The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals

Article Neurosciences

Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling

Jamie M. Walker et al.

Summary: Resilient individuals exhibit protein expression patterns suggestive of an environment with less energetic and oxidative stress, resulting in the maintenance of neuronal and synaptic integrity.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

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Review Clinical Neurology

Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes

Teresa Gomez-Isla et al.

Summary: Some individuals can accumulate high levels of Alzheimer's disease neuropathological changes without showing symptoms, which has implications for risk prediction and the development of therapeutic interventions.

NATURE REVIEWS NEUROLOGY (2022)

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Article Clinical Neurology

Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts

Peter T. Nelson et al.

Summary: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer's disease neuropathologic change (ADNC) are both associated with cognitive impairment in aging populations, with LATE-NC being present in approximately 40% of participants and more commonly in cases with poorer cognitive abilities.

ACTA NEUROPATHOLOGICA (2022)

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Article Neurosciences

Risk of Dementia in Cancer Survivors: A Meta-Analysis of Population-Based Cohort Studies

Dan-Dan Zhang et al.

Summary: The risk of dementia among cancer survivors is decreased, especially in survivors of colon, leukemia, small intestine, and thyroid cancers. However, prostate cancer patients treated with androgen deprivation therapy have a significantly increased risk of dementia and Alzheimer's disease.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Review Neurosciences

Amyloid ?, Tau, and ?-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases

Urmi Sengupta et al.

Summary: This review summarizes the histopathological features of specific protein aggregation in several neurodegenerative diseases and discusses their overlap. It also highlights the synergistic interplay among Aβ, tau, and alpha-Syn in these diseases, suggesting a protein triumvirate.

PROGRESS IN NEUROBIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Cancer and Alzheimer's disease inverse relationship: an age-associated diverging derailment of shared pathways

Cristina Lanni et al.

Summary: Several epidemiological studies have shown a negative correlation between cancer and Alzheimer's disease. The review focuses on analyzing common biological mechanisms for both diseases, particularly highlighting the roles of PIN1 and p53 in understanding this inverse correlation. These molecular players may provide insight into potential therapeutic targets for both cancer and AD.

MOLECULAR PSYCHIATRY (2021)

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Article Clinical Neurology

The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans

Mohamad Habes et al.

Summary: The relationship between white matter hyperintensities and various factors such as brain aging, AD neuropathology, cognitive decline, and Aβ positivity after age 65 have been observed in a large MRI database. The Brain Chart established can quantify brain-aging trajectories and provide systematic evaluation of brain-aging patterns relative to a large consortium. Brain aging, AD-like atrophy, and WMHs were shown to be better predictors of cognition than chronological age in MCI/AD subjects.

ALZHEIMERS & DEMENTIA (2021)

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Article Clinical Neurology

Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy

Jamie M. Walker et al.

Summary: Primary age-related tauopathy (PART) is a neurodegenerative condition that primarily affects the medial temporal lobe, showing similarities to Alzheimer's disease (AD) but also distinct characteristics such as early vulnerability of the CA2 subregion. The distribution of tau pathology in PART differs from AD, highlighting the need for a better understanding of how PART contributes to cognitive impairment.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2021)

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Article Clinical Neurology

Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia

Kirsty E. McAleese et al.

Summary: The aged brain often exhibits multiple pathologies, rather than a single pathology, and the presence of multiple pathologies can significantly worsen cognitive decline, increasing the risk of transitioning from mild cognitive impairment to dementia.

ALZHEIMERS & DEMENTIA (2021)

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Article Neurosciences

Paucity of Entorhinal Cortex Pathology of the Alzheimer's Type in SuperAgers with Superior Memory Performance

Tamar Gefen et al.

Summary: The study revealed that Cognitive SuperAgers have significantly fewer NFTs in the entorhinal cortex compared to age-matched cognitively average normal controls, suggesting their resistance to age-related neurofibrillary degeneration could contribute to preserved memory.

CEREBRAL CORTEX (2021)

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Article Neurosciences

Inverse Correlation Between Alzheimer's Disease and Cancer: Short Overview

Agnieszka Zablocka et al.

Summary: The negative association between Alzheimer's disease and cancer suggests that susceptibility to one disease may protect against the other. Understanding the biological mechanisms of AD and cancer, as well as their relationship, could lead to overcoming the unsolved problems of both diseases affecting the growing human population.

