期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 51, 页码 16164-16175出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c05464
关键词
Eurotium cristatum; colitis; tryptophan metabolism; gut microbiota
资金
- National Natural Science Foundation of China [31871752, 31901647, 32072175]
- Key Research and Development Plan in Shaanxi province [2021NY-184, 2020ZDLSF01-07, 2022QFY09-06]
- Fundamental Research Funds for the Central Universities of Shaanxi Normal University [GK202103100, TD2020043Y]
- Development Program for Innovative Research Team of Shaanxi Normal University [GK202101006]
- China Postdoctoral Science Foundation [2019M650255]
- Key Laboratory of Se-enriched Products Development and Quality Control, Ministry of Agriculture and Rural Affairs/National-Local Joint Engineering Laboratory of Se-enriched Food Development
- Xi'an Agricultural Technology Research and Development Project [21NYYF0054, 22NYYF046]
Research suggests that Eurotium cristatum from Fu-brick tea can enhance intestinal barrier function by regulating microbiota and enhancing tryptophan metabolism, thereby inhibiting colon damage and other effects of colitis.
Fu-brick tea (FBT) has attracted the attention of researchers because of its unique nutritional value, but it remains unknown whether Eurotium cristatum, the critical fungus from FBT, is responsible for the observed anti-colitis effects of FBT. Herein, the effects of E. cristatum on dextran sulfate sodium (DSS)-induced ulcerative colitis was first discussed. The results illustrated that the oral administration of E. cristatum inhibited DSS-induced colon damage. Microbiota analysis revealed that E. cristatum improved the intestinal homeostasis of colitis mice, especially increased the proportion of Lactobacillus, followed by an obvious increase in fecal short-chain fatty acids (SCFAs). Besides, E. cristatum markedly promoted tryptophan metabolism and increased the fecal contents of tryptophan metabolites in colitis mice. Furthermore, E. cristatum drastically increased the content of colonic IL-22 and the expression of tight-junction proteins. Conclusively, these results suggest that E. cristatum can resist colon damage and other implications of colitis by regulating the microbiota and enhancing tryptophan metabolism to strengthen intestinal barriers.
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