How statin drugs affect exosomes?

Statins reduce serum cholesterol and isoprenoids by the inhibition of cholesterol synthesis in the mevalonate pathway. Exosomes are extracellular vesicles (30-200 nm) released by all cells that regulate cell-to-cell communication in health and disease by transferring functional proteins, metabolites and nucleic acids to recipient cells. There are many reports that show an effect of statins on exosomes, from their production and release to their content and performance. In this review, we have summarized existing data on the impact of statins on the biosynthesis, secretion, content, uptake and function of exosomes.

Automated summary

Statins reduce serum cholesterol and isoprenoids by inhibiting cholesterol synthesis. Exosomes, extracellular vesicles released by all cells, play a role in cell-to-cell communication by transferring proteins, metabolites, and nucleic acids. Many studies have shown the effects of statins on exosomes, including their production, release, content, uptake, and function.