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Protein Kinases as Potential Targets Contribute to the Development of Agrochemicals

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AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c06222

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protein kinases; targetability; antifungals; stress tolerance; plant immunity; agrochemicals discovery

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Using agrochemicals targeting protein kinases to combat pest insects, fungi, and weeds is gaining increasing attention and has potential prospects in agrochemical development. However, there is a lack of comprehensive summary and discussion on the targetability of protein kinases in this field. This study provides guidance and a quick understanding of the role of protein kinases, benefiting both agrochemical development and non-professionals' learning.
Using agrochemicals against pest insects, fungi, and weeds plays a major part in maintaining and improving crop yields, which helps to solve the issue of food security. Due to the limited targets and resistance of agrochemicals, protein kinases are regarded as attractive potential targets to develop new agrochemicals. Recently, a lot of investigations have shown the extension of agrochemicals by targeting protein kinases, implying an increasing concern for this kind of method. However, few people have summarized and discussed the targetability of protein kinases contributing to the development of agrochemicals. In this work, we introduce the research on protein kinases as potential targets used in crop protection and discuss the prospects of protein kinases in the field of agrochemical development. This study may not only provide guidance for the contribution of protein kinases to the development of agrochemicals but also help nonprofessionals such as students learn and understand the role of protein kinases quickly.

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