☆ 4.6 Review

How statin drugs affect exosomes?

JOURNAL OF CELLULAR BIOCHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cell Biology

The role of exosomal miRNA in nonalcoholic fatty liver disease

Ali Mahmoudi et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) affects a significant portion of the population and is associated with other metabolic diseases. Current diagnostic methods for NAFLD are invasive or lack accuracy, and monitoring the response to treatment is challenging. Exosomes, nano-scaled extracellular vesicles, have the potential to be used for diagnosis and therapeutics in liver diseases, including NAFLD. They play a vital role in cell-cell communication and mediate miRNAs, which can be used as biomarkers for NAFLD.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effects of statins on the biological features of mesenchymal stem cells and therapeutic implications

Armita Mahdavi Gorabi et al.

Summary: In this review, the impact of statins on mesenchymal stem cell behaviors and the molecular pathways responsible for such effects are discussed, emphasizing the potential benefits of the pleiotropic effects of statins on cell therapy and tissue engineering approaches. Furthermore, different systems for local delivery of statins are also reviewed in order to maintain a sufficient dose of active statins at the desired site of the body.

HEART FAILURE REVIEWS (2021)

添加到收藏夹

Article Allergy

Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways

Khadijeh Koushki et al.

Summary: Atherosclerosis is a cardiovascular disease where statin medications are one of the most effective treatments. Recent studies show that statins not only lower lipid levels, but also have inhibitory and stimulatory effects on inflammasomes and toll-like receptors. The contradictory effects of different statins are related to factors such as dosage, chemistry, pharmacokinetics, and danger signals.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

添加到收藏夹

Article Biology

Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup

Francesc X. Guix et al.

Summary: As neurons age, their ability to degrade proteins and membranes decreases, leading to reduced cell function and survival. Aging neurons in culture secrete more small extracellular vesicles filled with cholesterol, which may negatively impact neighboring and distant cells.

LIFE SCIENCE ALLIANCE (2021)

添加到收藏夹

Article Medicine, General & Internal

Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis

Amir Vahedian-Azimi et al.

Archives of Medical Science (2021)

添加到收藏夹

Review Cell Biology

The exosome journey: from biogenesis to uptake and intracellular signalling

Sonam Gurung et al.

Summary: Exosomes have vast potential in clinical applications, and understanding their biology is crucial. The processes of exosome biogenesis, transport, and uptake involve numerous influencing factors.

CELL COMMUNICATION AND SIGNALING (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting AMPK by Statins: A Potential Therapeutic Approach

Sajad Dehnavi et al.

Summary: Statins, a group of lipid-lowering drugs, have been shown to regulate multiple proteins associated with different cellular pathways, including the 5'-adenosine monophosphate-activated protein kinase (AMPK) pathway, which plays a significant role in maintaining metabolic homeostasis. Statins can affect the AMPK pathway in various physiological and pathological ways, resulting in therapeutic effects on cancer, cardiovascular diseases, neurodegenerative disorders, and other conditions.

DRUGS (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Emerging Non-statin Treatment Options for Lowering Low-Density Lipoprotein Cholesterol

Chandni Bardolia et al.

Summary: This narrative review discusses the role of ezetimibe, PCSK9 inhibitors, BDA, and inclisiran in therapy, and describes their relative pharmacokinetic (PK) profiles, efficacy and safety as monotherapy and combination therapy, as well as the cardiovascular benefits when used for hypercholesterolemia.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Letter Medicine, General & Internal

Statins as anti-pyroptotic agents

Masoomeh Khalifeh et al.

Summary: Pyroptosis is a regulated form of cell death that enhances innate immunity, but excessive pyroptosis can lead to inflammation and tissue damage. Recent reports suggest that statins may modulate pyroptosis and potentially target it in different diseases.

ARCHIVES OF MEDICAL SCIENCE (2021)

添加到收藏夹

Review Cell Biology

The role of lipids in exosome biology and intercellular communication: Function, analytics and applications

Javier Donoso-Quezada et al.

Summary: Exosomes are important extracellular vesicles with compositions related to the progression of various diseases. Lipids, as crucial components of exosomes, play significant roles in exosome biology and intercellular communication. Exosome lipidomics is an emerging discipline that offers insights into the discovery of new lipid species for biomedical applications.

TRAFFIC (2021)

添加到收藏夹

Letter Medicine, General & Internal

Effect of atorvastatin on delirium status of patients in the intensive care unit: a randomized controlled trial

Seyed Mojtaba Sohrevardi et al.

Summary: The study showed that the use of atorvastatin significantly reduced delirium status and increased delirium-free days in ICU patients.

