4.2 Letter

Cable-based ICD lead study

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Article Cardiac & Cardiovascular Systems

Rationale and design of the Lead Evaluation for Defibrillation and Reliability study: Safety and efficacy of a novel ICD lead design

George H. Crossley et al.

Summary: The LEADR Clinical Study aims to assess the long-term reliability of a novel defibrillator lead design using Bayesian methods and virtual patient data. The study will enroll 500 to 900 patients for 18 months to 3 years of follow-up, with multiple clinical assessments at different time points.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2023)

Article Cardiac & Cardiovascular Systems

In vitro modeling accurately predicts cardiac lead fracture at 10 years

Bruce L. Wilkoff et al.

Summary: This study demonstrated a predictive model for cardiac lead fracture-free survival, which was validated by comparing the results with observed clinical performance data. The model showed good agreement with field survival data, indicating its potential to predict lead performance effectively. The average model error was low, suggesting the reliability of the model in predicting lead fracture-free survival.

HEART RHYTHM (2021)

Article Cardiac & Cardiovascular Systems

Extraction of a very old His bundle pacing lead: A safe and effective procedure?

Federico Migliore et al.

Summary: Permanent His bundle pacing (HBP) has become increasingly popular in clinical practice in recent years, but there are limited reports on the extraction of the commonly used lumenless pacing lead. Concerns remain about possible injury to the conduction system during extraction and the lack of a lumen for placing a locking stylet during transvenous lead extraction (TLE).

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2021)