Microbial and Immune Regulation of the Gut-Lung Axis during Viral-Bacterial Coinfection

Article Gastroenterology & Hepatology

Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study

Giovanni Marasco et al.

Summary: The prevalence of gastrointestinal symptoms in hospitalized patients with COVID-19 is higher than previously reported. Nausea may persist after the resolution of COVID-19 infection.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

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Article Microbiology

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

Robert H. Mills et al.

Summary: Multi-omics analysis of faecal samples from patients with ulcerative colitis suggests a connection between Bacteroides vulgatus protease activity and the severity of disease symptoms. Understanding the disruption of host-microbiota interactions in UC is crucial for developing effective treatments. The study demonstrates that the overabundance of B. vulgatus proteases in a subset of UC patients contributes to disease activity. Targeting the protease activity could be a potential strategy for treating UC.

NATURE MICROBIOLOGY (2022)

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Article Microbiology

Synergism and Antagonism of Bacterial-Viral Coinfection in the Upper Respiratory Tract

Sam Manna et al.

Summary: This study developed a novel mouse model to investigate pneumococcal-viral co-infection in the nasopharynx using PVM and influenza. The findings showed that PVM infection benefits pneumococci by increasing their numbers in the nasopharynx and shedding in respiratory secretions. In contrast, pneumococci decrease PVM numbers by accelerating viral clearance. Similar effect was observed for influenza. The study challenges the existing dogma in the field and has important applications for bacterial and viral vaccines.

MSPHERE (2022)

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Article Infectious Diseases

Bacterial co-infection at hospital admission in patients with COVID-19

Estela Moreno-Garcia et al.

Summary: This study describes the incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. The findings indicate that bacterial co-infections are relatively common, and PCT values and other indicators can be used as references for diagnosis and treatment.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

RSV pneumonia with or without bacterial co-infection among healthy children

Hsiao-Chi Lin et al.

Summary: Respiratory syncytial virus (RSV) is a common cause of childhood pneumonia. Bacterial co-infections can affect the severity of the condition, especially in young children. The study found that children with bacterial co-infection had longer hospital stays, more frequent need for intensive care unit (ICU) care, and higher levels of C-reactive protein.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2022)

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Article Virology

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine

Shanley N. Roach et al.

Summary: Influenza A viruses (IAV) can cause severe disease and death in humans. In this study, it was found that respiratory IAV infection leads to dynamic changes in tuft cells and ILCs in the small intestines. Tuft cells were found to be necessary for the infection-induced increase in small intestine ILC2s. These findings suggest that the intestinal changes in tuft cell and ILC populations may play a role in preventing systemic infection and contribute to severe disease in humans with preexisting conditions.

JOURNAL OF VIROLOGY (2022)

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Article Multidisciplinary Sciences

Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung

Kadi J. Horn et al.

Summary: This study investigates the influence of specific members of the lung microbiome on the early immune response to infection. The researchers found that Prevotella species can enhance protection against Streptococcus pneumoniae, resulting in rapid clearance of the pathogen from the lung and improved survival in a mouse model. This protective response is mediated by Toll-like receptor (TLR)2 recognition of Prevotella melaninogenica lipoproteins, induction of TNF alpha production, and involvement of neutrophils.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Multi-Omics Study of Keystone Species in a Cystic Fibrosis Microbiome

Cynthia B. Silveira et al.

Summary: Anaerobic, mucus-degrading bacteria are key species in CF microbiomes, promoting the growth of pathogens like P. aeruginosa. Targeting these bacteria with clindamycin can suppress their growth and indirectly limit the growth of P. aeruginosa by disrupting fermentation product cross-feeding. This personalized multi-omics approach improved lung function and respiratory health of the patient, supporting its potential for routine clinical diagnostics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Epithelial and Endothelial Expressions of ACE2: SARS-CoV-2 Entry Routes

Ceren Guney et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2021)

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Review Virology

Disease Tolerance during Viral-Bacterial Co-Infections

Tarani Kanta Barman et al.

Summary: This review discusses the role of disease tolerance in viral-bacterial co-infection, focusing on host cytokines and cells that promote tissue protection and damage control.

VIRUSES-BASEL (2021)

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Review Biochemistry & Molecular Biology

Challenges and Perspective in Integrated Multi-Omics in Gut Microbiota Studies

Eric Banan-Mwine Daliri et al.

Summary: The application of multi-omic technologies in gut microbiome studies has unveiled the comprehensive interaction between commensals in health and disease. However, challenges remain in identifying the origin and function of certain proteins and metabolites in gut samples, which may be overcome by combining different omics techniques. Future perspectives in this area include overcoming challenges and advancing our understanding of the gut microbiome through the integration of various omic approaches.

