Silk sericin as building blocks of bioactive materials for advanced therapeutics

Silk sericin is a class of protein biopolymers produced by silkworms. Increasing attention has been paid to silk sericin for biomedical applications in the last decade, not only because of its excellent biocompatibility and biodegradability but also due to the pharmacological activities stemming from its unique amino acid composi-tions. In this review, the biological properties of silk sericin, including curing specific diseases and promoting tissue regeneration, as well as underlying mechanisms are summarized. We consider the antioxidant activity of silk sericin as a fundamental property, which could account for partial biological activities, despite the exact mechanisms of silk sericin's effect remaining unknown. Based on the reactive groups on silk sericin, approaches of bottom-up fabrication of silk sericin-based biomaterials are highlighted, including non-covalent interactions and chemical reactions (reduction, crosslinking, bioconjugation, and polymerization). We then briefly present the cutting-edge advances of silk sericin-based biomaterials applied in tissue engineering and drug delivery. The challenges of silk sericin-based biomaterials are proposed. With more bioactivities and underlying mechanisms of silk sericin uncovered, it is going to boost the therapeutic potential of silk sericin-based biomaterials.

Automated summary

Silk sericin, produced by silkworms, has gained increasing attention in the field of biomedical applications due to its excellent biocompatibility, biodegradability, and pharmacological activities resulting from its unique amino acid compositions. This review summarizes the biological properties of silk sericin, including its potential in curing specific diseases, promoting tissue regeneration, and the underlying mechanisms. The antioxidant activity of silk sericin is considered a fundamental property, despite the exact mechanisms remaining unknown.