4.8 Review

Advances in microneedles research based on promoting hair regrowth

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Article Dermatology

Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway

Linlin Bao et al.

Summary: The study showed that microneedling combined with 5% minoxidil for treating AGA demonstrated superior therapeutic effects clinically, potentially by activating the Wnt/β-catenin signaling pathway to improve hair growth.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

Article Engineering, Biomedical

Minoxidil-loaded hyaluronic acid dissolving microneedles to alleviate hair loss in an alopecia animal model

Min Jae Kim et al.

Summary: Alopecia refers to hair loss in a specific part of the head, which can be caused by drugs, stress, and autoimmune disorders. This study investigates the use of hyaluronic acid (HA) in promoting hair dermal papilla (HDP) cell proliferation, migration, and aggregation to reduce hair loss in alopecia mice. The study also suggests the use of microneedles (MNs) as controlled drug delivery systems for better therapeutic effects and reduced side effects.

ACTA BIOMATERIALIA (2022)

Article Pharmacology & Pharmacy

Preparation, characterisation and comparison of glabridin-loaded hydrogel-forming microneedles by chemical and physical cross-linking

Xier Pan et al.

Summary: Poly(vinyl alcohol) (PVA) and carbomer were used as the hydrogel system to fabricate glabridin-loaded hydrogel-forming microneedles (HFMNs) using chemical cross-linking (CCMNs) and physical cross-linking (PCMNs). The results showed that CCMNs had better swelling and drug permeation properties compared to PCMNs.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Review Dermatology

Microneedling for Hair Loss

Aditya K. Gupta et al.

Summary: Microneedling is a relatively new therapeutic modality that shows promising results for treating various dermatological conditions, including hair loss. Studies found that microneedling as a monotherapy can significantly increase total hair count compared to topical minoxidil. Combination treatment of microneedling with minoxidil can further enhance the total hair count.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

Review Instruments & Instrumentation

Advances in microneedle-based transdermal delivery for drugs and peptides

Krishanu Aich et al.

Summary: Microneedles have been shown to enhance drug delivery and overcome the drawbacks of traditional injections, offering a significant opportunity for better clinical outcomes. Various types of microneedle designs, including solid, coated, hollow, and polymer microneedles, have been developed to improve drug delivery efficiency. Multiple studies are currently focusing on advancing formulation and microfabrication techniques for the delivery of protein drugs via microneedles.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Review Dermatology

Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

Yuanhong Liu et al.

Summary: This review provides an overview of recent research on alopecia, with a focus on hair follicle stem cell behavior and how metabolism, aging, and the microenvironment contribute to hair growth disorders. Understanding how dysregulated hair follicle stem cell behavior underlies alopecia can help identify potential therapeutic targets.

EXPERIMENTAL DERMATOLOGY (2022)

Review Dermatology

Current application of mesotherapy in pattern hair loss: A systematic review

Ziyuan Tang et al.

Summary: Mesotherapy has shown positive efficacy in treating pattern hair loss, with no significant side effects observed. However, the sample size is not large enough and there is insufficient research comparing mesotherapy to other treatments. Future studies are needed to provide more evidence.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

Review Immunology

Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implication of Post-Translational Modifications

Shahnawaz D. Jadeja et al.

Summary: Alopecia areata is a chronic disorder that causes unpredictable non-scarring hair loss. The exact factors that cause this disease in the hair follicles remain unclear, but changes in immune-competence and immune response to hair follicle-associated antigens are important factors. The identification of the hair follicle antigen(s) responsible for AA onset is challenging but essential for understanding the disease and developing effective treatments.

FRONTIERS IN IMMUNOLOGY (2022)

Review Pharmacology & Pharmacy

Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders

Yueting Gu et al.