BIOMOLECULES (2021)

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Article Multidisciplinary Sciences

The lower respiratory tract microbiome of critically ill patients with COVID-19

Paolo Gaibani et al.

Summary: COVID-19 critically ill patients have a different lung microbiome compared to non-COVID-19 patients, potentially leading to bacterial superinfection. Infection rates, especially with multidrug resistant pathogens, may increase due to SARS-CoV-2 infection and antibiotic pressure.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection

Shubhanshi Trivedi et al.

Summary: The study found that intestinal infection impacts lung innate immune responses, especially neutrophil characteristics, potentially increasing susceptibility to secondary pneumonia. Mice with prior intestinal infection had higher lung bacterial burden and inflammation when challenged with Klebsiella pneumoniae.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Review Microbiology

The Gut-Lung Axis in Cystic Fibrosis

Courtney E. Price et al.

Summary: Cystic fibrosis is a heritable multiorgan disease that affects tissues expressing the CFTR protein. Recent research has highlighted the crucial role of intestinal microbiota in the gut-lung axis for individuals with CF. Current literature focuses on understanding microbial influences, drivers of microbiota alterations, and the potential for intestinal microbiota remediation in the context of CF.

JOURNAL OF BACTERIOLOGY (2021)

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Article Microbiology

Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome

Carter Merenstein et al.

Summary: The study found that patients with COVID-19 have dysbiosis in the respiratory tract microbiome, with significant changes over time, and the diversity of oropharyngeal microbiome at the initial stage is inversely correlated with disease severity. Additionally, microbiome composition is associated with systemic immune parameters, and machine learning analysis indicates early microbiome features can effectively discriminate COVID-19 severity.

MBIO (2021)

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Article Cell Biology

Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose

Nicholas S. Rhoades et al.

Summary: Research on SARS-CoV-2 infection found a unique nasal microbiome in infected patients, with an increased abundance of bacterial pathogens. Additionally, a strong antiviral innate immune response and neuronal damage were observed in the nasal epithelia of infected patients at the early stage of infection.

CELL REPORTS (2021)

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Article Medicine, General & Internal

Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients

Yingzhi Liu et al.

Summary: This study investigated the clinical features and outcomes of patients with viral-bacterial respiratory tract co-infections in Hong Kong. The results showed that bacterial co-infection is common in hospitalized patients with viral respiratory tract infection and is associated with higher ICU admission rate and mortality. Active surveillance for bacterial co-infection and early antibiotic treatment may be required to improve outcomes in patients with respiratory viral infection.

ECLINICALMEDICINE (2021)

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Review Respiratory System

The role of co-infections and secondary infections in patients with COVID-19

Charles Feldman et al.

Summary: The current review provides an extensive look at the prevalence of co-infections and superinfections in patients with COVID-19, highlighting their potential impact on the severity and outcome of the disease. However, a clear distinction between the two types of infections is often lacking in the literature.

PNEUMONIA (2021)

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Article Immunology

Genomic Diversity of Severe Acute Respiratory Syndrome-Coronavirus 2 in Patients With Coronavirus Disease 2019

Zijie Shen et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Editorial Material Gastroenterology & Hepatology

Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao et al.

GASTROENTEROLOGY (2020)

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Article Medicine, General & Internal

Clinical significance of viral-bacterial codetection among young children with respiratory tract infections Findings of RSV, influenza, adenoviral infections

Jiwon Jung et al.

MEDICINE (2020)

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Article Immunology

Influenza and Bacterial Coinfection in Adults With Community-Acquired Pneumonia Admitted to Conventional Wards: Risk Factors, Clinical Features, and Outcomes

Gabriela Abelenda-Alonso et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

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Article Cell Biology

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Valentin Sencio et al.

CELL REPORTS (2020)

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Review Cell Biology

Interaction between microbiota and immunity in health and disease

Danping Zheng et al.

CELL RESEARCH (2020)

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Review Immunology

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

Raphael Enaud et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Microbiology

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

Dapeng Zhang et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Gastroenterology & Hepatology

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis

Ka Shing Cheung et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection

Lu Lin et al.

GUT (2020)

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Review Immunology

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

Yuhao Jiao et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Infectious Diseases

Co-infections in people with COVID-19: a systematic review and meta-analysis

Louise Lansbury et al.

JOURNAL OF INFECTION (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 productively infects human gut enterocytes

Mart M. Lamers et al.

SCIENCE (2020)

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Review Biochemistry & Molecular Biology

Label or Concept - What is a Pathobiont?

Lara Jochum et al.

TRENDS IN MICROBIOLOGY (2020)

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Article Multidisciplinary Sciences

Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

Drishti Kau et al.

NATURE COMMUNICATIONS (2020)

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Article Pediatrics

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood

Jaelle C. Brealey et al.

