Biphasic transcriptional and posttranscriptional regulation of MYB by androgen signaling mediates its growth control in prostate cancer

Article Oncology

MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer

Sanjeev Kumar Srivastava et al.

Summary: The study revealed that MYB and AR interact in prostate cancer cells, and overexpression of MYB can lead to resistance to castration and rapid growth post-castration, resulting in shorter survival of mice.

BRITISH JOURNAL OF CANCER (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Cell Biology

Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications

Sirin Saranyutanon et al.

Summary: Nicotine induces M2 polarization of macrophages, enhancing their growth, motility, and invasion, potentially through the Src-STAT3 signaling axis. This novel role of nicotine in immunosuppression could be implicated in the pathogenesis of various diseases.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Review Oncology

Intricate crosstalk between MYB and noncoding RNAs in cancer

Dingyu Hu et al.

Summary: MYB is often overexpressed in malignant tumors and may play a carcinogenic role in cancer initiation and development. Studies have shown that MYB not only regulates protein-coding genes, but also affects noncoding RNAs, influencing the complexity of cancer progression. ncRNAs regulate the expression of downstream genes at transcription, RNA processing, and translation levels, and also play important roles in regulating MYB expression.

CANCER CELL INTERNATIONAL (2021)

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Article Cell Biology

Suppressing BCL-XL increased the high dose androgens therapeutic effect to better induce the Enzalutamide-resistant prostate cancer autophagic cell death

Zhendong Xiang et al.

Summary: The study found that Enzalutamide-resistant prostate cancer cells can be suppressed by high doses of the androgen DHT. Targeting the BCL-XL protein can enhance the inhibitory effect of high-dose DHT on cell growth, promoting cell death.

CELL DEATH & DISEASE (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

MYB oncoproteins: emerging players and potential therapeutic targets in human cancer

Ylenia Ciciro et al.

Summary: MYB transcription factors are highly conserved from plants to vertebrates, and their aberrant activation in humans may lead to cancer. Recent detection of MYB gene rearrangements and mutations in human cancer provides smoking gun evidence of the involvement of MYB family members in human malignancies. Studies linking the activity of MYB family members to human cancers and experimental therapeutic interventions tailored for MYB-expressing cancers are highlighted in this review.

ONCOGENESIS (2021)

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Article Pharmacology & Pharmacy

β-Arrestin1 and GPCR kinase2 play permissive roles in Src-mediated endocytosis of α4β2 nicotinic ACh receptors

Srijan Acharya et al.

Summary: The endocytosis of alpha 4 beta 2 nicotinic ACh receptors occurs through clathrin-mediated endocytosis in a dynamin-dependent manner. Src-mediated phosphorylation of the nAChR alpha 4 subunit at Y575 by 14-3-3 eta is required for endocytosis, with assistance from beta-arrestin1 and GRK2. Endocytosis leads to ubiquitination and down-regulation of alpha 4 beta 2 nAChRs.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Novel, non-invasive markers for detecting therapy induced neuroendocrine differentiation in castration-resistant prostate cancer patients

Divya Bhagirath et al.

Summary: The study identified novel non-invasive exosomal/extracellular vesicle-based biomarkers for diagnosing neuroendocrine differentiation in advanced castration-resistant prostate cancer patients. These biomarkers, including a miRNA panel and TSP1, could potentially guide treatment decisions in a clinically challenging setting.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer

Orlandric Miree et al.

Summary: The study found that aberrant MYB expression in ovarian cancer is positively correlated with tumor grades and stages, and has race-specific prognostic value for African American patients, but not for Caucasian American patients. High levels of MYB transcripts in epithelial ovarian cancer subtypes are associated with poor survival in African American patients, highlighting MYB as a potentially useful clinical biomarker for prognosis in this population.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope

Sirin Saranyutanon et al.

CANCERS (2020)

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Review Oncology

Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research

Sirin Saranyutanon et al.

CANCERS (2020)

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Review Andrology

How do we define castration in men on androgen deprivation therapy?

Sarin Itty et al.

ASIAN JOURNAL OF ANDROLOGY (2020)

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Review Oncology

Interplay between the androgen receptor signaling axis and microRNAs in prostate cancer

Rayzel C. Fernandes et al.

