4.5 Article

Ergothioneine attenuates varicocele-induced testicular damage by upregulating HSP90AA1 in rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1

Rehab E. Abo El Gheit et al.

Summary: This study aimed to investigate the epigenetic potential of melatonin in varicocele and its molecular mechanisms. The results showed that varicocele caused testicular injury, increased oxidative stress, apoptosis mediated by P53, DNA damage, and upregulated miR-34a expression, while downregulating the SIRT1/FOXO axis. Melatonin treatment improved these changes, including antioxidant/anti-apoptotic effects, reproductive hormone axis, CatSper expression, and fertility parameters.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Andrology

Minocycline can reduce testicular apoptosis related to varicocele in male rats

Majid Shokoohi et al.

Summary: The current study aimed to assess the effects of Minocycline on testicular injury caused by varicocele, focusing on apoptotic-related genes and oxidative stress. The results demonstrated that Minocycline administration improved testicular injury and reduced apoptosis rate, possibly through its antioxidant activity.

ANDROLOGIA (2022)

Article Plant Sciences

Shahatra (F.parviflora Lam)- a comprehensive review of its ethnopharmacology, phytochemistry and pharmacology

F. N. Jamaldeen et al.

Summary: This review discusses the botany, traditional uses, phytochemistry, and pharmacology of F. parviflora. It exhibits a wide range of applications and various pharmacological activities, such as antimicrobial, antioxidant, antidiabetic, hepatoprotective, and anticancer activities. However, there are still gaps in knowledge that require further research, including active ingredients, mechanisms of action, and applications in immunomodulation and hepatic diseases.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Food Science & Technology

Lycopene improves testicular damage and sperm quality in experimentally induced varicocele: Relationship with apoptosis, hypoxia, and hyperthermia

Atefeh Babaei et al.

Summary: Lycopene can improve sperm quality and testicular injury in varicocele patients by reducing apoptosis.

FOOD SCIENCE & NUTRITION (2022)

Article Multidisciplinary Sciences

Olanzapine induced reproductive toxicity in male rats

Cankiz Mina Ardic et al.

Summary: The research revealed that olanzapine had toxic effects on the reproductive system of rats, causing abnormalities in testicular structure, decreased normal sperm morphology, alterations in hormone levels, and oxidative stress in the testis.

SCIENTIFIC REPORTS (2021)

Article Andrology

The association of rs11457523 in HSP90AA1 with idiopathic male infertility in the Chinese population

Yamei Xue et al.

Summary: This study found an association between the rs11547523 SNP in the HSP90AA1 gene and idiopathic male infertility in the Chinese population. However, the specific pathogenic mechanism of this SNP remains unclear, necessitating further research.

ANDROLOGIA (2021)

Review Biochemistry & Molecular Biology

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

Erfaneh Barati et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Article Obstetrics & Gynecology

Losartan ameliorates ovarian ischaemia/reperfusion injury in rats: an experimental study

Ismet Hortu et al.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

Article Biotechnology & Applied Microbiology

Engineering the Yeast Saccharomyces cerevisiae for the Production of L-(+)-Ergothioneine

Steven A. van der Hoek et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Article Biochemistry & Molecular Biology

Effect of Antioxidant Supplementation on the Sperm Proteome of Idiopathic Infertile Men

Ashok Agarwal et al.

ANTIOXIDANTS (2019)

Article Medicine, Research & Experimental

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

Jiali Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biochemistry & Molecular Biology

Ergothioneine - a diet-derived antioxidant with therapeutic potential

Barry Halliwell et al.

FEBS LETTERS (2018)

Article Multidisciplinary Sciences

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

Richard Ming Yi Tang et al.

SCIENTIFIC REPORTS (2018)

Article Oncology

HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Xin Xiao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Reproductive Biology

Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Majid Shokoohi et al.

INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES (2018)

Article Chemistry, Applied

Mushrooms: A rich source of the antioxidants ergothioneine and glutathione

Michael D. Kalaras et al.

FOOD CHEMISTRY (2017)

Review Urology & Nephrology

Varicocele and male infertility

Christian Fuglesang S. Jensen et al.

NATURE REVIEWS UROLOGY (2017)

Review Andrology

The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives

Koji Chiba et al.

ASIAN JOURNAL OF ANDROLOGY (2016)

Review Andrology

Varicocele and testicular function

Alexander W. Pastuszak et al.

ASIAN JOURNAL OF ANDROLOGY (2015)

Review Genetics & Heredity

Regulation and function of the human HSP90AA1 gene

Abbey D. Zuehlke et al.

Article Chemistry, Applied

Prevention of H2O2-induced oxidative stress in Chang liver cells by 4-hydroxybenzyl-chitooligomers

Mai Duy Luu Trinh et al.

CARBOHYDRATE POLYMERS (2014)

Article Oncology

Hsp90 Inhibitors Promote p53-Dependent Apoptosis through PUMA and Bax

Kan He et al.

MOLECULAR CANCER THERAPEUTICS (2013)

Article Food Science & Technology

Ergothioneine protects against neuronal injury induced by β-amyloid in mice

Nae-Cherng Yang et al.

FOOD AND CHEMICAL TOXICOLOGY (2012)

Review Public, Environmental & Occupational Health

The ergothioneine transporter controls and indicates ergothioneine activity - A review

Dirk Gruendemann

PREVENTIVE MEDICINE (2012)

Article Biochemistry & Molecular Biology

The unusual amino acid L-ergothioneine is a physiologic cytoprotectant

B. D. Paul et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Urology & Nephrology

Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats

Jane-Dar Lee et al.

WORLD JOURNAL OF UROLOGY (2009)

Review Biochemistry & Molecular Biology

The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family

H. M. Heath-Engel et al.

ONCOGENE (2008)

Article Agriculture, Multidisciplinary

Dietary sources and antioxidant effects of ergothioneine

Janine Ey et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)

Article Oncology

BCL-2, TP53 and BAX protein expression in superficial urothelial bladder carcinoma

Ricardo Gonzalez-Campora et al.

CANCER LETTERS (2007)

Review Oncology

HSP90 and the chaperoning of cancer

L Whitesell et al.

NATURE REVIEWS CANCER (2005)

Article Biochemistry & Molecular Biology

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

R Zhang et al.

ONCOGENE (2005)

Article Urology & Nephrology

Experimental varicocele induces testicular germ cell apoptosis in the rat

A Barqawi et al.

JOURNAL OF UROLOGY (2004)

Review Biochemistry & Molecular Biology

The Bcl-2 family: roles in cell survival and oncogenesis

S Cory et al.

ONCOGENE (2003)

Article Biochemistry & Molecular Biology

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

T Vanden Berghe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

GQ Chen et al.

MOLECULAR CELL (2002)

Article Obstetrics & Gynecology

The study of varicocele through the use of animal models

TT Turner

HUMAN REPRODUCTION UPDATE (2001)