaling cascades: a close encounter

V Cavalli et al.

FEBS LETTERS (2001)

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Review Biochemistry & Molecular Biology

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

FQ Schafer et al.

FREE RADICAL BIOLOGY AND MEDICINE (2001)

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