Summary: Hair follicle-targeting drug delivery systems are a promising method for managing hair follicle-related dysfunctions, allowing for controlled drug release and enhanced therapeutic efficacy with minimal side effects.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Review Biochemistry & Molecular Biology

Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma as Regenerative Strategies

Pietro Gentile

Summary: The incidence of hair loss and telogen effluvium has increased in COVID-19 patients, possibly due to psychological stress, systemic inflammation, and oxidative stress. Reduced anagenic expression of proteoglycans may be a potential mechanism linking hair loss to COVID-19.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Chemistry, Multidisciplinary

Dissolving microneedles: Applications and growing therapeutic potential

Ziad Sartawi et al.

Summary: This review discusses the recent developments and trends of dissolving microneedles as a drug delivery system, highlighting their advantages over coated and hollow microneedles. It emphasizes the potential applications of dissolving microneedles in various therapeutic areas and addresses current trends in the microneedle landscape, including clinical trials and commercial successes.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Plant Sciences

Exploring the effects of Chinese herbal ingredients on the signaling pathway of alopecia and the screening of effective Chinese herbal compounds

Jinjin Dou et al.

Summary: This study collected experimental research results related to alopecia and screened effective herbal combinations. The results showed that some herbal combinations appeared frequently and were closely related to vascular drugs. This study further elucidated the therapeutic mechanisms of herbs and compounds for alopecia and provided higher quality evidence for the treatment of alopecia.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Review Engineering, Biomedical

Flexible polymeric patch based nanotherapeutics against non-cancer therapy

Houjuan Zhu et al.

Summary: Flexible polymeric patches have wide applications in biomedicine due to their biological and tunable features. The combination of nanomaterials with polymeric patches can improve curative efficacy and reduce systemic toxicity. This review briefly presents the classification and advantages of flexible polymeric patches integrated with nanomaterials, and systematically reviews their applications in non-cancerous diseases. The limitations, challenges, and future perspectives of these biomedical therapeutic devices are also discussed.

BIOACTIVE MATERIALS (2022)

Article Multidisciplinary Sciences

ROR2 regulates self-renewal and maintenance of hair follicle stem cells

Anthony Veltri et al.

Summary: The study reveals the important roles of the Wnt receptor ROR2 in the activation, self-renewal, and maintenance of hair follicle stem cells (HFSCs), through both transducing Wnt signaling and regulating DNA damage response.

NATURE COMMUNICATIONS (2022)

Article Engineering, Biomedical

A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

Yan Shi et al.

Summary: A painless and side-effect-free treatment for hair loss has been developed using a microneedle patch. The patch activates dermal papilla cells to promote hair regeneration and has shown better efficacy and lower dosing frequency compared to traditional treatments. Its inherent antibacterial properties make it a safe option for clinical application.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Pharmacology & Pharmacy

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Yali Lin et al.

Summary: Interest in transdermal delivery methods for stimulating hair regrowth has been increasing recently. The microneedle approach can improve drug delivery efficiency by puncturing the barrier of the stratum corneum. In this study, a dissolvable microneedle device was developed for co-delivery of rapamycin and epigallocatechin gallate nanoparticles, which showed significant promotion of hair regeneration.

PHARMACEUTICS (2022)

Article Chemistry, Multidisciplinary

Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis

Anran Yuan et al.

Summary: This study developed a new treatment approach for androgenetic alopecia (AGA) by using a dissolvable microneedles (MNs) patch loaded with conditioned media derived from hypoxia-pretreated mesenchymal stem cells. The results showed that this approach successfully increased perifollicular vascularization, activated hair follicle stem cells, and promoted hair regeneration.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Immunology

An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

Maddison Lensing et al.

Summary: Alopecia Areata (AA) is a common autoimmune disease characterized by hair loss. The breakdown of immune privilege of the hair follicle plays a role in the development of the disease. IFN gamma and other cytokines are involved in the pathogenesis of AA. Targeting the JAK/STAT signaling pathways has been shown to be effective in treating the disease.

FRONTIERS IN IMMUNOLOGY (2022)

Review Pharmacology & Pharmacy

Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems

Jitong Wang et al.