PEDIATRIC PULMONOLOGY (2020)

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Review Microbiology

Pneumolysin: Pathogenesis and Therapeutic Target

Andrew T. Nishimoto et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Infectious Diseases

Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection

Hui Zhang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

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Review Microbiology

Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases

Juan Alberto Lira-Lucio et al.

MICROORGANISMS (2020)

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Letter Biochemistry & Molecular Biology

Pseudomonas aeruginosa Can Degrade Interferon lambda, Thereby Repressing the Antiviral Response of Bronchial Epithelial Cells

Adeline Peignier et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2020)

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Article Multidisciplinary Sciences

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Jack Major et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Achille Broggi et al.

SCIENCE (2020)

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Article Immunology

Influenza Infection Induces Alveolar Macrophage Dysfunction and Thereby Enables Noninvasive Streptococcus pneumoniae to Cause Deadly Pneumonia

Atul K. Verma et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

Maximillian S. Habibi et al.

SCIENCE (2020)

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Article Biochemistry & Molecular Biology

IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19

Yu Chen et al.

MOLECULAR MEDICINE (2020)

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Article Immunology

Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection

Helen E. Rich et al.

INFECTION AND IMMUNITY (2019)

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Article Immunology

Monocytes Represent One Source of Bacterial Shielding from Antibiotics following Influenza Virus Infection

Karl J. Fischer et al.

JOURNAL OF IMMUNOLOGY (2019)

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Article Virology

Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus

Michaela E. Nickol et al.

VIRUSES-BASEL (2019)

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Article Multidisciplinary Sciences

Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections

Jocelyn R. Grunwell et al.

SCIENTIFIC REPORTS (2019)

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Article Microbiology

Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information

Ana Georgina Cobian Guemes et al.

MBIO (2019)

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Article Microbiology

Direct interactions with influenza promote bacterial adherence during respiratory infections

Hannah M. Rowe et al.

NATURE MICROBIOLOGY (2019)

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Article Multidisciplinary Sciences

Airway response to respiratory syncytial virus has incidental antibacterial effects

Charles J. Sande et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach

Maria Guirro et al.

PLOS ONE (2019)

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Review Pediatrics

Lower Airway Microbiota

Giulio Pulvirenti et al.

FRONTIERS IN PEDIATRICS (2019)

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Article Critical Care Medicine

Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

Lydia J. Finney et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Loss of T-bet confers survival advantage to influenza-bacterial superinfection

Jun Zhi Er et al.

EMBO JOURNAL (2019)

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Article Food Science & Technology

Staphylococcus aureus Pneumonia: Preceding Influenza Infection Paves the Way for Low-Virulent Strains

Stefanie Deinhardt-Emmer et al.

TOXINS (2019)

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Review Pediatrics

The lung microbiome in neonates

Dhivya Lakshmi Permall et al.

TURKISH JOURNAL OF PEDIATRICS (2019)

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Article Microbiology

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

Andrea K. Erickson et al.

CELL HOST & MICROBE (2018)

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Article Biochemistry & Molecular Biology

Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death

Andre van Kruechten et al.

FASEB JOURNAL (2018)

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Article Immunology

Secondary Bacterial Pneumonia by Staphylococcus aureus Following Influenza A Infection Is SaeR/S Dependent

Timothy R. Borgogna et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Article Immunology

Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota

Helen T. Groves et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Microbiology

Influenza A virus infection impacts systemic microbiota dynamics and causes quantitative enteric dysbiosis

Soner Yildiz et al.

MICROBIOME (2018)

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Review Physiology

Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma

Elliot Mathieu et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Immunology

STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection

Radha Gopal et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Microbiology

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

Celine Pattaroni et al.

CELL HOST & MICROBE (2018)

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Review Immunology

Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia

Shigeo Hanada et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Respiratory System

The microbiome in respiratory medicine: current challenges and future perspectives

Rosa Faner et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

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Review Biology

Role of microbiota on lung homeostasis and diseases

Jian Wang et al.

SCIENCE CHINA-LIFE SCIENCES (2017)

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Review Virology

Virus-Bacteria Interactions: An Emerging Topic in Human Infection

Erin A. Almand et al.

VIRUSES-BASEL (2017)

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Article Immunology

Impact of Age, Caloric Restriction, and Influenza Infection on Mouse Gut Microbiome: An Exploratory Study of the Role of Age-Related Microbiome Changes on Influenza Responses

Jenna M. Bartley et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Review Immunology

Protective Microbiota: From Localized to Long-Reaching Co-immunity

Lynn Chiu et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Infectious Diseases

Clinical and virological factors associated with gastrointestinal symptoms in patients with acute respiratory infection: a two-year prospective study in general practice medicine

Laetitia Minodier et al.

