☆ 4.6 Review

Persistent symptoms among post-COVID-19 survivors: A systematic review and meta-analysis

JOURNAL OF CLINICAL NURSING (2022)

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Summary: This study aimed to estimate the prevalence of persistent symptoms and signs at least 12 weeks after acute COVID-19 and found that a large proportion of patients experience post-acute COVID-19 syndrome 3 to 12 months after recovery from the acute phase of COVID-19. However, available studies of post-acute COVID-19 syndrome are highly heterogeneous. Future studies need to have appropriate comparator groups, standardized symptom definitions and measurements, and longer follow-up.

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Review Clinical Neurology

Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis

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Summary: Neurological and neuropsychiatric symptoms that persist or develop three months after the onset of COVID-19 pose a significant threat to the global healthcare system. A systematic review analyzed data from multiple studies and found that fatigue, cognitive dysfunction, and sleep disturbances were key features of post-COVID-19 syndrome. Psychiatric manifestations such as anxiety and depression were also common and increased in prevalence over time.

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Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation

Stephen J. Halpin et al.

Summary: This study is the first report from the United Kingdom on post-discharge symptoms in COVID-19 survivors, identifying fatigue, breathlessness, and psychological distress as common symptoms that require planning of rehabilitation services for appropriate management.

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Article Infectious Diseases

Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study

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Summary: The study described the common clinical sequelae in COVID-19 survivors discharged from the hospital for more than 3 months, including general symptoms, respiratory symptoms, cardiovascular-related symptoms, psychosocial symptoms, and alopecia. Female patients were more likely to experience physical decline/fatigue, postactivity polypnoea, and alopecia.

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Follow-up of adults with noncritical COVID-19 two months after symptom onset

Claudia Carvalho-Schneider et al.

Summary: In noncritical COVID-19 patients, most individuals continued to experience symptoms up to 2 months after symptom onset, with the main complaints being anosmia/ageusia, dyspnoea, or asthenia. Factors associated with persistent symptoms included age 40-60 years old, hospital admission, and abnormal auscultation at symptom onset.

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Assessment and characterisation of post-COVID-19 manifestations

Marwa Kamal et al.

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Psychiatric and neuropsychiatric sequelae of COVID-19-A systematic review

Thor Mertz Schou et al.

Summary: COVID-19 patients may exhibit psychiatric symptoms such as anxiety, depression, PTSD, cognitive deficits, fatigue, and sleep disturbances. Potential risk factors include disease severity, duration of symptoms, and female sex. Survivors of COVID-19 are at risk of psychiatric sequelae, but symptoms generally improve over time.

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ACTA ANAESTHESIOLOGICA SCANDINAVICA (2021)

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Persistent Symptoms and Disability After COVID-19 Hospitalization: Data From a Comprehensive Telerehabilitation Program

Victor Figueiredo Leite et al.

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COVID-19 sequelae in adults aged less than 50 years: A systematic review

Sandra Willi et al.

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Luc Morin et al.

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China

Xue Zhang et al.

Summary: This study found that patients with severe disease during hospitalization for COVID-19 had more post-infection symptoms and higher CAT scores at 1-year follow-up. Older age, female sex, and severe disease were identified as risk factors for fatigue, while severe disease and older age were associated with having at least 3 symptoms.

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Review Medicine, General & Internal

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BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Medicine, General & Internal

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

Francesca Salamanna et al.

Summary: A substantial proportion of COVID-19 patients experience long-term symptoms after recovery, including abnormal lung functions, neurologic complaints, olfactory dysfunctions, chronic fatigue, and pain. Despite the heterogeneity in studies, findings highlight the presence of a post-COVID syndrome in a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection.

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Summary: This meta-analysis revealed that more than 60% of patients with SARS-CoV-2 infection experienced post-COVID-19 symptoms. Fatigue and dyspnea were the most prevalent post-COVID-19 symptoms, especially at 60 and >= 90 days after onset.

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Post-COVID syndrome: A single-center questionnaire study on 1007 participants recovered from COVID-19

Bircan Kayaaslan et al.

Summary: This study investigated the prevalence and characteristics of post-COVID syndrome among COVID-19 survivors, finding that 47.5% of patients had persistent symptoms, with fatigue, myalgia, and weight loss being the most common. Factors such as severe acute COVID-19, hospitalization, and comorbidities were identified as independent factors for the development of persistent symptoms.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Olalekan Lee Aiyegbusi et al.

Summary: Patients with long COVID experience a wide range of physical and mental symptoms, with common issues including fatigue, shortness of breath, and headaches. Beyond symptoms and complications, they often report impaired quality of life, mental health issues, and employment problems.

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Xuemei He et al.

Summary: The new SARS-CoV-2 variant B.1.1.529 named Omicron, reported in South Africa, has raised global concerns after being designated as a variant of concern by the WHO. With a high number of mutations, including 15 in the spike receptor-binding domain, the Omicron variant shares similarities with previous VOCs, sparking worries about its transmissibility and immune evasion.

MEDCOMM (2021)

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Persistent Symptoms in Post-COVID-19 Patients Attending Follow-Up OPD at Sukraraj Tropical and Infectious Disease Hospital (STIDH), Kathmandu, Nepal

Anup Bastola et al.

Summary: This research aimed to study persistent symptoms in post-COVID-19 patients attending a follow-up clinic at a tertiary care hospital in Nepal. The findings show that at the time of presentation, 82.2% of patients reported having at least one persistent/new symptom, with dyspnea, fatigue, chest heaviness, and cough being the most common persistent complaints.

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