ARCHIVES OF MEDICAL SCIENCE (2021)

添加到收藏夹

Article Oncology

Cholesterol impairs hepatocyte lysosomal function causing M1 polarization of macrophages via exosomal miR-122-5p

Zhibo Zhao et al.

EXPERIMENTAL CELL RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ageing: Molecular mechanisms

Afsane Bahrami et al.

AGEING RESEARCH REVIEWS (2020)

添加到收藏夹

Review Peripheral Vascular Disease

The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review

Hamideh Kouhpeikar et al.

CURRENT ATHEROSCLEROSIS REPORTS (2020)

添加到收藏夹

Review Immunology

Exosomes: Effectual players in rheumatoid arthritis

Fataneh Tavasolian et al.

AUTOIMMUNITY REVIEWS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis

Maryam Mahjoubin-Tehran et al.

MOLECULAR METABOLISM (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

Muyu Yu et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Letter Medicine, General & Internal

Statins and C-reactive protein: in silico evidence on direct interaction

Neda Shakour et al.

ARCHIVES OF MEDICAL SCIENCE (2020)

添加到收藏夹

Article Medicine, General & Internal

Statins and the COVID-19 main protease: in silico evidence on direct interaction

Zeljko Reiner et al.

ARCHIVES OF MEDICAL SCIENCE (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia

Adam Oesterle et al.

CURRENT VASCULAR PHARMACOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Simvastatin Attenuates Cardiac Fibrosis via Regulation of Cardiomyocyte-Derived Exosome Secretion

Hsuan-Fu Kuo et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Article Immunology

Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis

Peng Zhang et al.

JOURNAL OF NEUROINFLAMMATION (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Simvastatin mediates inhibition of exosome synthesis, localization and secretion via multicomponent interventions

Ankur Kulshreshtha et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Neurosciences

Statins and the Brain: More than Lipid Lowering Agents?

Anna Fracassi et al.

CURRENT NEUROPHARMACOLOGY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The therapeutic and diagnostic role of exosomes in cardiovascular diseases

Parvin Zamani et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Effect of statins on atherosclerotic plaque

Shone O. Almeida et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cholesterol and the journey of extracellular vesicles

Frank W. Pfrieger et al.

JOURNAL OF LIPID RESEARCH (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Effect of statins on toll-like receptors: a new insight to pleiotropic effects

Afsane Bahrami et al.

PHARMACOLOGICAL RESEARCH (2018)

添加到收藏夹

Article

Exosomes impact survival to radiation exposure in cell line models of nervous system cancer

Oliver D. Mrowczynski et al.

Oncotarget (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes

Peter Willeit et al.

DIABETES (2017)

添加到收藏夹

Review Cell Biology

Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?

Hamed Mirzaei et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

添加到收藏夹

Article Immunology

Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway

Xiao-Li Li et al.

JOURNAL OF NEUROINFLAMMATION (2016)

添加到收藏夹

Review Hematology

The impact of statin therapy on plasma levels of von Willebrand factor antigen Systematic review and meta-analysis of randomised placebo-controlled trials

Amirhossein Sahebkar et al.

THROMBOSIS AND HAEMOSTASIS (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Statin therapy reduces plasma endothelin-1 concentrations: A meta-analysis of 15 randomized controlled trials

Amirhossein Sahebkar et al.

ATHEROSCLEROSIS (2015)

添加到收藏夹

Review Hematology

Association between statin use and plasma D-dimer levels

Amirhossein Sahebkar et al.

THROMBOSIS AND HAEMOSTASIS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

Corina Serban et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Recent advances in pharmacotherapy for hypertriglyceridemia

Amirhossein Sahebkar et al.

PROGRESS IN LIPID RESEARCH (2014)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

New Therapies Targeting apoB Metabolism for High-Risk Patients with Inherited Dyslipidaemias: What Can the Clinician Expect?

Amirhossein Sahebkar et al.

CARDIOVASCULAR DRUGS AND THERAPY (2013)

添加到收藏夹

Review Pharmacology & Pharmacy

New LDL-Cholesterol Lowering Therapies: Pharmacology, Clinical Trials, and Relevance to Acute Coronary Syndromes

Amirhossein Sahebkar et al.

CLINICAL THERAPEUTICS (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

Katrin J. Svensson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Clinical Neurology

Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-β Peptide

Konstantin Glebov et al.

NEURODEGENERATIVE DISEASES (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Simvastatin Therapy Reduces Prooxidant-Antioxidant Balance: Results of a Placebo-Controlled Cross-Over Trial

Seyyed M. R. Parizadeh et al.

LIPIDS (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

Irfan Y. Tamboli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease

JB Pereira-Leal et al.

FEBS LETTERS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.