Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy

Article Medicine, Research & Experimental

Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy

Thuy Giang Nguyen Cao et al.

Summary: This study developed dual stimuli-responsive sonosensitizers using extracellular vesicles as carriers for safe and efficient chemo-sonodynamic combination cancer therapy and photoacoustic imaging.

THERANOSTICS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

A hypoxia-irrelevant Fe-doped multivalent manganese oxide sonosensitizer via a vacancy engineering strategy for enhanced sonodynamic therapy

Lina Sun et al.

Summary: This study developed a hypoxia-irrelevant sonosensitizer through vacancy engineering strategy, which effectively prevented the recombination of ROS and generated hypoxia-irrelevant singlet oxygen. The results demonstrated that vacancy engineering is a favorable method for constructing highly efficient and safe sonodynamic therapy.

NANO TODAY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy

Jiali Luo et al.

Summary: This study presents a promising approach to enhance immune response in cancer treatment by using cancer cell membrane-coated nano platforms, which promote immunogenic sonodynamic therapy and dendritic cell maturation simultaneously.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Yujie Liang et al.

Summary: This study developed a specific delivery vehicle for gene editing in chondrocytes to attenuate cartilage damage. The results showed that the hybrid delivery vehicle successfully delivered the gene plasmids and suppressed the expression of specific genes in chondrocytes, leading to a decrease in cartilage degradation. This research contributes to alleviating the symptoms and damage of osteoarthritis.

THERANOSTICS (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Precise Subcellular Organelle Targeting for Boosting Endogenous-Stimuli-Mediated Tumor Therapy

Wenyao Zhen et al.

Summary: Despite the significant progress in tumor therapies, limitations such as low penetration depth of laser, safety concerns of radiation, therapeutic resistance, and spatio-temporal constraints of specific equipment hinder their clinical applications. In addition, physiological barriers in the tumor microenvironment and the advantages of endogenous stimuli have driven the development of nanoplatforms and subcellular organelle-targeted strategies. These advancements may lead to improved precision medicine and clinical translation of multifunctional nanomedicines in the future.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Single Small Molecule-Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo

Kai Lin et al.

Summary: PQC NFs, composed of mitochondria-targeting small molecules with amphiphilicity, generate a significantly higher amount of reactive oxygen species in cells and induce intense apoptosis through mitochondrial disruption. These fiber-shaped nanomaterials also show long-term retention in tumor sites, achieving a 100% complete cure rate in cancer models with a single dose administration. This type of mitochondria-targeting nanofibers offers a promising strategy to enhance the therapeutic effects of conventional PDT in vivo.

ADVANCED FUNCTIONAL MATERIALS (2021)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Advances and perspectives in organic sonosensitizers for sonodynamic therapy

Xuejian Xing et al.

Summary: Sonodynamic therapy (SDT) is a promising minimally invasive approach for deep tumor treatment by combining low-intensity ultrasound (US) and a chemical sonosensitizer. Organic sonosensitizers have advantages like defined chemical structure and high ROS generation, but they often face challenges such as poor water solubility and low tumor targeting capacity. Strategies to improve these issues and combine SDT with other cancer treatments are discussed in this review.

COORDINATION CHEMISTRY REVIEWS (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Medicine, General & Internal

Single Step In Situ Detection of Surface Protein and MicroRNA in Clustered Extracellular Vesicles Using Flow Cytometry

Hee Cheol Yang et al.

Summary: A method for single step in situ detection of EV surface proteins and inner miRNAs using a flow cytometer was developed, allowing for the differentiation of cancer cell-derived EVs. This approach offers a simple, time- and labor-saving, non-invasive liquid biopsy method for diagnosing various diseases, including cancer.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Emerging Nanomedicine-Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

Hui Hu et al.

Summary: The rapid growth of nanomedicine and nanobiotechnology has enabled the emergence of distinctive disease-specific therapeutic modalities, specifically nanomedicine-enabled/augmented nanodynamic therapy (NDT). These modalities include different approaches such as sonodynamic therapy, thermodynamic therapy, electrodynamic therapy, and others, aiming to enhance disease-specific treatment with reduced side effects.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Safe and Targeted Sonodynamic Cancer Therapy Using Biocompatible Exosome-Based Nanosonosensitizers

Thuy Giang Nguyen Cao et al.

