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Review
Cardiac & Cardiovascular Systems
Imran Sulemankhil et al.
Summary: With the widespread administration of Pfizer-BioNTech, Moderna, and Janssen vaccines, the incidence of severe COVID-19 infection has significantly decreased. However, there have been reports of serious side effects associated with these vaccines. This article describes a case of myocarditis following the administration of the Janssen vaccine in a healthy, young male and reviews the available literature on COVID-19 vaccine-related myocarditis and its possible pathogenesis. Despite the potential risk of myocarditis, the benefits of the vaccines outweigh the risks.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Martina Patone et al.
Summary: The study found that there is an increased risk of myocarditis associated with the first dose of ChAdOx1 and BNT162b2 vaccines, as well as the first and second doses of the mRNA-1273 vaccine in the 1-28 days post-vaccination period. Additionally, individuals with SARS-CoV-2 infection also face a greater risk of myocarditis, pericarditis, and cardiac arrhythmia.
Article
Multidisciplinary Sciences
Lee S. Nguyen et al.
Summary: This study analyzed 5108 reports of drug-induced myocarditis and reported the temporal trends and overall mortality, identifying emerging drug classes associated with myocarditis.
NATURE COMMUNICATIONS
(2022)
Letter
Cardiac & Cardiovascular Systems
Carolyn M. Rosner et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Letter
Medicine, General & Internal
Maurizio Pieroni et al.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
Samantha Lane et al.
Summary: The incidence of myocarditis and pericarditis following COVID-19 vaccination is very low, and the benefits of vaccination outweigh the risks. The reporting rates of myocarditis and pericarditis in immunocompromised individuals are similar to the overall population, but with some distinct characteristics.
Review
Endocrinology & Metabolism
Mahmoud Nassar et al.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Letter
Cardiac & Cardiovascular Systems
Husam M. Salah et al.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Mansour et al.
Summary: We report two cases of myocarditis, occurring in two young and previously healthy individuals, temporally associated with the second dose of the mRNA-COVID-19 vaccine. Both patients presented with acute chest pain, changes on electrocardiogram (ECG), and elevated serum troponin levels within two days of receiving their second dose. Cardiac magnetic resonance (CMR) findings were consistent with acute myocarditis.
Article
Medicine, General & Internal
Guy Witberg et al.
Summary: Among 2.5 million patients who received the BNT162b2 mRNA vaccine in a large Israeli health care system, the incidence of myocarditis at 42 days was 2.13 cases per 100,000 persons, with the highest incidence (10.69 per 100,000 persons) among male patients between the ages of 16 and 29 years. Most cases of myocarditis were mild or moderate.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt et al.
Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.
Letter
Cardiac & Cardiovascular Systems
Kathryn F. Larson et al.
Article
Medicine, General & Internal
Noam Barda et al.
Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Saif Abu Mouch et al.
Summary: This study reported six cases of myocarditis occurring shortly after BNT162b2 vaccination, all in young males with mild clinical course. All patients responded to the vaccine, and myocarditis post-BNT162b2 vaccination may be considered an adverse reaction.
Article
Public, Environmental & Occupational Health
Julia W. Gargano et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Article
Cardiac & Cardiovascular Systems
Audrey Dionne et al.
Summary: This study reviewed comprehensive cardiac imaging results in children with myocarditis after receiving the BNT162b2 COVID-19 vaccine. Most cases of myocarditis occurred in boys after the second dose, and patients showed mild symptoms in short-term follow-up. Long-term risks of post-vaccination myocarditis remain unknown, necessitating larger studies for vaccination recommendations in this population.
