GLP-1 Receptor Agonists and SGLT-2 Inhibitors as Adjuncts to Insulin in Type 1 Diabetes: Benefits and Concerns

Review Endocrinology & Metabolism

Glucagon-like peptide-1 receptor agonists as adjunctive treatment for type 1 diabetes: Renewed opportunities through tailored approaches?

Alessandra Kobayati et al.

Summary: Exogenous insulin remains the main treatment for type 1 diabetes (T1D), but adjunctive pharmacotherapies, such as GLP-1RAs, show potential in improving glycemic control and offering additional benefits for T1D patients. However, conflicting trial findings and underestimation of GLP-1 agonism's potential in T1D treatment have been observed. This narrative review aims to summarize the current evidence-based literature and explore uncharted opportunities with GLP-1 agonism in T1D populations.

DIABETES OBESITY & METABOLISM (2022)

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Article Chemistry, Medicinal

The Reporting Frequency of Ketoacidosis Events with Dapagliflozin from the European Spontaneous Reporting System: The DAPA-KETO Study

Gabriella di Mauro et al.

Summary: Evaluating the occurrence of dapagliflozin-induced ketoacidosis events using the European spontaneous reporting system, it was found that dapagliflozin is associated with a higher reporting frequency of ketoacidosis compared to DPP-4 inhibitors or insulins and a lower reporting frequency compared to other SGLT2 inhibitors.

PHARMACEUTICALS (2022)

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Article Endocrinology & Metabolism

Clinical and Safety Outcomes With GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 1 Diabetes: A Real-World Study

Khary Edwards et al.

Summary: The use of GLP-1RAs and SGLT2is in the management of T1DM in real-world practice has shown clinically relevant benefits, with a reduction in weight and HbA(1c). However, the use of SGLT2is is associated with an increased risk of diabetic ketoacidosis, requiring careful patient selection and monitoring.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Review Nutrition & Dietetics

Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin-Dependent and Insulin-Independent Mechanisms: An Integrative Approach

George D. Dimitriadis et al.

Summary: Glucose homeostasis is regulated by insulin, with key roles played by the liver, kidneys, skeletal muscle, and adipose tissue. Insulin resistance during sleep helps maintain normal blood glucose levels by switching to fatty acid oxidation in muscles and modulating glucose production from the liver and kidneys. Postprandial glucose fluctuations are optimally regulated by a combination of various mechanisms, including the liver's critical role in disposing ingested glucose and preventing acute increases in blood glucose levels after meals.

NUTRIENTS (2021)

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Review Endocrinology & Metabolism

Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms

Karen D. Corbin et al.

ENDOCRINE REVIEWS (2018)

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Review Endocrinology & Metabolism

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

Jordan Rowlands et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Article Medicine, Research & Experimental

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients

Ele Ferrannini et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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GLP-1 Receptor Agonists and SGLT-2 Inhibitors as Adjuncts to Insulin in Type 1 Diabetes: Benefits and Concerns

相关参考文献

Glucagon-like peptide-1 receptor agonists as adjunctive treatment for type 1 diabetes: Renewed opportunities through tailored approaches?

The Reporting Frequency of Ketoacidosis Events with Dapagliflozin from the European Spontaneous Reporting System: The DAPA-KETO Study

Clinical and Safety Outcomes With GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 1 Diabetes: A Real-World Study

Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin-Dependent and Insulin-Independent Mechanisms: An Integrative Approach

Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients

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