Elevated ApoB/ApoA-? ratio is associated with poor outcome in acute ischemic stroke

Background: Apolipoproteins are known atherogenic factors that play important roles in many mechanisms related to acute ischemic stroke (AIS). However, it is unclear whether the ApoB/ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I ratio is related to the prognosis of patients with AIS.Methods: We conducted a prospective cohort study in the Department of Neurology, Yangpu Hospital, School of Medicine, Tongji University and investigated the association between ApoB/ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I ratio and poor outcomes at 3 months of AIS.Results: 1,247 patients that met the eligibility criteria were enrolled in our study. We found that ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I (Adjusted odds ratios (adjOR) 0.529, 95 %CI 0.327-0.855), ApoB (adjOR 3.015, 95 %CI 1.746-5.207), and ApoB/ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I ratio (adjOR 3.986, 95 %CI 2.220-7.155) were independently associated with poor outcomes in acute ischemic stroke. During subgroup analysis, the ApoB/ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I ratio was more likely associated with poor AIS outcomes in males and patients younger than 80 with SAO(Small Artery Occlusion) and no history of diabetes or statin use. Restricted cubic spline analyses explored the correlation between poor outcomes and ApoB/ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I ratio. Conclusions: Higher ApoB, lower ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I, and higher ApoB/ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I ratios were independently associated with poor outcomes in AIS. However, ApoB and ApoA-CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I were not related to hemorrhagic transformation in AIS.

Automated summary

This study aimed to investigate the relationship between the ApoB/ApoA-I ratio and the prognosis of AIS patients. It was found that higher ApoB, lower ApoA-I, and higher ApoB/ApoA-I ratios were associated with poor outcomes in acute ischemic stroke.