SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression

Metabolism reprogramming plays an important role in tumorigenesis and osteosarcoma metastasis. Sine oculis homeobox 4 (SIX4) is reported to be a key transcription factor that is involved in glycolysis reprogramming of cancer cells. However, the role of SIX4 in osteosarcoma progression remains unknown. The expression profile of SIX4 in OS was evaluated in surgery samples of osteosarcoma patients. Functional studies were performed in vitro and in vivo. We found that SIX4 is significantly overexpressed in osteosarcoma and related to the undesirable prognosis of osteosarcoma patients. SIX4 promotes progression of osteosarcoma via upregulating isocitrate dehydrogenase 1 (IDH1), which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.

Automated summary

This study found that SIX4 is overexpressed in osteosarcoma and is associated with poor prognosis. SIX4 promotes osteosarcoma progression by upregulating isocitrate dehydrogenase 1 (IDH1), providing novel prognostic biomarkers and potential therapeutic targets for osteosarcoma patients.