4.7 Article

A unique piezolyte mechanism of TMAO: Hydrophobic interactions under extreme pressure conditions

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Physical

Small-to-large length scale transition of TMAO interaction with hydrophobic solutes

Angelina Folberth et al.

Summary: Our study investigates the impact of TMAO on the solvation of nonpolar solutes in water through MD simulations and free-energy calculations. We find that TMAO can exhibit a surfactant-like behavior, preferring to bind to large solutes and reducing the free-energy cost of solute-cavity formation. This behavior reinforces the solvent-mediated attraction between large solutes by means of an entropic force related to the accumulation of TMAO at interfaces.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2022)

Article Chemistry, Physical

Cosolvent Exclusion Drives Protein Stability in Trimethylamine N-Oxide and Betaine Solutions

Pritam Ganguly et al.

Summary: This study investigated the solvation thermodynamics of proteins in two osmolyte solutions using various experimental and simulation techniques. It was found that existing force fields were unable to accurately capture the solvation properties of proteins and led to unphysical denaturation. By developing a new force field and introducing appropriate scaling, the experimental solution properties were successfully reproduced and the unphysical denaturation was prevented.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2022)

Article Chemistry, Physical

Length-Scale Effects in Hydrophobic Polymer Collapse Transitions

Nico F. A. van der Vegt

Summary: The study of molecular mechanisms for cosolvent-driven hydrophobic polymer collapse transitions in water is crucial for the field of smart responsive materials. While new phenomena have been discovered and understood, the elementary mechanisms contributing to polymer coil-globule transitions in different cosolvent-water systems remain unclear.

JOURNAL OF PHYSICAL CHEMISTRY B (2021)

Article Chemistry, Physical

Pressure Unfolding of Proteins: New Insights into the Role of Bound Water

Andrea Arsiccio et al.

Summary: High pressure can lead to protein denaturation and loss of function by affecting volume and eliminating cavities in the native state. A novel computational approach shows that the reduction in volume of bound water is the key driver of protein denaturation under high pressure, with different unfolding mechanisms observed for proteins of different sizes. These findings provide insight into pressure-induced denaturation of proteins and offer a promising computational method for studying this phenomenon.

JOURNAL OF PHYSICAL CHEMISTRY B (2021)

Article Biochemistry & Molecular Biology

Protein adaptation to high hydrostatic pressure: Computational analysis of the structural proteome

Samvel Avagyan et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2020)

Article Chemistry, Physical

Hydration properties of a protein at low and high pressures: Physics of pressure denaturation

Masao Inoue et al.

JOURNAL OF CHEMICAL PHYSICS (2020)

Article Chemistry, Multidisciplinary

Pressure-Sensitive and Osmolyte-Modulated Liquid-Liquid Phase Separation of Eye-Lens γ-Crystallins

Sueleyman Cinar et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Polymer Science

Does Preferential Adsorption Drive Cononsolvency?

Swaminath Bharadwaj et al.

MACROMOLECULES (2019)

Article Chemistry, Multidisciplinary

Pressure-Induced Dissolution and Reentrant Formation of Condensed, Liquid-Liquid Phase-Separated Elastomeric α-Elastin

Hasan Cinar et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Article Biophysics

Putting the Piezolyte Hypothesis under Pressure

Christina M. Papini et al.

BIOPHYSICAL JOURNAL (2017)

Review Biochemistry & Molecular Biology

Marine Biodiversity, Biogeography, Deep-Sea Gradients, and Conservation

Mark J. Costello et al.

CURRENT BIOLOGY (2017)

Article Chemistry, Multidisciplinary

Toward Extreme Biophysics: Deciphering the Infrared Response of Biomolecular Solutions at High Pressures

Sho Imoto et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Physical

Design principles for high-pressure force fields: Aqueous TMAO solutions from ambient to kilobar pressures

Christoph Hoelzl et al.

JOURNAL OF CHEMICAL PHYSICS (2016)

Article Multidisciplinary Sciences

How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory

Jagannath Mondal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Physics, Multidisciplinary

Reentrant Liquid-Liquid Phase Separation in Protein Solutions at Elevated Hydrostatic Pressures

Johannes Moeller et al.

PHYSICAL REVIEW LETTERS (2014)

Article Multidisciplinary Sciences

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

Jianqiang Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Marine fish may be biochemically constrained from inhabiting the deepest ocean depths

Paul H. Yancey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Chemistry, Physical

Complex Formation in Aqueous Trimethylamine-N-oxide (TMAO) Solutions

Johannes Hunger et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2012)

Article Biophysics

The Behavior of the Hydrophobic Effect under Pressure and Protein Denaturation

J. Raul Grigera et al.

BIOPHYSICAL JOURNAL (2010)

Article Chemistry, Multidisciplinary

Simulation of the pressure and temperature folding/unfolding equilibrium of a small RNA hairpin

Angel E. Garcia et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Review Biochemistry & Molecular Biology

Recent applications of Kirkwood-Buff theory to biological systems

Veronica Pierce et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2008)

Article Biochemistry & Molecular Biology

Solute accumulation in the deep-sea bacterium Photobacterium profundum

DD Martin et al.

EXTREMOPHILES (2002)