期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 50, 期 4, 页码 440-451出版社
WILEY
DOI: 10.1111/jcpe.13753
关键词
invasive fungal sinusitis; periodontitis; sinonasal fungal ball
The aim of this study was to investigate the effect of periodontitis on the incidence of fungal sinusitis. The study found that the risk of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS) increased after a diagnosis of periodontitis. Additionally, this trend was more severe in patients with diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), or chronic kidney disease (CKD).
Aim: The incidence of fungal sinusitis is increasing; however, its pathophysiology has not been investigated previously. We investigate the effect of periodontitis on the incidence of fungal sinusitis over a 12-year follow-up period using nationwide population-based data. Materials and Methods: The periodontitis group was randomly selected from the National Health Insurance Service database. The non-periodontitis group was obtained by propensity score matching considering several variables. The primary end point was the diagnosis of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS). Results: The periodontitis and non-periodontitis groups included 12,442 and 12,442 individuals, respectively. The overall adjusted hazard ratio (aHR) for SFBs in the periodontitis group was 1.46 (p = .002). In subgroup analysis, the aHR for SFBs was 1.59 (p = 0.008) for those with underlying chronic kidney disease (CKD), 1.58 (p = .022) for those with underlying atopic dermatitis, 1.48 (p = .019) for those with chronic obstructive pulmonary disease (COPD), and 1.36 (p = .030) for those with diabetes mellitus (DM), but these values are applicable only when considering the relationship between periodontitis and SFB. The aHR for IFS in the periodontitis group was higher than in the non-periodontitis group (2.80; p = .004). Conclusions: The risk of SFBs and IFS increased after diagnosis of periodontitis. This trend is often more severe in patients with DM, COPD, or CKD, but this association with underlying diseases is applicable only when considering the association between periodontitis and fungal sinusitis.
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