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Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

JOURNAL OF CONTROLLED RELEASE (2023)

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Summary: This study investigated the antifungal activity, ocular irritation, and transport of fluconazole-loaded poly (epsilon-caprolactone) nanoparticles in a rabbit eye model. The optimized nanoparticles showed excellent antifungal activity, high drug entrapment efficiency, and were able to be successfully delivered to the eye using a thermosensitive in situ hydrogel, without causing irritation to the cornea.

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Pharmacokinetic and Pharmacodynamic Evaluation of Gemifloxacin Chitosan Nanoparticles As an Antibacterial Ocular Dosage Form

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Polyaphron Formulations Stabilised with Different Water-Soluble Polymers for Ocular Drug Delivery

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Nanosuspension as an Efficient Carrier for Improved Ocular Permeation of Voriconazole

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被撤回的出版物: Ofloxacin-Loaded Niosome-Laden Contact Lens: Improved Properties of Biomaterial for Ocular Drug Delivery (Retracted article. See vol. 23, 2022)

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Preparation and characterization of a naringenin solubilizing glycyrrhizin nanomicelle ophthalmic solution for experimental dry eye disease

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Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

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Summary: Topical drug delivery for eye therapy is challenging due to short retention time, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Various conventional and novel drug delivery systems, particularly nanosize carriers, have been developed to improve drug bioavailability and enhance therapeutic action for eye diseases. Promising results have been shown with drug-loaded nanoparticles for sustained drug release and improved efficacy in vitro and in vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

Dawin Khiev et al.

Summary: Nanotechnology plays a crucial role in treating ocular diseases by providing advantages such as sustained drug release and specific tissue targeting, as well as overcoming the blood-retinal barrier to increase drug bioavailability.

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Cyclosporine A Nanosuspensions for Ophthalmic Delivery: A Comparative Study between Cationic Nanoparticles and Drug-Core Mucus Penetrating Nanoparticles

Rong Yan et al.

Summary: The study compared the mucoadhesion of cationic nanoparticles and mucous permeability of MPPs on ocular bioavailability. Both cationic and MPP nanosuspensions showed effective delivery of CsA to anterior ocular tissues, with the cationic nanosuspension achieving relatively higher bioavailability. The results suggest that cationic nanosuspension could be a promising ocular drug delivery system.

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Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants

Ana R. Fernandes et al.

Summary: This article discusses the potential of nanoemulsions as delivery systems for ocular drug administration, emphasizing on factors such as lipid composition and types of surfactants, and the importance of manufacturing techniques and characterization methods for the development of suitable ophthalmic nanoemulsions to increase patient compliance.

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Article Pharmacology & Pharmacy

Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System (ODDS) for Cyclosporine-A

Eleonora Terreni et al.

Summary: This study explored the potential of a combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier as a new Ocular Drug Delivery System for Cyclosporine-A. By optimizing the physical-chemical characterization of the nanomicelles and incorporating them into ion-sensitive polymeric dispersions, the system showed improved ocular bioavailability of CyA and reduced cytotoxicity. This new approach prevented CyA transcorneal permeation and extended its resident time in the precorneal area, showing promise for future ocular drug delivery systems.

PHARMACEUTICS (2021)

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Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: Penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility

Baohuan Wu et al.

Summary: This study successfully designed a TAT-Lip system that can promote corneal drug delivery, and its effectiveness was confirmed through in vitro and in vivo experiments, effectively reducing drug loss rate and demonstrating good anti-inflammatory effects in animal models.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation

Ana Lopez-Machado et al.

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Novel Chitosan-Coated Niosomal Formulation for Improved Management of Bacterial Conjunctivitis: A Highly Permeable and Efficient Ocular Nanocarrier for Azithromycin

Hussein M. Eid et al.

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Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Elisa Toropainen et al.

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Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies

Mohammad Mofidfar et al.

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Deepika Modi et al.

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Agnieszka Gawin-Mikolajewicz et al.

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Mohammad Tavakoli et al.

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Brinzolamide-loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests

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In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies

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In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery

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New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment

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Improving the topical ocular pharmacokinetics of lyophilized cyclosporine A-loaded micelles: formulation, in vitro and in vivo studies

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Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Cell penetrating peptides in ocular drug delivery: State of the art

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MOLECULAR PHARMACEUTICS (2018)

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POLYMERS (2018)

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Ophthalmic Drug Delivery Systems for Antibiotherapy-A Review

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PHARMACEUTICS (2018)

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Ocular Drug Delivery Barriers-Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

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Encapsulation of Azithromycin Ion Pair in Liposome for Enhancing Ocular Delivery and Therapeutic Efficacy on Dry Eye

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Gelatin-epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief

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PHARMACEUTICAL RESEARCH (2018)

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Ocular amphotericin B delivery by chitosan-modified nanostructured lipid carriers for fungal keratitis-targeted therapy

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Studying the influence of formulation and process variables on Vancomycin-loaded polymeric nanoparticles as potential carrier for enhanced ophthalmic delivery

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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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EXPERT REVIEW OF PROTEOMICS (2017)

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Designing lipid nanoparticles for topical ocular drug delivery

Jesus Alvarez-Trabado et al.

