4.8 Article

Reversible covalent nanoassemblies for augmented nuclear drug translocation in drug resistance tumor

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JOURNAL OF CONTROLLED RELEASE
卷 353, 期 -, 页码 186-195

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ELSEVIER
DOI: 10.1016/j.jconrel.2022.11.031

关键词

Drug delivery; Phenylboronate; Nanoassemblies; Multidrug resistance

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In this study, reversible covalent nanoassemblies were synthesized for the delivery of DOX and TQR, which could overcome tumor MDR by improving nuclear drug accumulation. These nanoassemblies showed efficient tumor suppression efficacy in multidrug-resistant tumor models.
The drug efflux by P-glycoprotein (P-gp) is the primary contributor of multidrug resistance (MDR), which eventually generates insufficient nuclear drug accumulation and chemotherapy failure. In this paper, reversible covalent nanoassemblies on the basis of catechol-functionalized methoxy poly (ethylene glycol) (mPEG-dop) and phenylboronic acid-modified cholesterol (Chol-PBA) are successfully synthesized for delivery of both doxoru-bicin (DOX, anti-cancer drug) and tariquidar (TQR, P-glycoprotein inhibitor), which shows efficient nuclear DOX accumulation for overcoming tumor MDR. Through naturally forming phenylboronate linkage in physiological circumstances, Chol-PBA is able to bond with mPEG-dop. The resulting conjugates (PC) could self-assemble into reversible covalent nanoassemblies by dialysis method, and transmission electron microscopy analysis reveals the PC distributes in nano-scaled spherical particles before and after drug encapsulation. Under the assistance of Chol, PC can enter into lysosome of tumor cells via low-density lipoprotein (LDL) receptor-mediated endocytosis. Then the loaded TQR and DOX are released in acidic lysosomal compartments, which inhibit P-gp mediated efflux and elevate nuclear accumulation of DOX, respectively. At last, this drug loaded PC nanoassemblies show significant tumor suppression efficacy in multidrug-resistant tumor models, which suggests great potential for addressing MDR in cancer therapy.

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