Up-Titration of Sacubitril/Valsartan Among Patients With Heart Failure and Preserved Ejection Fraction

Article Cardiac & Cardiovascular Systems

A dose-response relationship of renin-angiotensin system blockers and beta-blockers in patients with acute heart failure syndrome: a nationwide prospective cohort study

Kyung An Kim et al.

Summary: This study evaluated the dose-response relationship between renin-angiotensin system blockers (RASBs) or beta-blockers (BBs) and survival in patients with acute heart failure syndrome (AHFS). The results showed that the use of RASBs at discharge was associated with a significant reduction in all-cause mortality risk in AHFS patients with reduced ejection fraction, while BBs did not have a significant impact. This highlights the importance of initiating and increasing the dose of RASBs to the maximally tolerated dose in AHFS patients during the transition period.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2022)

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Article Cardiac & Cardiovascular Systems

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary

Paul A. Heidenreich et al.

Summary: The 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure replaces previous guidelines and aims to provide patient-centric recommendations for clinicians based on contemporary evidence, with the goal of improving quality of care and aligning with patients' interests.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

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Article Medicine, General & Internal

Optimal Pharmacologic Treatment of Heart Failure With Preserved and Mildly Reduced Ejection Fraction A Meta-analysis

Boyang Xiang et al.

Summary: The study aimed to compare the outcomes associated with different drug combinations for the treatment of HFpEF and HFmrEF. The results showed that SGLT2 inhibitors, ARNIs, and MRAs were associated with a decrease in the risk of HF hospitalization, with SGLT2 inhibitors being the optimal drug class in reducing the risk for HF admission.

JAMA NETWORK OPEN (2022)

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Article Cardiac & Cardiovascular Systems

Epidemiology of Heart Failure A Contemporary Perspective

Veronique L. Roger

Summary: This review summarizes recent studies on the epidemiology of heart failure (HF) over the past decade, indicating that while the incidence of HF is mostly flat or declining, the burden of mortality and hospitalization remains significant, especially with major disparities among younger Black men and women. Emerging risk factors and holistic management approaches may help improve the treatment and management of HF.

CIRCULATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Influence of study discontinuation during the run-in period on the estimated efficacy of sacubitril/valsartan in the PARAGON-HF trial

Kota Suzuki et al.

Summary: In the PARAGON-HF trial, 16.1% of patients failed to complete the run-in period, with those with more advanced heart failure at higher risk. Re-analyzing the study outcomes showed that sacubitril/valsartan treatment reduced the overall incidence of heart failure hospitalizations and cardiovascular death compared to valsartan.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

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Article Cardiac & Cardiovascular Systems