期刊
JOURNAL OF CLINICAL HYPERTENSION
卷 24, 期 12, 页码 1598-1605出版社
WILEY
DOI: 10.1111/jch.14598
关键词
gut dysbiosis; hypertension; inflammation; short-chain fatty acids; sleep apnea
资金
- National Natural Science Youth Foundation of China
- Cultivating Fund for the Key Scientific Research Project of Wannan Medical College
- [81800445]
- [WK2018ZF10]
This study investigated the changes in gut microbiota in hypertensive patients with obstructive sleep apnea (OSA) and found an association between OSA, gut dysbiosis, and increased risk of metabolic diseases in hypertensive patients.
We investigated the alteration of gut microbiota and the associated metabolic risks in hypertensive patients with obstructive sleep apnea (OSA) comorbidity. Fecal and blood samples were collected from 52 hypertensive patients, who were divided into three groups: A (controls, apnea-hypopnea index[AHI] < 5, n = 15), B (mild OSA, 5 < AHI < 20, n = 17), and C (moderate-to-severe OSA, AHI > 20, n = 20). The composition of the gut microbiota was studied through 16s RNA sequencing of variable regions 3-4. Analysis of the results revealed that group C had a significant higher concentration of total cholesterol, low-density lipoprotein, and IL-1 beta compared with group A. The Shannon index showed that bacterial biodiversity was lower in OSA patients. At the phylum level, the ratio of Firmicutes to Bacteroidetes (F/B) was significantly higher in group C than in groups A and B. At the genus level, the relative abundance of short-chain fatty acids (SCFA)-producing bacteria (e.g., Bacteroides and Prevotella) was lower while the number of inflammation-related bacteria (e.g., Lactobacillus) was increased in patients with OSA. We found that the IL-1 beta level was negatively correlated with Bacteroidetes. The area under the receiver operating characteristic curve was .672 for F/B ratio in determining hypertensive patients with OSA. In patients with hypertension, OSA was associated with worse gut dysbiosis, as evidenced by decreased levels of short-chain fatty acids-producing bacteria and increased number of inflammation-related bacteria. The differences in gut microbiota discriminate hypertensive patients with OSA from those without and may result in an enhanced inflammatory response and increase the risk of metabolic diseases.
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