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The effect of particle shape on cellular interaction and drug delivery applications of micro-and nanoparticles

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model

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Antibody-Conjugated, DNA-Based Nanocarriers Intercalated with Doxorubicin Eliminate Myofibroblasts in Explants of Human Lens Tissue

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MOLECULAR PHARMACEUTICS (2017)

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TFOS DEWS II Definition and Classification Report

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OCULAR SURFACE (2017)

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LANCET GLOBAL HEALTH (2017)

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Fast Dissolving Dendrimer Nanofiber Mats as Alternative to Eye Drops for More Efficient Antiglaucoma Drug Delivery

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Fast Dissolving Dendrimer Nanofiber Mats as Alternative to Eye Drops for More Efficient Antiglaucoma Drug Delivery

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Nanotechnology-based strategies for treatment of ocular disease

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ACTA PHARMACEUTICA SINICA B (2017)

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CANADIAN JOURNAL OF CHEMISTRY (2017)

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Development of Timolol-Loaded Galactosylated Chitosan Nanoparticles and Evaluation of Their Potential for Ocular Drug Delivery

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AAPS PHARMSCITECH (2017)

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Synthesis and evaluation of mucoadhesive acryloyl-quaternized PDMAEMA nanogels for ocular drug delivery

Ruairi P. Brannigan et al.

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In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration

H. O. Ammar et al.

DRUG DELIVERY (2017)

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Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

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Preparation and evaluation of naringenin-loaded sulfobutylether-β-cyclodextrinichitosan nanoparticles for ocular drug delivery

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Hyaluronic acid-coated niosomes facilitate tacrolimus ocular delivery: Mucoadhesion, precorneal retention, aqueous humor pharmacokinetics, and transcorneal permeability

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PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization

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Improving the topical ocular pharmacokinetics of an immunosuppressant agent with mucoadhesive nanoemulsions: Formulation development, in-vitro and in-vivo studies

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Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole

Rakesh Kumar et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2016)

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Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis

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MOLECULAR PHARMACEUTICS (2016)

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Novel Water-Soluble Mucoadhesive Carbosilane Dendrimers for Ocular Administration

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MOLECULAR PHARMACEUTICS (2016)

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Chitosan Nanolayered Cisplatin-Loaded Lipid Nanoparticles for Enhanced Anticancer Efficacy in Cervical Cancer

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NANOSCALE RESEARCH LETTERS (2016)

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Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery

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JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Chitosan Nanolayered Cisplatin-Loaded Lipid Nanoparticles for Enhanced Anticancer Efficacy in Cervical Cancer

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NANOSCALE RESEARCH LETTERS (2016)

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The Effect of Silica Nanoparticles on Human Corneal Epithelial Cells

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SCIENTIFIC REPORTS (2016)

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Development and Evaluation of Diclofenac Sodium Loaded-N-Trimethyl Chitosan Nanoparticles for Ophthalmic Use

Rathapon Asasutjarit et al.

AAPS PHARMSCITECH (2015)

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Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy

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ACS NANO (2015)

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Nanotherapies for the treatment of ocular diseases

S. Reimondez-Troitino et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Undefined role of mucus as a barrier in ocular drug delivery

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Dexamethasone nanowafer as an effective therapy for dry eye disease

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Shape effect in cellular uptake of PEGylated nanoparticles: comparison between sphere, rod, cube and disk

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NANOSCALE (2015)

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An Update on Ocular Surface Epithelial Stem Cells: Cornea and Conjunctiva

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STEM CELLS INTERNATIONAL (2015)

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Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac

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SCIENTIFIC REPORTS (2015)

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In vitro, in vivo and pharmacokinetic assessment of amikacin sulphate laden polymeric nanoparticles meant for controlled ocular drug delivery

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APPLIED NANOSCIENCE (2015)

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Preparation and in vitro-in vivo evaluation of ofioxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

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Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2014)

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Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity

Joana F. Fangueiro et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases

Paola Stephanie Apaolaza et al.

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Applications of Polymeric and Lipid Nanoparticles in Ophthalmic Pharmaceutical Formulations: Present and Future Considerations

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JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2014)

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On the Barrier Properties of the Cornea: A Microscopy Study of the Penetration of Fluorescent ly Labeled Nanoparticles, Polymers, and Sodium Fluorescein

Ellina A. Mun et al.

MOLECULAR PHARMACEUTICS (2014)

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One man's poison is another man's meat: Using azithromycin-induced phospholipidosis to promote ocular surface health

Yang Liu et al.

