Sustainability of peritoneal dialysis and renal function with proactive combination therapy

Article Hematology

Ultrafiltration volume by once-weekly hemodialysis is a predictor of technique survival of combination therapy with peritoneal dialysis and hemodialysis

Mototsugu Tanaka et al.

Summary: The study shows that chronic overhydration is the main cause of technique failure in peritoneal dialysis patients. Patients in the high-UF group had lower extracellular water content normalized to height compared to the low-UF group.

THERAPEUTIC APHERESIS AND DIALYSIS (2021)

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Article Engineering, Biomedical

Preserved peritoneal function by short-term two-day peritoneal rest in hemodialysis combination therapy patients

Atsushi Ueda et al.

Summary: This study demonstrates that the peritoneal permeability decreases significantly after a two-day peritoneal rest in PD patients, but the PD ultrafiltration volume repeatedly improves. Short-term peritoneal rest may help preserve peritoneal function.

JOURNAL OF ARTIFICIAL ORGANS (2021)

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Review Biochemistry & Molecular Biology

Indoxyl-Sulfate-Induced Redox Imbalance in Chronic Kidney Disease

Chien-Lin Lu et al.

Summary: The uremic toxin IS leads to oxidative stress in CKD patients, causing organ damage and complications such as cardiovascular diseases, renal osteodystrophy, muscle wasting, and anemia. IS-induced ROS production impairs glomerular filtration and triggers vascular smooth muscle cells transformation, contributing to muscle atrophy and bone abnormalities.

ANTIOXIDANTS (2021)

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Article Urology & Nephrology

Combination of once-weekly haemodialysis with peritoneal dialysis is associated with lower mortality compared with peritoneal dialysis alone: a longitudinal study

Miho Murashima et al.

Summary: This study compared the outcomes of combined peritoneal dialysis with weekly hemodialysis and peritoneal dialysis alone in Japan. It found that the combination therapy was associated with lower all-cause mortality, cardiovascular mortality, and congestive heart failure-related mortality, but the transition to hemodialysis was earlier.

CLINICAL KIDNEY JOURNAL (2021)

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Article Urology & Nephrology

Peritoneal Dialysis Guidelines 2019 Part 1 (Position paper of Japanese Society of Dialysis Therapy)

Yasuhiko Ito et al.

Summary: In the past decade, new evidence related to peritoneal dialysis has emerged, necessitating the incorporation of these developments into new clinical practice guidelines. The process of creating guidelines has significantly changed globally, with this article utilizing global standard methods for systematic reviews.

RENAL REPLACEMENT THERAPY (2021)

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Article Hematology