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Article
Medicine, General & Internal
Mohammad Talaei et al.
Summary: This prospective population-based study investigates the determinants of pre-vaccination antibody responses to SARS-CoV-2. The study finds that occupation, international travel, frequency of visits to shops and other indoor public places, BMI, ethnicity, and alcohol consumption are associated with the risk of SARS-CoV-2 seropositivity. Light physical exercise is associated with lower risk. Among seropositive participants, factors such as BMI, ethnicity, occupation, travel, and frequency of visits to public places are associated with higher antibody titres.
Review
Endocrinology & Metabolism
Sarra Smati et al.
Summary: The CORONADO study in France aimed to describe the phenotype of hospitalized diabetes patients with COVID-19 and identify prognostic factors. The study found that diabetes was a major risk factor for severe forms of COVID-19. The results showed that older age, microvascular complications, use of insulin or statins prior to admission, dyspnea on admission, and biomarkers indicating infection severity were associated with an increased risk of death.
CURRENT DIABETES REPORTS
(2022)
Article
Health Care Sciences & Services
Jodi K. McCloskey et al.
Summary: Communities of color have higher rates of SARS-COV-2 infection compared to non-Latino White communities, even after controlling for medical and social factors.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Cell Biology
Manu Sudhakar et al.
Summary: Epidemiological data from multiple countries indicate an increased prevalence of obesity, especially central obesity, among hospitalized subjects with COVID-19. Obesity is a metabolic disorder that affects immune and endocrine function, and it is a major contributing factor to adverse outcomes in COVID-19.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Sian A. Bradley et al.
Summary: This study found that diabetes significantly increases the risk of severe COVID-19, ARDS, mortality, and the need for mechanical ventilation in hospitalized COVID-19 patients, with a prevalence of 31% in the studied cohort.
JOURNAL OF DIABETES
(2022)
Review
Endocrinology & Metabolism
Francesco Prattichizzo et al.
Summary: This meta-analysis aimed to explore the impact of HbA1c values at hospital pre-admission or at-admission on COVID-19 mortality or worsening in patients with diabetes. The results from seven observational studies showed that HbA1c was linearly associated with increased risk of COVID-19 mortality or worsening, especially in patients with poor glycaemic control.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Endocrinology & Metabolism
Wanteng Wang et al.
Summary: The meta-analysis indicated a correlation between insulin usage and increased mortality in diabetic patients with COVID-19, suggesting that insulin requirement might indicate a poor prognosis.
ENDOCRINE RESEARCH
(2022)
Review
Medical Laboratory Technology
Sumith Roy et al.
Summary: This systematic review analyzes the association between impaired glucose regulation and COVID-19, finding consistent and reproducible associations. However, there are limitations in the evidence, including inadequate adjustment for risk factors and lack of data on insulin resistance or glycemia measures. Future research with robust risk factor data collection is needed to further understand these issues.
TRANSLATIONAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Thomas Yates et al.
Summary: Obesity and ethnicity have been found to be risk factors for COVID-19 outcomes. This study reveals that the association between body mass index (BMI) and COVID-19 mortality is stronger in ethnic minority groups, suggesting that the ethnic risk of COVID-19 mortality depends on BMI.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
R. Pranata et al.
Summary: This meta-analysis revealed a dose-response relationship between body mass index (BMI) and poor outcome in patients with COVID-19, indicating that an increase in BMI is associated with an increased risk of poor outcomes.
DIABETES & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yanbin Du et al.
Summary: This study examined the association between BMI and COVID-19 severity and mortality through a meta-analysis of 16 observational studies involving 109,881 patients. The findings showed a linear dose-response relationship between BMI and critical COVID-19 and mortality, with patients with BMI > 30 kg/m(2) at higher risk. Age and obesity were also found to impact this association.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Cardiac & Cardiovascular Systems
Nicholas S. Hendren et al.
Summary: This study found that obese patients are more likely to be hospitalized with COVID-19, and are at higher risk of in-hospital death or mechanical ventilation, particularly if young (age <= 50 years). Additionally, obese patients are also at higher risk for venous thromboembolism and dialysis. These observations support clear public health messaging and rigorous adherence to COVID-19 prevention strategies in all obese individuals regardless of age.
Review
Endocrinology & Metabolism
Jamie Hartmann-Boyce et al.
Summary: The review found that diabetes is a risk factor for severe COVID-19 outcomes, especially for individuals with higher blood glucose levels and type 1 diabetes. However, there is a lack of data on whether diabetes predisposes individuals to SARS-CoV-2 infection.
Review
Medicine, General & Internal
Yahya Mahamat-Saleh et al.
Summary: This study found that diabetes, hypertension, obesity, and smoking were associated with higher COVID-19 mortality, contributing to nearly 30% of COVID-19 deaths.
Article
Medicine, General & Internal
George N. Ioannou et al.
Summary: This study found that the risk factors for SARS-CoV-2 infection and mortality changed over time before March 2021, with significant variations in risk associations for Black, American Indian/Alaska Native, and urban residents at different stages of the pandemic.
Letter
Endocrinology & Metabolism
Huei-Kai Huang et al.
DIABETES OBESITY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Sabrina Schlesinger et al.
Summary: This study aimed to identify high-risk phenotypes of diabetes associated with COVID-19 severity and death, showing that individuals with a more severe course of diabetes have a poorer prognosis of COVID-19 compared with individuals with a milder course of disease.