TOXICOLOGY (2014)

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Nanoparticle drug loading as a design parameter to improve docetaxel pharmacokinetics and efficacy

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BIOMATERIALS (2013)

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Recent advances in ocular drug delivery

Djamila Achouri et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2013)

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Review Medicine, General & Internal

Conjunctivitis A Systematic Review of Diagnosis and Treatment

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Enhanced Intrapulmonary Delivery of Anticancer siRNA for Lung Cancer Therapy Using Cationic Ethylphosphocholine-based Nanolipoplexes

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MOLECULAR THERAPY (2013)

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Review Nanoscience & Nanotechnology

Liposome: classification, preparation, and applications

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NANOSCALE RESEARCH LETTERS (2013)

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Expression of Efflux Transporters in Human Ocular Tissues

Peng Chen et al.

DRUG METABOLISM AND DISPOSITION (2013)

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Serious adverse events after cataract surgery

Joshua D. Stein

CURRENT OPINION IN OPHTHALMOLOGY (2012)

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Review Pharmacology & Pharmacy

In situ gel systems as 'smart' carriers for sustained ocular drug delivery

Ashish Kumar Agrawal et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

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Assessment of Ocular Pharmacokinetics and Safety of Ganciclovir Loaded Nanoformulations

Sohail Akhter et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2011)

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Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: Cellular toxicity, uptake, and kinetic studies

Pelin Aksungur et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Chemistry, Multidisciplinary

Shape Dependence of Gold Nanoparticles on In Vivo Acute Toxicological Effects and Biodistribution

Ya-Nan Sun et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2011)

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Article Chemistry, Medicinal

Potential Use of Nanostructured Lipid Carriers for Topical Delivery of Flurbiprofen

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JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

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Article Biochemistry & Molecular Biology

Advances in Mucoadhesion and Mucoadhesive Polymers

Vitaliy V. Khutoryanskiy

MACROMOLECULAR BIOSCIENCE (2011)

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Review Pharmacology & Pharmacy

Ocular Drug Delivery

Ripal Gaudana et al.

AAPS JOURNAL (2010)

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Article Chemistry, Multidisciplinary

Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability

Shun Han et al.

ACTA PHARMACOLOGICA SINICA (2010)

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Review Ophthalmology

Feasibility of Lipid Nanoparticles for Ocular Delivery of Anti-Inflammatory Drugs

Eliana B. Souto et al.

CURRENT EYE RESEARCH (2010)

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Article Chemistry, Medicinal

Designing dendrimers for ocular drug delivery

Gregory Spataro et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

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Tight junction modulation by chitosan nanoparticles: Comparison with chitosan solution

Driton Vllasaliu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Pharmacology & Pharmacy

Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability

Li Gan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Nanoscience & Nanotechnology

Development of Solid Lipid Nanoparticles for Enhanced Solubility of Poorly Soluble Drugs

Sriharsha Gupta Potta et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2010)

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Review Biotechnology & Applied Microbiology

Nanomicellar formulations for sustained drug delivery: strategies and underlying principles

Ruchit Trivedi et al.

NANOMEDICINE (2010)

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Review Pharmacology & Pharmacy

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

Samuel K. Lai et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

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Article Ophthalmology

Sustained Release and Permeation of Timolol from Surface-Modified Solid Lipid Nanoparticles through Bioengineered Human Cornea

A. A. Attama et al.

CURRENT EYE RESEARCH (2009)

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Review Chemistry, Multidisciplinary

Recent Perspectives in Ocular Drug Delivery

Ripal Gaudana et al.

PHARMACEUTICAL RESEARCH (2009)

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Article Biochemistry & Molecular Biology

Bioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue

M. de la Fuente et al.

GENE THERAPY (2008)

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Article Pharmacology & Pharmacy

Diclofenac sodium delivery to the eye:: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct

Anthony A. Attama et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Review Ophthalmology

When nanotechnology meets the ocular surface

Claudio Bucolo et al.

EXPERT REVIEW OF OPHTHALMOLOGY (2008)

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Article Biochemistry & Molecular Biology

Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude

Xioazhong Qu et al.

BIOMACROMOLECULES (2006)

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Review Pharmacology & Pharmacy

Topical and systemic drug delivery to the posterior segments

PM Hughes et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

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Review Ophthalmology

Determinants of eye drop size

L Van Santvliet et al.

SURVEY OF OPHTHALMOLOGY (2004)

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Review Pharmacology & Pharmacy

Vesicular systems in ocular drug delivery: an overview

IP Kaur et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)

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Review Engineering, Biomedical

Physico-chemical stability of colloidal lipid particles

B Heurtault et al.

BIOMATERIALS (2003)

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Article Ophthalmology

Molecular evidence and functional express ion of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines

S Dey et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)

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Review Chemistry, Medicinal

Penetration enhancers and ocular bioadhesives: Two new avenues for ophthalmic drug delivery

IP Kaur et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2002)

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Review Biochemistry & Molecular Biology

Keratitis

S Sharma

BIOSCIENCE REPORTS (2001)

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Review Pharmacology & Pharmacy

Solid lipid nanoparticles -: Production, characterization and applications

W Mehnert et al.

ADVANCED DRUG DELIVERY REVIEWS (2001)

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