Summary: Arthritis refers to a group of inflammatory joint diseases that severely limit patients' mobility. Rheumatoid arthritis and osteoarthritis, affecting more than 4% of the global population, are the most common clinical conditions. Conventional medication for arthritis often causes gastrointestinal side effects and inconvenience. In recent years, microneedle technology has provided a new approach for transdermal delivery of arthritis drugs with its painless skin perforation and efficient local delivery advantages. This review summarizes different types of arthritis and current therapeutic agents, highlights the development of microneedles in arthritis drug delivery, and discusses the challenges of translating this technology into clinical practice and the marketplace.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment

Youseong Kim et al.

Summary: Researchers have developed a specially shaped dissolving microneedle (DMN) and a novel drug called M119 for the treatment of alopecia. In vitro and ex vivo studies have demonstrated enhanced hair follicle targeting drug delivery and superior efficacy in alopecia treatment.

ADVANCED THERAPEUTICS (2022)

Review Instruments & Instrumentation

Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy

Vahid Alimardani et al.

Summary: Microneedles arrays (MNs) have been introduced as a novel, minimally invasive, and low-cost approach to deliver drugs to tumor tissues in a safe and controlled manner. They have promising potential in cancer therapy applications.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Article Pharmacology & Pharmacy

Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays

Alvaro Carcamo-Martinez et al.

Summary: Autoimmune-mediated inflammatory skin diseases such as psoriasis, alopecia areata, and vitiligo can significantly impact patients' quality of life. Treatment with systemic steroids is common but may not always be successful. Recent studies have shown promising results with oral Janus Kinase (JAK) inhibitors, although they come with frequent side effects.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Microneedles mediated bioinspired lipid nanocarriers for targeted treatment of alopecia

Sisi Cao et al.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Medicine, General & Internal

Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

Vahid Alimardani et al.

Summary: Organic and inorganic nanoparticles have shown promising outcomes in transdermal drug delivery, but crossing the stratum corneum remains a challenge. Microneedle array technology has recently revealed promising outcomes in the delivery of various formulations, especially nanoparticles to deliver both hydrophilic and hydrophobic therapeutic agents.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Dermatology

Review article: Emerging issues in pediatric skin of color, part 1

Krystal N. Mitchell et al.

Summary: This article discusses important issues in the field of pediatric skin of color, including hair-related diseases, autoimmune issues, and infections.

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Building and Maintaining the Skin

Ya-Chieh Hsu et al.

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Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability

Yaling Deng et al.

Summary: The study focused on preparing cedrol nanoemulsion (CE-NE) to investigate its impact on hair growth and bioavailability. Results demonstrated the significant hair growth effects of CE-NE, along with improved drug solubility and bioavailability, suggesting enhanced therapeutic efficacy in vitro and in vivo.

MOLECULES (2021)

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Overview of Follicular Extraction

Anil Garg et al.

Summary: Follicular unit extraction (FUE), now known as follicular unit excision, is a method of harvesting hair follicles from the donor area for implantation in the recipient area. Different devices and punch types have been developed over the past 20 years, with various diameters for harvesting follicles. The extraction can be done manually or with motorized tools.

INDIAN JOURNAL OF PLASTIC SURGERY (2021)

Article Chemistry, Multidisciplinary

Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

Anran Yuan et al.

Summary: Androgenetic alopecia (AGA) is a common condition with oxidative stress and insufficient vascularization as main causes. A novel Ce-MNs patch was designed to alleviate oxidative stress and promote angiogenesis, reshaping the perifollicular microenvironment for AGA treatment. The patch showed potential for safe and effective clinical use, accelerating hair regeneration in AGA mouse models compared to traditional treatment with minoxidil.

ACS NANO (2021)

Article Pharmacology & Pharmacy

Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

Alejandro J. Paredes et al.

Summary: The study developed long-acting dissolving and implantable PLGA MAPs for systemic release of FND for at least two weeks, using micromoulding methodology to obtain mechanically strong tip-loaded MAPs with pyramidal geometry. In vitro studies demonstrated that these patches could release the drug continuously, deposit a certain amount of FND in the skin, and gradually release it into the receptor compartment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Medicine, General & Internal

An Approach to Patients with Alopecia

Taylor A. Jamerson et al.