Review
Endocrinology & Metabolism
Maryam Heidarpour et al.
Summary: This study systematically reviewed the association between prediabetes and severe outcomes of COVID-19, finding a significant link and suggesting early detection of prediabetes could help improve prognosis in infected individuals.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Review
Endocrinology & Metabolism
Gerui Li et al.
Summary: COVID-19 and diabetes may have a synergistic effect, with diabetes increasing susceptibility to the virus while worsened prognosis may further impair glucose regulation in those with the disease. Proper glycemic management in COVID-19 patients, particularly those with severe illness, is crucial in reducing fatality rates.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Maria Dalamaga et al.
Summary: A growing body of evidence suggests that obesity and increased visceral adiposity are strongly linked to adverse outcomes and death due to COVID-19. Recent meta-analyses based on observational studies have shown that obesity increases the risks of infection, severe infection, hospitalization, ICU admission, IMV, and mortality in COVID-19 patients, particularly in severe obesity, with accentuated risks in younger individuals (age <= 50 years old). Mechanistic and large epidemiologic studies using big data sources are necessary to establish preventive and therapeutic approaches for patients with obesity.
CURRENT OBESITY REPORTS
(2021)
Article
Medicine, General & Internal
Sidney Aung et al.
Summary: The study analyzed data from the Covid-19 Citizen Science (CCS) Study, finding various characteristics and behaviors associated with prevalent SARS-CoV-2 infection in a large, geographically diverse cohort of approximately 36,041 participants. The identified risk factors included being a healthcare worker, living with at least one school-aged child, having pets at home, and having immunodeficiency, among others.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Angelo Avogaro et al.
Summary: The study found that metformin may reduce the risk of COVID-19-related mortality, while insulin may increase the risk. Other classes of antidiabetic drugs were neutral. The results of the study are influenced by channeling bias.
ACTA DIABETOLOGICA
(2021)
Review
Medicine, General & Internal
Marina Treskova-Schwarzbach et al.
Summary: This study used an umbrella review approach to summarize global evidence on the risk of severe COVID-19 outcomes in patients with pre-existing health conditions. The risk of adverse COVID-19 health outcomes is consistently increased in certain patient subgroups across geographical regions, showing high variability in others. The results can help inform COVID-19 vaccine prioritization or other intervention strategies.
Article
Public, Environmental & Occupational Health
Zixin Cai et al.
Summary: This meta-analysis found a significant association between obesity and increased risk of infection, hospitalization, clinically severe disease, mechanical ventilation, intensive care unit admission, and mortality in patients with COVID-19. It is important to raise awareness of these associations in individuals with obesity during the COVID-19 pandemic.
Article
Endocrinology & Metabolism
Guoying Wang et al.
Summary: This study revealed the intersectionality of obesity and social factors in modulating incident risk of COVID-19 in a sample of US Black and Hispanic middle-aged mothers. Methodologically, the findings underscore the importance of accounting for potential selection bias in COVID-19 testing in order to obtain unbiased estimates of COVID-19 infection.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Immunology
Daniel B. Horton et al.
Summary: This study found that healthcare workers were more likely to be infected with SARS-CoV-2 and symptoms such as dyspnea and neurologic changes could persist for months. The intensity and trajectory of IgG production differed among individuals with different severity of symptoms.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Min Gao et al.
Summary: The study found that above a BMI of 23 kg/m(2), there is a linear increase in the risk of severe consequences of COVID-19 leading to hospital admission and death, and a linear increase in ICU admission risk across the entire BMI range. The impact of increasing BMI is particularly notable in individuals younger than 40 years and of Black ethnicity.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Chengxia Kan et al.
Summary: The systematic review and meta-analysis found that metformin and sulfonylurea use were associated with lower mortality risk in patients with type 2 diabetes who have COVID-19, while insulin use was linked to higher mortality. There was no significant difference in mortality between DPP-4 inhibitor users and non-users, indicating a need for further exploration of the effects of antidiabetic agents in this population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Health Care Sciences & Services
Maria Figueroa-Pizano et al.
Summary: Patients with diabetes mellitus have a higher risk of developing severe complications in COVID-19 due to factors such as hyperglycemia, weakened immunity, chronic inflammation, and other comorbidities commonly seen in diabetes. The role of SARS-CoV-2 receptor and its variations in individuals with diabetes may contribute to the higher susceptibility to severe outcomes in COVID-19.
AIMS PUBLIC HEALTH
(2021)
Review
Endocrinology & Metabolism
Suheda Erener
MOLECULAR METABOLISM
(2020)
Article
Multidisciplinary Sciences
Gareth J. Griffith et al.
NATURE COMMUNICATIONS
(2020)
Article
Medicine, General & Internal
Frederick K. Ho et al.
Review
Respiratory System
Anne E. Dixon et al.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2018)
Review
Immunology
D. Frasca et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2017)
News Item
Medicine, General & Internal
Bridget M. Kuehn
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2017)
Review
Nutrition & Dietetics
Catherine J. Andersen et al.
ADVANCES IN NUTRITION
(2016)
Article
Endocrinology & Metabolism
J. M. Fernandez-Real et al.
Article
Nutrition & Dietetics
Fatima Perez de Heredia et al.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2012)
