期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 628, 期 -, 页码 273-286出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2022.07.168
关键词
Single -walled carbon nanohorns; Hyaluronic acid; Programmed phototherapy; Fluorescence imaging; Enzyme-responsive
资金
- National Natural Science Foundation of China [21977022, 21865005, 21671046]
- Guangxi Nat-ural Science Foundation of China [2022GXNSFAA035465]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2017-A08]
- Guangxi Technology Base and Talent Subject [GuikeAD19110159]
Phototheranostics is a precise treatment method that integrates light-based diagnostics and therapeutics, minimizing damage to normal tissues. In this study, a nanotheranostic agent, HA-IR808-SWNHs, was designed and synthesized, which can be employed to precisely track and ablate cancer cells in a spatiotemporal manner using an endogenous enzyme.
Phototheranostics, a local non-invasive approach that integrates light-based diagnostics and therapeu-tics, enables precise treatment using nanotheranostic agents with minimal damage to normal tissues. However, ensuring high-efficiency ablation of cancer cells using phototheranostics for one time irradia-tion is highly challenging. Herein, we designed and synthesized a single-walled carbon nanohorns-based nanotheranostic agent, HA-IR808-SWNHs, by loading IR808, a photosensitizer, conjugated hyaluronic acid (HA) with an amide bond on the surface of single-walled carbon nanohorns (SWNHs) through non -covalent p -p interaction by the sonication method. The HA in HA-IR808-SWNHs improves the water dis-persibility of SWNHs and endows SWNHs with targeting capabilities. Importantly, overexpressed endogenous hyaluronidase in cancer cells actively disassembles HA-IR808-SWNHs, forming small HA-IR808 fragments. The fragments exhibit a strong fluorescence signal and can be used to guide pro-grammed photodynamic therapy for sequentially eliminating the residual living cancer cells. The current study confirms that HA-IR808-SWNHs is an endogenous enzyme-responsive nanotheranostic agent that can be employed to precisely track and ablate residual cancer cells in a spatiotemporal manner. The results strengthen the understanding of SWNH functionalization and expand its potential biomedical application, especially in cancer theranostics. (c) 2022 Elsevier Inc. All rights reserved.
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