BMC INFECTIOUS DISEASES (2017)

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Review Physiology

The Microbiome and the Respiratory Tract

Robert P. Dickson et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 78 (2016)

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Review Multidisciplinary Sciences

The microbiota in adaptive immune homeostasis and disease

Kenya Honda et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity

Matthew R. Hendricks et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Virology

Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung

Hiroki Ishikawa et al.

VIROLOGY (2016)

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Article Microbiology

Staphylococcus aureus and Influenza A Virus: Partners in Coinfection

Michelle E. Mulcahy et al.

MBIO (2016)

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Article Microbiology

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

Elisa Deriu et al.

PLOS PATHOGENS (2016)

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Article Microbiology

Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract

Jeffrey A. Melvin et al.

PLOS PATHOGENS (2016)

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Article Microbiology

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

Leopoldo N. Segal et al.

NATURE MICROBIOLOGY (2016)

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Article Multidisciplinary Sciences

Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study

Jonathan Hoffmann et al.

Scientific Reports (2016)

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Article Biotechnology & Applied Microbiology

Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features

Guoqin Yu et al.

GENOME BIOLOGY (2016)

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Article Physiology

Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice

Benjamin Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

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Article Public, Environmental & Occupational Health

Concurrent Pneumonia in Children under 5 Years of Age Presenting to a Diarrheal Hospital in Dhaka, Bangladesh

Daniel T. Leung et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2015)

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Article Biochemistry & Molecular Biology

TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

Gregory T. Ellis et al.

EMBO REPORTS (2015)

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Article Biochemistry & Molecular Biology

Early life dynamics of the human gut virome and bacterial microbiome in infants

Efrem S. Lim et al.

NATURE MEDICINE (2015)

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Review Virology

Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: what do we know?

Laetitia Minodier et al.

VIROLOGY JOURNAL (2015)

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Article Microbiology

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

Christine M. Bassis et al.

MBIO (2015)

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Article Biology

Viral dark matter and virus-host interactions resolved from publicly available microbial genomes

Simon Roux et al.

ELIFE (2015)

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Article Cell Biology

Super-infection with Staphylococcus aureus inhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization

Kathrin Warnking et al.

CELLULAR MICROBIOLOGY (2015)

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Article Multidisciplinary Sciences

Influenza viral neuraminidase primes bacterial coinfection through TGF-β-mediated expression of host cell receptors

Ning Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Respiratory System

Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography

Robert P. Dickson et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2015)

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Article Critical Care Medicine

Respiratory Syncytial Virus Increases the Virulence of Streptococcus pneumoniae by Binding to Penicillin Binding Protein 1a A New Paradigm in Respiratory Infection

Claire M. Smith et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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Article Infectious Diseases

Acute diarrhea in adults consulting a general practitioner in France during winter: incidence, clinical characteristics, management and risk factors

Christophe Arena et al.

BMC INFECTIOUS DISEASES (2014)

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Review Biochemistry & Molecular Biology

Role of the Microbiota in Immunity and Inflammation

Yasmine Belkaid et al.

CELL (2014)

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Article Microbiology

Bacterial Lipopolysaccharide Binding Enhances Virion Stability and Promotes Environmental Fitness of an Enteric Virus

Christopher M. Robinson et al.

CELL HOST & MICROBE (2014)

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Article Immunology

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation

Jian Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

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Article Immunology

Influenza Infection Suppresses NADPH Oxidase-Dependent Phagocytic Bacterial Clearance and Enhances Susceptibility to Secondary Methicillin-Resistant Staphylococcus aureus Infection

Keer Sun et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Immunology

Influenza A Virus Exacerbates Staphylococcus aureus Pneumonia in Mice by Attenuating Antimicrobial Peptide Production

Keven M. Robinson et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

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Review Biochemistry & Molecular Biology

Anti-infective properties of bacteriocins: an update

Riadh Hammami et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

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Article Immunology

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections

Hazem E. Ghoneim et al.

JOURNAL OF IMMUNOLOGY (2013)

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Review Immunology

Immune Dysfunction and Bacterial Coinfections following Influenza

Dennis W. Metzger et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Medicine, General & Internal

Childhood Pneumonia and Diarrhoea 1 Global burden of childhood pneumonia and diarrhoea

Christa L. Fischer Walker et al.

LANCET (2013)

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Review Microbiology

The gut microbiota - masters of host development and physiology

Felix Sommer et al.

NATURE REVIEWS MICROBIOLOGY (2013)

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Article Virology

Bats and their virome: an important source of emerging viruses capable of infecting humans

Ina Smith et al.

CURRENT OPINION IN VIROLOGY (2013)

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Article Public, Environmental & Occupational Health

Diarrhea as a risk factor for acute lower respiratory tract infections among young children in low income settings

Christa L. Fischer Walker et al.

JOURNAL OF GLOBAL HEALTH (2013)

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Article Biochemistry & Molecular Biology

Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome

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