MOLECULAR NEUROBIOLOGY (2021)

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Editorial Material Clinical Neurology

Improving the resistance and resilience framework for aging and dementia studies

Eider M. Arenaza-Urquijo et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

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Article Clinical Neurology

MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide

Vishnu M. Bashyam et al.

BRAIN (2020)

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Review Biochemistry & Molecular Biology

Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core

Elena Vacchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Neurosciences

Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases

Emily Rogalski et al.

HIPPOCAMPUS (2019)

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Article Neurosciences

Cognitive Resilience to Alzheimer's Disease Pathology in the Human Brain

Erin J. Aiello Bowles et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Editorial Material Clinical Neurology

Concepts for brain aging: resistance, resilience, reserve, and compensation

Thomas J. Montine et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

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Review Clinical Neurology

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

Peter T. Nelson et al.

BRAIN (2019)

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Article Neurosciences

Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

Caitlin S. Latimer et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

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Article Neurosciences

Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex

Margaret E. Flanagan et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Clinical Neurology

Resistance vs resilience to Alzheimer disease Clarifying terminology for preclinical studies

Eider M. Arenaza-Urquijo et al.

NEUROLOGY (2018)

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Article Clinical Neurology

Does taking statins affect the pathological burden in autopsy-confirmed Alzheimer's dementia?

Jana Crum et al.

ALZHEIMERS RESEARCH & THERAPY (2018)

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Article Neurosciences

Glioma and Alzheimer's Disease

Steven Lehrer

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2018)

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Article Clinical Neurology

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

David Irwin et al.

LANCET NEUROLOGY (2017)

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Article Multidisciplinary Sciences

A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer

Jon Sanchez-Valle et al.

SCIENTIFIC REPORTS (2017)

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Article Clinical Neurology

Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies

Lon R. White et al.

NEUROLOGY (2016)

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Article Psychiatry

Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns

M. Habes et al.

TRANSLATIONAL PSYCHIATRY (2016)

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Article Genetics & Heredity

Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses

Kristina Ibanez et al.

PLOS GENETICS (2014)

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Article Clinical Neurology

Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology

Beatriz G. Perez-Nievas et al.

BRAIN (2013)

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Article Clinical Neurology

Inverse occurrence of cancer and Alzheimer disease A population-based incidence study

Massimo Musicco et al.

NEUROLOGY (2013)

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Article Multidisciplinary Sciences

Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform

Timothy Liu et al.

SCIENTIFIC REPORTS (2013)

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Article Clinical Neurology

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

Thomas J. Montine et al.

ACTA NEUROPATHOLOGICA (2012)

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Article Clinical Neurology

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Bradley T. Hyman et al.

ALZHEIMERS & DEMENTIA (2012)

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Review Clinical Neurology

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)

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Article Medicine, Research & Experimental

Epidemiology of Alzheimer Disease

Richard Mayeux et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

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Article Medicine, General & Internal

Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

Jane A. Driver et al.

BRITISH MEDICAL JOURNAL (2012)

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Article Clinical Neurology

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

John C. Breitner et al.

ALZHEIMERS & DEMENTIA (2011)

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A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

M. Sano et al.

NEUROLOGY (2011)

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Review Clinical Neurology

Classification and basic pathology of Alzheimer disease

Charles Duyckaerts et al.

ACTA NEUROPATHOLOGICA (2009)

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Article Clinical Neurology

Association of higher diastolic blood pressure levels with cognitive impairment

G. Tsivgoulis et al.

NEUROLOGY (2009)

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Article Clinical Neurology

The oldest old and the 90+ Study

Claudia H. Kawas

ALZHEIMERS & DEMENTIA (2008)

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Review Clinical Neurology

The National Alzheimer's Coordinating Center (NACC) database: The uniform data set

Duane L. Beekly et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2007)

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Article Clinical Neurology

Dementia and Alzheimer disease incidence - A prospective cohort study

WA Kukull et al.

ARCHIVES OF NEUROLOGY (2002)

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Phases of Aβ-deposition in the human brain and its relevance for the development of AD

DR Thal et al.

NEUROLOGY (2002)

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Article Psychiatry

Distinguishing between neurodegenerative disease and disease-free aging: Correlating neuropsychological evaluations and neuropathological studies in centenarians

MH Silver et al.

PSYCHOSOMATIC MEDICINE (2002)

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The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals

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