Summary: Hair loss is more than just a cosmetic issue, it can also be a sign of underlying systemic conditions. Comprehensive clinical evaluation and appropriate treatment are essential to address both patient dissatisfaction and the identification of medically significant conditions. A detailed patient history and physical examination play a key role in distinguishing between different forms of alopecia.

MEDICAL CLINICS OF NORTH AMERICA (2021)

Review Cell & Tissue Engineering

A systematic summary of survival and death signalling during the life of hair follicle stem cells

Xi-Min Hu et al.

Summary: Hair follicle stem cells (HFSCs) are valuable resources for studying adult stem cells and hair loss therapy, with potential therapeutic targets for skin and hair disorders. Multiple signaling pathways are involved in regulating the fate of HFSCs, providing a better understanding of pathophysiological changes in the HFSC niche.

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Long-acting microneedles: a progress report of the state-of-the-art techniques

Zhongjian Chen et al.

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Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Bu Young Choi

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Micro needling: A novel therapeutic approach for androgenetic alopecia, A Review of Literature

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Controlled drug delivery for alopecia: A review

Shefrin Salim et al.

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Alopecia as a systemic disease

Sonali Nanda et al.

CLINICS IN DERMATOLOGY (2019)

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Mesotherapy: Safety profile and management of complications

Kerasia-Maria Plachouri et al.

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Microneedles: A smart approach and increasing potential for transdermal drug delivery system

Tejashree Waghule et al.

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Transdermal Microneedles-A Materials Perspective

R. Ali et al.

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Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth

Shayan Fakhraei Lahiji et al.

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Overcoming or circumventing the stratum corneum barrier for efficient transcutaneous immunization

Zhongjian Chen et al.

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An appraisal of new treatment approaches and overview of current therapies

Lauren C. Strazzulla et al.

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Disease characteristics, clinical evaluation, and new perspectives on pathogenesis

Lauren C. Strazzulla et al.

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Medicinal Plants for the Treatment of Hair Loss and the Suggested Mechanisms

Yu-Li Shen et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

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Therapeutic Potential of Stem Cells in Follicle Regeneration

Agnieszka Owczarczyk-Saczonek et al.

STEM CELLS INTERNATIONAL (2018)

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The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis

Areej Adil et al.

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Alopecia areata

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Topically used herbal products for the treatment of hair loss: preclinical and clinical studies

Anna Herman et al.

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Review of applications of microneedling in dermatology

Christopher Iriarte et al.

CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY (2017)

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Androgenetic alopecia: a review

Francesca Lolli et al.

ENDOCRINE (2017)

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Low level laser therapy and hair regrowth: an evidence-based review

Mina Zarei et al.

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Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model

Yoon Seob Kim et al.

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Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis

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Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice ocr

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Innovative polymeric system (IPS) for solvent-free lipophilic drug transdermal delivery via dissolving microneedles

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Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1

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Effect of mycophenolic acid on proliferation of dermal papilla cells and induction of anagen hair follicles

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CLINICAL AND EXPERIMENTAL DERMATOLOGY (2015)

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The ginsenosides of Panax ginseng promote hair growth via similar mechanism of minoxidil

Su Na Kim et al.

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Transdermal Delivery of Drugs with Microneedles-Potential and Challenges

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Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration

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Promotion effect of constituents from the root of Polygonum multiflorum on hair growth

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Androgen actions on the human hair follicle: perspectives

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EXPERIMENTAL DERMATOLOGY (2013)

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Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery

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S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents

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BRITISH JOURNAL OF DERMATOLOGY (2011)

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Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla

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Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study

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Alopecia areata update Part I. Clinical picture, histopathology, and pathogenesis

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Cicatricial alopecia: classification and histopathology

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Determinants of marginal traction alopecia in African girls and women

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