Summary: Utilizing exosomes as nanocarriers, this study effectively delivered the sonosensitizer ICG to tumor tissues, with surface modification using the cancer-targeting ligand FA to enhance ROS production in breast cancer cells and inhibit tumor growth. The active cancer-targeted FA-ExoICG showed superior tumor accumulation, pharmacokinetic properties, and sonotoxicity against cancer cells compared to ExoICG and free ICG, demonstrating its potential as an effective nanosonosensitizer for safe and targeted cancer treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Liquid exfoliation of TiN nanodots as novel sonosensitizers for photothermal-enhanced sonodynamic therapy against cancer

Xianwen Wang et al.

Summary: In this study, ultra-small titanium nitride nanodots were synthesized for photothermal-enhanced sonodynamic therapy against cancer. These nanodots exhibit promising multifunctional properties, combining the advantages of photothermal therapy and sonodynamic therapy for significant synergistic treatment effects on tumors. Importantly, these nanodots can be promptly metabolized from the body, reducing concerns about long-term toxicity.

NANO TODAY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Advanced biotechnology-assisted precise sonodynamic therapy

Yi Zhang et al.

Summary: The article discusses the advantages and potential of photodynamic therapy and sonodynamic therapy in the treatment of deep-seated tumors, as well as imaging-guided precise SDT and recent clinical trials. It also summarizes the strategies for designing sonosensitizers based on tumor environment and structure modifications, as well as the approach of SDT combination therapy.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation

Changwei Ji et al.

Summary: This study developed mitochondria-targeted nanoparticles to co-deliver oxygen and nitric oxide for enhancing sonodynamic therapy and reversing immunosuppression in the tumor microenvironment. The nanoparticles showed promising results in inhibiting tumor growth, promoting immunogenic cell death, and enhancing immune response both in vitro and in vivo. The findings provide a simple strategy to improve cancer immunotherapy by combining sonodynamic therapy with oxygen and nitric oxide delivery.

THERANOSTICS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Ultrasound-Activated Sensitizers and Applications

Xiahui Lin et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Extracellular vesicles as drug delivery systems: Why and how?

Omnia M. Elsharkasy et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultrafine Titanium Monoxide (TiO1+x) Nanorods for Enhanced Sonodynamic Therapy

Xianwen Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Nanoscience & Nanotechnology

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

Yujie Liang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Article Engineering, Biomedical

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

Jinchao Shen et al.

BIOMATERIALS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

Shubham Salunkhe et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Near-infrared triggered Ti3C2/g-C3N4 heterostructure for mitochondria-targeting multimode photodynamic therapy combined photothermal therapy

Yiyi Zhang et al.

NANO TODAY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications

Nan Song et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Article Engineering, Biomedical

Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

Kai Zhang et al.

BIOMATERIALS (2020)

添加到收藏夹

Review Oncology

The evolving translational potential of small extracellular vesicles in cancer

Andreas Moller et al.

NATURE REVIEWS CANCER (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Multifunctional sonosensitizers in sonodynamic cancer therapy

Subin Son et al.

CHEMICAL SOCIETY REVIEWS (2020)

添加到收藏夹

Article Oncology

Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems

Hui Wang et al.

CANCER LETTERS (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy

Qianhua Feng et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

添加到收藏夹

Review Engineering, Biomedical

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Wen Liao et al.

ACTA BIOMATERIALIA (2019)

添加到收藏夹

Review Acoustics

Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Maxime Lafond et al.

JOURNAL OF ULTRASOUND IN MEDICINE (2019)

添加到收藏夹

Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Mechanisms of Photosensitized Lipid Oxidation and Membrane Permeabilization

Isabel O. L. Bacellar et al.

ACS OMEGA (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Daniel E. Murphy et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Design strategies and application progress of therapeutic exosomes

Chunying Liu et al.