ENDOCRINE-RELATED CANCER (2019)

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Article Medicine, General & Internal

Biomarker Potential of Plasma MicroRNA-150-5p in Prostate Cancer

Ionut Andrei Paunescu et al.

MEDICINA-LITHUANIA (2019)

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Article Cell Biology

MicroRNA-150 suppresses epithelial-mesenchymal transition, invasion, an metastasis in prostate cancer through the TRPM4-mediated β-catenin signaling pathway

Xi Hong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

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Article Oncology

High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma

Michal Tichy et al.

JOURNAL OF CANCER (2019)

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Article Multidisciplinary Sciences

HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

Andrej Gorbatenko et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, Research & Experimental

Molecular determinants of response to high-dose androgen therapy in prostate cancer

Michael D. Nyquist et al.

JCI INSIGHT (2019)

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Article Biochemistry & Molecular Biology

Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12

Jingsong Yu et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2018)

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Article Medicine, Research & Experimental

MicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4

Zhan Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Oncology

Transcription regulation of MYB: a potential and novel therapeutic target in cancer

Partha Mitra

ANNALS OF TRANSLATIONAL MEDICINE (2018)

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Article Medicine, Research & Experimental

Androgen Signaling in Prostate Cancer

Charles Dai et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

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Article Cell Biology

Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein

Shuai Gao et al.

CELL REPORTS (2016)

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Review Oncology

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Philip A. Watson et al.

NATURE REVIEWS CANCER (2015)

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Article Biochemistry & Molecular Biology

Targeting Poly(ADP-Ribose) Polymerase and the c-Myb-Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer

Likun Li et al.

SCIENCE SIGNALING (2014)

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Article Oncology

The role of microRNA in castration-resistant prostate cancer

William Thieu et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2014)

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Article Oncology

The inhibitory role of Mir-29 in growth of breast cancer cells

Zhenglong Wu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2013)

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Article Endocrinology & Metabolism

Androgens Promote Prostate Cancer Cell Growth through Induction of Autophagy

Yan Shi et al.

MOLECULAR ENDOCRINOLOGY (2013)

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Article Oncology

Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance

Sanjeev K. Srivastava et al.

CARCINOGENESIS (2012)

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Article Chemistry, Multidisciplinary

A comparison of androgen deprivation therapy versus surgical castration for patients with advanced prostatic carcinoma

Yu-hsiang Lin et al.

ACTA PHARMACOLOGICA SINICA (2011)

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Article Oncology

MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells

Sanjeev K. Srivastava et al.

CARCINOGENESIS (2011)

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Review Urology & Nephrology

MicroRNA in Prostate, Bladder, and Kidney Cancer: A Systematic Review

James W. F. Catto et al.

EUROPEAN UROLOGY (2011)

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Article Biochemistry & Molecular Biology

Altered VEGF mRNA Stability following Treatments with Immunosuppressive Agents IMPLICATIONS FOR CANCER DEVELOPMENT

Aninda Basu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Endocrinology & Metabolism

The Rules of DNA Recognition by the Androgen Receptor

Sarah Denayer et al.

MOLECULAR ENDOCRINOLOGY (2010)

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Article Hematology

miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53

Francisco Navarro et al.

BLOOD (2009)

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Review Oncology

MYB function in normal and cancer cells

Robert G. Ramsay et al.

NATURE REVIEWS CANCER (2008)

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Article Multidisciplinary Sciences

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells

Xu-Bao Shi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Andrology

Biphasic effect of androgens on prostate cancer cells and its correlation with androgen receptor coactivator dopa decarboxylase

Chen Shao et al.

JOURNAL OF ANDROLOGY (2007)

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Article Biochemistry & Molecular Biology

E2F activity is biphasically regulated by androgens in LNCaP cells

K Hofman et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

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Article Toxicology

Androgens: Biphasic dose responses

EJ Calabrese

CRITICAL REVIEWS IN TOXICOLOGY (2001)

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Biphasic transcriptional and posttranscriptional regulation of MYB by androgen signaling mediates its growth control in prostate cancer

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