4.7 Article

Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis

Yunqi Liu et al.

Summary: This study found that the Slit2-Robo1 signaling pathway is involved in cardiac fibrosis and interferes with the TGF-beta 1/Smad pathway. Blocking Slit2-Robo1 may be a new treatment approach for cardiac fibrosis.

ESC HEART FAILURE (2021)

Review Genetics & Heredity

Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis

Jan M. Leerink et al.

Summary: In anthracycline-induced cardiomyopathy, ECM remodeling plays a crucial role. A review of 68 studies in various animal models revealed differential expression of 29 proteins and 11 mRNAs related to ECM remodeling pathways. Upregulation of collagens, MMPs, inflammation markers, TGF-β signaling markers, and markers for cardiac hypertrophy, along with downregulation of the AKT pro-survival pathway, were observed in this type of cardiomyopathy.

JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

Article Cardiac & Cardiovascular Systems

Reactive fibrosis precedes doxorubicin-induced heart failure through sterile inflammation

Ryo Tanaka et al.

ESC HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Doxorubicin-Induced Myocardial Fibrosis Involves the Neurokinin-1 Receptor and Direct Effects on Cardiac Fibroblasts

Scott P. Levick et al.

HEART LUNG AND CIRCULATION (2019)

Review Cardiac & Cardiovascular Systems

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

Nikolaos G. Frangogiannis

CIRCULATION RESEARCH (2019)

Review Immunology

Mast Cells in Cardiac Fibrosis: New Insights Suggest Opportunities for Intervention

Stephanie A. Legere et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Slit-Robo signalling in heart development

Juanjuan Zhao et al.

CARDIOVASCULAR RESEARCH (2018)

Article Oncology

Prediction of Ischemic Heart Disease and Stroke in Survivors of Childhood Cancer

Eric J. Chow et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Cardiac fibrosis: new insights into the pathogenesis

Zhen-Guo Ma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Immunology

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure

Tania Nevers et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Genetics & Heredity

Loss of function in ROBO1 is associated with tetralogy of Fallot and septal defects

Paul Kruszka et al.

JOURNAL OF MEDICAL GENETICS (2017)

Article Medicine, General & Internal

Cardiac Outcomes in Adult Survivors of Childhood Cancer Exposed to Cardiotoxic Therapy A Cross-sectional Study

Daniel A. Mulrooney et al.

ANNALS OF INTERNAL MEDICINE (2016)

Review Cardiac & Cardiovascular Systems

Defining the Cardiac Fibroblast

Malina J. Ivey et al.

CIRCULATION JOURNAL (2016)

Article Cardiac & Cardiovascular Systems

The TGF-β pathway mediates doxorubicin effects on cardiac endothelial cells

Zuyue Sun et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves

Mathilda T. M. Mommersteeg et al.

CARDIOVASCULAR RESEARCH (2015)

Article Oncology

Individual Prediction of Heart Failure Among Childhood Cancer Survivors

Eric J. Chow et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Biochemical Research Methods

HTSeq-a Python framework to work with high-throughput sequencing data

Simon Anders et al.

BIOINFORMATICS (2015)

Review Biochemistry & Molecular Biology

The pathogenesis of cardiac fibrosis

Ping Kong et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Cardiac & Cardiovascular Systems

Slit-Roundabout Signaling Regulates the Development of the Cardiac Systemic Venous Return and Pericardium

Mathilda T. M. Mommersteeg et al.

CIRCULATION RESEARCH (2013)

Article Oncology

Modifiable Risk Factors and Major Cardiac Events Among Adult Survivors of Childhood Cancer

Gregory T. Armstrong et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Article Chemistry, Multidisciplinary

Chronic cardiotoxicity of doxorubicin involves activation of myocardial and circulating matrix metalloproteinases in rats

Monika Ivanova et al.

ACTA PHARMACOLOGICA SINICA (2012)

Review Cardiac & Cardiovascular Systems

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

Yanti Octavia et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)

Review Cardiac & Cardiovascular Systems

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart

Esther E. Creemers et al.

CARDIOVASCULAR RESEARCH (2011)

Article Physiology

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes

Malgorzata Tokarska-Schlattner et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2010)

Article Anatomy & Morphology

Expression of Slit and Robo Genes in the Developing Mouse Heart

Caroline Medioni et al.

DEVELOPMENTAL DYNAMICS (2010)

Article Cell Biology

Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation

Caroline Medioni et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Anthracycline associated cardiotoxicity in survivors of childhood cancer

Steven E. Lipshultz et al.

Article Genetics & Heredity

PLINK: A tool set for whole-genome association and population-based linkage analyses

Shaun Purcell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Article Cardiac & Cardiovascular Systems

Anthracycline cardiotoxicity in long-term survivors of childhood cancer

Rebecca E. Scully et al.

CARDIOVASCULAR TOXICOLOGY (2007)

Article Medicine, General & Internal

Chronic health conditions in adult survivors of childhood cancer

Kevin C. Oeffinger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Cardiac & Cardiovascular Systems

Transcriptional analysis of doxorubicin-induced cardiotoxicity

XM Yi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Slit and robo control cardiac cell polarity and morphogenesis

L Qian et al.

CURRENT BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Comparative recombination rates in the rat, mouse, and human genomes

MI Jensen-Seaman et al.

GENOME RESEARCH (2004)