THERANOSTICS (2019)

添加到收藏夹

Article Chemistry, Physical

Ultrasound-triggered release of sinoporphyrin sodium from liposome-microbubble complexes and its enhanced sonodynamic toxicity in breast cancer

Yixiang Li et al.

NANO RESEARCH (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation

Piao Zhu et al.

ACS NANO (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Manufacturing Exosomes: A Promising Therapeutic Platform

Ivano Luigi Colao et al.

TRENDS IN MOLECULAR MEDICINE (2018)

添加到收藏夹

Review Medicine, Research & Experimental

Exosome Theranostics: Biology and Translational Medicine

Chuanjiang He et al.

THERANOSTICS (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Sophia G. Antimisiaris et al.

PHARMACEUTICS (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

David Rufino-Ramos et al.

JOURNAL OF CONTROLLED RELEASE (2017)

添加到收藏夹

Article Pharmacology & Pharmacy

Ultrasound triggered drug delivery for mitochondria targeted sonodynamic therapy

MengJia Chen et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Jacek Zielonka et al.

CHEMICAL REVIEWS (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Mercedes Tkach et al.

CELL (2016)

添加到收藏夹

Review Oncology

Recent advances of sonodynamic therapy in cancer treatment

Guo-Yun Wan et al.

CANCER BIOLOGY & MEDICINE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Binding and Fusion of Extracellular Vesicles to the Plasma Membrane of Their Cell Targets

Ilaria Prada et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

添加到收藏夹

Article Biophysics

Enhancement of indocyanine green stability and cellular uptake by incorporating cationic lipid into indocyanine green-loaded nanoemulsions

Eun-Hye Lee et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes

Susan M. Graham et al.

JOURNAL OF CONTROLLED RELEASE (2014)

添加到收藏夹

Article Oncology

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

Jong-Lyel Roh et al.

ONCOTARGET (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Challenges in design of translational nanocarriers

Qihang Sun et al.

JOURNAL OF CONTROLLED RELEASE (2012)

添加到收藏夹

Article Acoustics

Sonodynamically induced anti-tumor effect with protoporphyrin IX on hepatoma-22 solid tumor

Xiaobing Wang et al.

ULTRASONICS (2011)

添加到收藏夹

Article Oncology

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

Paul R. Lockman et al.

CLINICAL CANCER RESEARCH (2010)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Targeting mitochondria for cancer therapy

Simone Fulda et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

添加到收藏夹

Editorial Material Oncology

Chlorin e6-based photosensitizers for photodynamic therapy and photodiagnosis

Asta Juzeniene

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2009)

添加到收藏夹

Review Chemistry, Multidisciplinary

Targeting mitochondria

Adam T. Hoye et al.

ACCOUNTS OF CHEMICAL RESEARCH (2008)

添加到收藏夹

Article Chemistry, Multidisciplinary

Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes

Rebecca Notman et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

Evguenia Strom et al.

NATURE CHEMICAL BIOLOGY (2006)

添加到收藏夹

Review Pharmacology & Pharmacy

Mitochondria: a target for cancer therapy

JS Armstrong

BRITISH JOURNAL OF PHARMACOLOGY (2006)

添加到收藏夹

Review Oncology

A review of progress in clinical photodynamic therapy

Z Huang

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2005)

添加到收藏夹

Review Acoustics

Sonodynamic therapy - a review of the synergistic effects of drugs and ultrasound

I Rosenthal et al.

ULTRASONICS SONOCHEMISTRY (2004)

添加到收藏夹

Review Multidisciplinary Sciences

The pathophysiology of mitochondrial cell death

DR Green et al.

SCIENCE (2004)

添加到收藏夹

Review Biochemistry & Molecular Biology

Apoptotic pathways: Paper wraps stone blunts scissors

DR Green

CELL (2000)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

H Maeda et al.

JOURNAL OF CONTROLLED RELEASE (2000)

添加到收藏夹

Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy

相关参考文献

导出引文

分享论文